Thermodynamics of cell penetrating peptides on lipid membranes: sequence and membrane acidity regulate surface binding

2020 ◽  
Vol 22 (40) ◽  
pp. 23399-23410
Author(s):  
Pedro G. Ramírez ◽  
Mario G. Del Pópolo ◽  
Jorge A. Vila ◽  
Gabriel S. Longo
Keyword(s):  
Lipid Membranes ◽  
Cell Penetrating Peptides ◽  
Surface Binding ◽  
Cell Penetrating ◽  
Acidic Lipids

Acidic lipids respond to pH in ways that fully promote or deplete the surface accumulation of cell penetrating peptides.

scholarly journals Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Andreas Weinberger ◽  
Vivien Walter ◽  
Sarah R. MacEwan ◽  
Tatiana Schmatko ◽  
Pierre Muller ◽  
...  
Keyword(s):  
Self Assembly ◽  
Lipid Membranes ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating

scholarly journals The single GUV method for revealing the functions of antimicrobial, pore-forming toxin, and cell-penetrating peptides or proteins

2014 ◽  
Vol 16 (30) ◽  
pp. 15752-15767 ◽  
Author(s):  
Md. Zahidul Islam ◽  
Jahangir Md. Alam ◽  
Yukihiro Tamba ◽  
Mohammad Abu Sayem Karal ◽  
Masahito Yamazaki
Keyword(s):  
Rate Constants ◽  
Lipid Membranes ◽  
Pore Formation ◽  
Cell Penetrating Peptides ◽  
Elementary Processes ◽  
Cell Penetrating

The single GUV method provides detailed information on the elementary processes of peptide/protein-induced pore formation in lipid membranes and the entry of peptides into a GUV; specifically, the GUV method provides the rate constants of these processes.

Label-free quantification of cell-penetrating peptide translocation into liposomes

2016 ◽  
Vol 8 (23) ◽  
pp. 4608-4616 ◽  
Author(s):  
Marie-Lise Jobin ◽  
Isabel D. Alves
Keyword(s):  
Small Molecules ◽  
Lipid Membranes ◽  
Cell Penetrating Peptides ◽  
Cell Penetrating Peptide ◽  
Label Free ◽  
Label Free Quantification ◽  
Cell Penetrating ◽  
Free Quantification ◽  
Peptide Translocation

Cell penetrating peptides (CPPs) are small molecules capable of crossing lipid membranes and transporting cargos of varied sizes and nature inside cells.

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