Tracking the interaction of drug molecules with individual mesoporous amorphous calcium phosphate/ATP nanocomposites – an X-ray spectromicroscopy study

2020 ◽  
Vol 22 (23) ◽  
pp. 13108-13117
Author(s):  
Ying-Ying Jiang ◽  
Zhi-Qiang Wang ◽  
Jia-Tang Chen ◽  
Jun Li ◽  
Ying-Jie Zhu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Adenosine Triphosphate ◽  
Amorphous Calcium Phosphate ◽  
Drug Carrier ◽  
X Ray ◽  
Drug Molecules ◽  
Important Drug

Adenosine triphosphate (ATP) biomolecules play critical roles during the formation of amorphous calcium phosphate composites (ACPC), and ACPC is an important drug carrier due to its significant advantages of biocompatibility and biodegradability.

scholarly journals Comparison of the Efficacy of Different Fluoride Varnishes on Dentin Remineralization During a Critical pH Exposure Using Quantitative X-Ray Microtomography

2018 ◽  
Vol 43 (6) ◽  
pp. E308-E316
Author(s):  
A Sleibi ◽  
A Tappuni ◽  
D Mills ◽  
GR Davis ◽  
A Baysan
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Mineral Content ◽  
Test Group ◽  
Control Group ◽  
Mineral Concentration ◽  
Voxel Size ◽  
X Ray ◽  
Casein Phosphopeptide

SUMMARY Objectives: The objective of this in vitro study was to quantify the amount of mineral change in demineralized dentin at pH 5.5 after the application of dental varnishes containing fluoride with casein phosphopeptide–amorphous calcium phosphate, fluoride and bioglass, or fluoride alone. Methods and Materials: A total of 12 extracted human sound mandibular premolar root samples were coated with an acid-resistant varnish, leaving a 2 × 3 mm window at the outer root surface. These root specimens were then randomly divided into four groups and separately subjected to the demineralizing cycle at a pH of 4.8 for five days to create artificial caries-like lesions in dentin. Subsequently, each sample was imaged using quantitative x-ray microtomography (XMT) at a 15-μm voxel size. Each test group then received one of the following treatments: dental varnish containing casein phosphopeptide–amorphous calcium phosphate and fluoride (CPP-ACP, MI varnish, GC Europe), bioglass and fluoride (BGA, Experimental, Dentsply Sirona), or fluoride alone (NUPRO, Dentsply Sirona), as well as a control group, which received no treatment. These samples were kept in deionized water for 12 hours. The thin layer of varnish was then removed. All samples including the nonvarnish group were subjected to the second demineralizing cycle at pH 5.5 for five days. The final XMT imaging was then carried out following the second demineralizing cycle. XMT scan was also carried out to varnish samples at 25 μm voxel size. The change in mineral concentration in the demineralized teeth was assessed using both qualitative and quantitative image analysis. Results: There was an increase in radiopacity in the subtracted images of all varnish groups; a significant increase in mineral content, 12% for the CPP-ACP and fluoride (p≤0.05 and p≤0.001), 25% BGA (p≤0.001), and 104% fluoride alone varnish (p≤0.001). There was an increase in the size of radiolucency in the lesion area with a significant decrease in mineral content in the nonvarnish group, 10% (p≤0.05 and p≤0.001). Conclusions: There was encouraging evidence of a remineralization effect following the application of dental varnish on dentin and also an observed resistance to demineralization during the acidic challenge in all cases. However, a dental varnish containing fluoride alone appeared to have a much greater effect on dentin remineralization when compared with CPP-ACP with fluoride and bioglass with fluoride.

Preparation of Amorphous Calcium Phosphate/Triclcium Silicate Composite Powders

2009 ◽  
Vol 79-82 ◽  
pp. 1643-1646 ◽  
Author(s):  
Qing Lin ◽  
Yan Bao Li ◽  
Xiang Hui Lan ◽  
Chun Hua Lu ◽  
Zhong Zi Xu
Keyword(s):  
Calcium Phosphate ◽  
Shell Structure ◽  
Amorphous Calcium Phosphate ◽  
Chemical Precipitation ◽  
Precipitation Method ◽  
Core Shell ◽  
X Ray Diffraction ◽  
Composite Powders ◽  
X Ray ◽  
Core Shell Structure

The amorphous calcium phosphate (ACP)/tricalcium silicate (Ca3SiO5, C3S) composite powders were synthesized in this paper. The exothermal behavior of C3S determined by isothermal conduction calorimetry indicated that the ACP could be synthesis by chemical precipitation method during the induction period (stage II) of C3S. The composite powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS). The results indicated that nanosized ACP particles deposited on the surface of C3S particles to form core-shell structure at pH=10.5, and the nCa/nP of ACP could be controlled between 1.0 and 1.5. The core-shell structure is stable after sintered at 500 oC for 3 h to remove the β-cyclodextrin (β-CD). As compared with the irregular C3S particles (1~5 μm), the composite powders particles are spherical with a diameter of 40~150 μm. Therefore, to obtain the smaller size of composite powders, it is expected to avoid the aggregate of C3S particles in the aqueous solution by addition of dispersant. As compared with C3S, the composite powders may contribute better injectability, strength and biocompatibility.

Multifunctional biodegradable mesoporous microspheres of Eu3+-doped amorphous calcium phosphate: microwave-assisted preparation, pH-sensitive drug release, and bioimaging application

2014 ◽  
Vol 2 (41) ◽  
pp. 7132-7140 ◽  
Author(s):  
Feng Chen ◽  
Peng Huang ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
Xin-Yu Zhao ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Drug Release ◽  
Adenosine Triphosphate ◽  
Amorphous Calcium Phosphate ◽  
Solvothermal Method ◽  
Ph Sensitive ◽  
Microwave Assisted ◽  
Mesoporous Microspheres

Mesoporous microspheres of Eu3+-doped amorphous calcium phosphate are prepared using adenosine triphosphate by the microwave solvothermal method.

Porous hollow microspheres of amorphous calcium phosphate: soybean lecithin templated microwave-assisted hydrothermal synthesis and application in drug delivery

2015 ◽  
Vol 3 (9) ◽  
pp. 1823-1830 ◽  
Author(s):  
Guan-Jun Ding ◽  
Ying-Jie Zhu ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
Feng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrothermal Synthesis ◽  
Calcium Phosphate ◽  
Adenosine Triphosphate ◽  
Amorphous Calcium Phosphate ◽  
Soybean Lecithin ◽  
Hollow Microspheres ◽  
Microwave Assisted

Microwave-assisted hydrothermal synthesis of porous hollow microspheres of amorphous calcium phosphate using adenosine triphosphate, CaCl2 and soybean lecithin is reported.

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