Non-specific DNA-driven quinary interactions promote structural transitions in proteins

2020 ◽  
Vol 22 (22) ◽  
pp. 12671-12677 ◽  
Author(s):  
Soundhararajan Gopi ◽  
Athi N. Naganathan

We show strong evidence for the long-range electrostatic potential of DNA to influence the conformational status and distribution of states accessible to a protein chain well before the binding event.

2011 ◽  
Vol 222 ◽  
pp. 239-242 ◽  
Author(s):  
Zilgma Irbe ◽  
Linda Vecbiskena ◽  
Liga Berzina-Cimdina

In this work properties of potential brushite (CaHPO4•2H2O) and hydroxyapatite (Ca10(PO4)6(OH)2) compound cements are investigated. Calcium dihydrogenphosphate monohydrate (MCPM) and α-tricalcium phosphate (α-TCP) were the starting materials for investigated cements. Setting time is controlled by adding setting time retarder – citrate ions and initially unreactive filler - monetite (CaHPO4). Some compositions of obtained cements contain both brushite and hydroxyapatite. However a substantial amount of monetite was present even if it is not added as filler. There is a strong evidence of presence of octacalcium phosphate – a precursor phase for hydroxyapatite that lacks long range order.


1999 ◽  
Vol 4 (S1) ◽  
pp. 203-208 ◽  
Author(s):  
C. Ronning ◽  
K.J. Linthicum ◽  
E.P Carlson ◽  
P.J. Hartlieb ◽  
D.B. Thomson ◽  
...  

Single crystalline (0001) gallium nitride layers were implanted with beryllium and subsequently annealed within the range of 300-1100 °C for 10-60 minutes under a flux of atomic nitrogen obtained using a rf plasma source. The nitrogen flux protected the GaN surface from decomposition in vacuum at high temperatures. SIMS measurements revealed that no long range diffusion of the implanted Be occurred at 900 or 1100 °C. XRD spectra showed defect-related peaks in the as-implanted samples; these peaks disappeared upon annealing at 900 °C and higher for 10 minutes. Photoluminescence (PL) easurements showed one new line at 3.35 eV which provided strong evidence for the presence of optically active Be acceptors.


1994 ◽  
Vol 101 (7) ◽  
pp. 5865-5874 ◽  
Author(s):  
E. H. Teunissen ◽  
A. P. J. Jansen ◽  
R. A. van Santen ◽  
R. Orlando ◽  
R. Dovesi

As a result of recent experiments, evidence is accumulating that the pene­trating γ -rays from radioactive substances have their origin not in the movement of electrons but in the transitions of α -particles in an excited nucleus. Strong evidence in support of this view was obtained by Rutherford, Ward and Lewis from their analysis of the groups of long range α -particles from radium C', and a more detailed discussion of the results was given by Rutherford and Ellis. This problem of the origin of the γ -rays can be attacked in another direction from a consideration of the so-called fine structure shown by the groups of α -particles emitted by certain radioactive substances. In particular, Rosenblum found that the transformation of thorium C was accompanied by the appearance of five homogeneous groups of α -particles. In explanation of these results, Gamow suggested that γ -rays should be emitted as a result of such a complex transformation, the energies of the individual γ -rays corre­sponding to the differences of energies between the α -particles in the various groups. Unfortunately it is a difficult matter to give a decisive answer on this important question. In a recent paper, Ellis concludes that the experimental evidence is in support of Gamow’s theory, but on the other hand, Meitner as a result of her investigations, has expressed a contrary opinion. It is thus of much impor­tance to examine all methods of obtaining evidence on this question.


1998 ◽  
Vol 537 ◽  
Author(s):  
C. Ronning ◽  
K.J. Linthicum ◽  
E.P. Carlson ◽  
P.J. Hartlieb ◽  
D.B. Thomson ◽  
...  

AbstractSingle crystalline (0001) gallium nitride layers were implanted with beryllium and subsequently annealed within the range of 300-1100°C for 10-60 minutes under a flux of atomic nitrogen obtained using a rf plasma source. The nitrogen flux protected the GaN surface from decomposition in vacuum at high temperatures. SIMS measurements revealed that no long range diffusion of the implanted Be occurred at 900 or 1100°C. XRD spectra showed defect-related peaks in the as-implanted samples; these peaks disappeared upon annealing at 900°C and higher for 10 minutes. Photoluminescence (PL) measurements showed one new line at 3.35 eV which provided strong evidence for the presence of optically active Be acceptors.


Open Biology ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 200356
Author(s):  
Helen Strutt ◽  
David Strutt

Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila : the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway. Components of both of these pathways become asymmetrically localized within cells in response to long-range upstream cues, and form intercellular complexes that link polarity between neighbouring cells. This review examines if and when the two pathways are coupled, focusing on the Drosophila wing, eye and abdomen. There is strong evidence that the pathways are molecularly coupled in tissues that express a specific isoform of the core protein Prickle, namely Spiny-legs. However, in other contexts, the linkages between the pathways are indirect. We discuss how the two pathways act together and independently to mediate a diverse range of effects on polarization of cell structures and behaviours.


Sign in / Sign up

Export Citation Format

Share Document