How Parkinson's disease-related mutations disrupt the dimerization of WD40 domain in LRRK2: a comparative molecular dynamics simulation study

2020 ◽  
Vol 22 (36) ◽  
pp. 20421-20433
Author(s):  
Xinyi Li ◽  
Mingyu Ye ◽  
Yue Wang ◽  
Ming Qiu ◽  
Tingting Fu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Molecular Dynamics ◽  
Parkinson's Disease ◽  
Molecular Dynamics Simulation ◽  
Neurodegenerative Disease ◽  
Simulation Study ◽  
Dynamics Simulation ◽  
Pathogenic Factor ◽  
Leucine Rich Repeat ◽  
Wd40 Domain

The multidomain kinase enzyme leucine-rich-repeat kinase 2 (LRRK2), activated through a homodimerization manner, is identified as an important pathogenic factor in Parkinson's disease (PD), the second most common neurodegenerative disease wordwide.

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