scholarly journals The role of energy cost on accuracy, sensitivity, specificity, speed and adaptation of T cell foreign and self recognition

2021 ◽  
Vol 23 (4) ◽  
pp. 2860-2872
Author(s):  
Gyubaek Shin ◽  
Jin Wang
Keyword(s):  
T Cell ◽  
Kinetic Model ◽  
Energy Cost ◽  
Self Recognition ◽  
Sensitivity Specificity ◽  
Physical Outcomes

Various physical outcomes are obtained based on a kinetic model illustrating recognitions of T cell.

scholarly journals Correction: The role of energy cost on accuracy, sensitivity, specificity, speed and adaptation of T cell foreign and self recognition

2021 ◽  
Author(s):  
Gyubaek Shin ◽  
Jin Wang
Keyword(s):  
T Cell ◽  
Energy Cost ◽  
Chem Phys ◽  
Self Recognition ◽  
Sensitivity Specificity ◽  
Phys Chem Chem Phys

Correction for ‘The role of energy cost on accuracy, sensitivity, specificity, speed and adaptation of T cell foreign and self recognition’ by Gyubaek Shin et al., Phys. Chem. Chem. Phys., 2021, 23, 2860–2872, DOI: 10.1039/D0CP02422H.

Self-recognition is crucial for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment

Blood ◽  
2006 ◽  
Vol 108 (1) ◽  
pp. 270-277 ◽  
Author(s):  
Bruno Martin ◽  
Chantal Bécourt ◽  
Boris Bienvenu ◽  
Bruno Lucas
Keyword(s):  
T Cells ◽  
T Cell ◽  
Mhc Class Ii ◽  
Cd4 T Cells ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Cell Pool ◽  
Self Recognition ◽  
Mhc Class Ii Molecules

The role of self-recognition in the maintenance of the peripheral CD4+ T-cell pool has been extensively studied, but no clear answer has so far emerged. Indeed, in studies of the role of self-major histocompatibility complex (MHC) molecules in CD4+ T-cell survival, several parameters must be taken into account when interpreting the results: (1) in a lymphopenic environment, observations are biased by concomitant proliferation of T cells arising in MHC-expressing mice; (2) the peripheral T-cell compartment is qualitatively and quantitatively different in nonlymphopenic, normal, and MHC class II-deficient mice; and (3) in C57BL/6 Aβ-/- mice (traditionally considered MHC class II-deficient), the Aα chain and the Eβ chain associate to form a hybrid AαEβ MHC class II molecule. In light of these considerations, we revisited the role of interactions with MHC class II molecules in the survival of peripheral CD4+ T cells. We found that the answer to the question “is self-recognition required for CD4+ T cells to survive?” is not a simple yes or no. Indeed, although long-term survival of CD4+ T cells does not depend on self-recognition in lymphopenic mice, interactions with MHC class II molecules are required for maintaining the peripheral CD4+ T-cell pool in a nonlymphopenic environment. (Blood. 2006;108:270-277)

On the role of self-recognition in T cell responses to foreign antigen

2003 ◽  
Vol 191 (1) ◽  
pp. 97-106 ◽  
Author(s):  
Irena Stefanova ◽  
Jeffrey R. Dorfman ◽  
Makoto Tsukamoto ◽  
Ronald N. Germain
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Foreign Antigen ◽  
Cell Responses ◽  
Self Recognition

Role of CD5 expression on TCRγδ T cell-differentiation and development of chronic intestinal inflammation

2001 ◽  
Vol 120 (5) ◽  
pp. A517-A517
Author(s):  
A MIZOGUCHI ◽  
E MIZOGUCHI ◽  
Y DEJONG ◽  
H TAKEDATSU ◽  
F PREFFER ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
T Cell ◽  
Intestinal Inflammation ◽  
T Cell Differentiation ◽  
Chronic Intestinal Inflammation
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