From pipemidic acid molecular salts to metal complexes and BioMOFs using mechanochemistry

CrystEngComm ◽  
2021 ◽  
Author(s):  
Martin Zábranský ◽  
Paula C. Alves ◽  
Catarina Bravo ◽  
M. Teresa Duarte ◽  
Vânia André
Keyword(s):  
Metal Complexes ◽  
Pipemidic Acid ◽  
Crystal Forms ◽  
Molecular Salts ◽  
Old Drugs

Mechanochemistry has proven to be an excellent sustainable, efficient and fast tool for the discovery of new crystal forms of old drugs.

Transition metal complexes with the quinolone antibacterial agent pipemidic acid: Synthesis, characterization and biological activity

Polyhedron ◽  
2007 ◽  
Vol 26 (5) ◽  
pp. 1148-1158 ◽  
Author(s):  
Eleni K. Efthimiadou ◽  
Yiannis Sanakis ◽  
Nikos Katsaros ◽  
Alexandra Karaliota ◽  
George Psomas
Keyword(s):  
Biological Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Antibacterial Agent ◽  
Acid Synthesis ◽  
Pipemidic Acid

Crystal Forms of the Antibiotic 4-Aminosalicylic Acid: Solvates and Molecular Salts with Dioxane, Morpholine, and Piperazine

2009 ◽  
Vol 9 (12) ◽  
pp. 5108-5116 ◽  
Author(s):  
Vânia André ◽  
Dario Braga ◽  
Fabrizia Grepioni ◽  
M. Teresa Duarte
Keyword(s):  
Aminosalicylic Acid ◽  
Crystal Forms ◽  
Molecular Salts

The low-resolution 3D-structure of porin, a channel-forming protein in E. coliouter membranes

1983 ◽  
Vol 41 ◽  
pp. 440-441
Author(s):  
A. Engel ◽  
D.L. Dorset ◽  
A. Massalski ◽  
J.P. Rosenbusch
Keyword(s):  
Crystal Packing ◽  
3D Structure ◽  
Gram Negative Bacteria ◽  
Protein Ratio ◽  
Crystal Forms ◽  
Large Molecules ◽  
Functional Studies ◽  
Voltage Dependent ◽  
Planar Membranes ◽  
Hexagonal Arrays

Porins represent a group of channel forming proteins that facilitate diffusion of small solutes across the outer membrane of Gram-negative bacteria, while excluding large molecules (>650 Da). Planar membranes reconstituted from purified matrix porin (OmpF protein) trimers and phospholipids have allowed quantitative functional studies of the voltage-dependent channels and revealed concerted activation of triplets. Under the same reconstitution conditions but using high protein concentrations porin aggregated to 2D lattices suitable for electron microscopy and image processing. Depending on the lipid-to- protein ratio three different crystal packing arrangements were observed: a large (a = 93 Å) and a small (a = 79 Å) hexagonal and a rectangular (a = 79 Å b = 139 Å) form with p3 symmetry for the hexagonal arrays. In all crystal forms distinct stain filled triplet indentations could be seen and were found to be morphologically identical within a resolution of (22 Å). It is tempting to correlate stain triplets with triple channels, but the proof of this hypothesis requires an analysis of the structure in 3 dimensions.

Mechanochemical changes on cyclometalated Ir(iii) acyclic carbene complexes – design and tuning of luminescent mechanochromic transition metal complexes

2020 ◽  
Vol 7 (3) ◽  
pp. 786-794 ◽  
Author(s):  
Jingqi Han ◽  
Kin-Man Tang ◽  
Shun-Cheung Cheng ◽  
Chi-On Ng ◽  
Yuen-Kiu Chun ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Carbene Complexes ◽  
New Class

A new class of luminescent cyclometalated Ir(iii) complexes with readily tunable mechanochromic properties derived from the mechanically induced trans-to-cis isomerization have been developed.

Old Drugs, New Tricks

2009 ◽  
Vol 43 (6) ◽  
pp. 30
Author(s):  
GREG FEERO
Keyword(s):  
Old Drugs
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