scholarly journals An analysis of Electrophilic Aromatic Substitution: A “complex approach”

2020 ◽  
Author(s):  
Nikola Stamenković ◽  
N. P. Ulrih ◽  
Janez Cerkovnik
Keyword(s):  
Organic Chemistry ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Synthetic Organic Chemistry ◽  
Complex Approach

Electrophilic aromatic substitution (EAS) is one of the most widely researched transforms in synthetic organic chemistry. Numerous studies have been carried out to provide an understanding of the nature of...

Synthesis of new 5-bromo derivatives of indole and spiroindole phytoalexins

2015 ◽  
Vol 0 (0) ◽  
Author(s):  
Lucia Očenášová ◽  
Peter Kutschy ◽  
Jozef Gonda ◽  
Martina Pilátová ◽  
Gabriela Gönciová ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Cell Lines ◽  
Electrophilic Substitution ◽  
Electrophilic Aromatic Substitution ◽  
Aromatic Substitution ◽  
Human Tumour ◽  
Leukaemia Cell ◽  
Tumour Cell Lines ◽  
Derivatives Of ◽  
Human Tumour Cell Lines

AbstractElectrophilic aromatic substitution is one of the most thoroughly studied reactions in organic chemistry. In the present paper, the 5-brominated spirobrassinol methyl ethers VII, VIII were obtained by electrophilic substitution of the aromatic core of indoline at the C-5 position in the presence of various brominating agents. The same products were also prepared from 5-bromoindole (IX ) following the sequence for the synthesis 1-methoxyspirobrassinol methyl ether (V) from indoline. In addition, the new related 5-bromospiroindoline derivatives XX-XXIII were synthesised and their biological activity on human tumour cell lines was examined. The presence of bromine in the indole or indoline skeleton at the C-5 position resulted in the partial increase in anticancer activity on leukaemia cell lines (Jurkat, CEM). The structures of the newly prepared products were determined by

Recent Developments in the Asymmetric Detrifluoroacetylative Reactions of in situ Generated Mono-Fluorinated Enolates

2020 ◽  
Vol 24 (18) ◽  
pp. 2181-2191
Author(s):  
Li Wang ◽  
Ziyi Li ◽  
Jiang Liu ◽  
Jianlin Han ◽  
Hiroki Moriwaki ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Bond Cleavage ◽  
Synthetic Methodology ◽  
Research Topics ◽  
Synthetic Organic Chemistry ◽  
Nucleophilic Reactions ◽  
F Center ◽  
Recent Developments

The development of an efficient and mild synthetic methodology for the construction of bioactive fluorine-containing molecules represents one of the hot research topics in general synthetic organic chemistry. In this review, some recent progresses achieved in the development of detrifluoroacetylatively generated mono-fluorinated enolates via CC bond cleavage and their asymmetric nucleophilic reactions for assembly of chiral quaternary C-F center containing compounds.

An approach to computer-assisted drill in synthetic organic chemistry

1973 ◽  
Vol 50 (9) ◽  
pp. 645
Author(s):  
H. A. Clark ◽  
J. C. Marshall ◽  
T. L. Isenhour
Keyword(s):  
Organic Chemistry ◽  
Computer Assisted ◽  
Synthetic Organic Chemistry

Recent advances and perspectives in manganese-catalyzed C–H activation

2021 ◽  
Author(s):  
Thaipparambil Aneeja ◽  
Mohan Neetha ◽  
C. M. A. Afsina ◽  
Gopinathan Anilkumar
Keyword(s):  
Organic Chemistry ◽  
Synthetic Organic Chemistry ◽  
Recent Advances

Manganese-catalyzed C–H activation has become an emerging area in organic chemistry. These efficient and eco-friendly manganese catalysed reactions provides new opportunities in the field of synthetic organic chemistry.

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