Melting point–solubility–structure correlations in chiral and racemic model cocrystals

CrystEngComm ◽  
2020 ◽  
Vol 22 (16) ◽  
pp. 2766-2771 ◽  
Author(s):  
Ornella E. Y. Kilinkissa ◽  
Krishna K. Govender ◽  
Nikoletta B. Báthori
Keyword(s):  
Melting Point ◽  
Intermolecular Interactions ◽  
Building Block ◽  
Aqueous Solubility ◽  
Structure Correlations ◽  
Chiral Building Block ◽  
Packing Efficiency

Comparison of chiral and racemic binary cocrystals showed that the chiral building block limits the formation of certain intermolecular interactions, decreases the packing efficiency, lowers the melting point and increases aqueous solubility.

scholarly journals Total synthesis of biselide A

2021 ◽  
Author(s):  
Venugopal Rao Challa ◽  
Daniel Kwon ◽  
Matthew Taron ◽  
Hope Fan ◽  
Baldip Kang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Building Block ◽  
Chiral Building Block

A total synthesis of the marine macrolide biselide A is described that relies on an enantiomerically enriched α-chloroaldehyde as the sole chiral building block.

Tris(biimidazolato)chromium(III) as a building block for hydrogen-bonded supramolecular assemblies

2006 ◽  
Vol 84 (7) ◽  
pp. 949-959 ◽  
Author(s):  
Letitia M Gruia ◽  
Fernande D Rochon ◽  
André L Beauchamp
Keyword(s):  
Crystal Structure ◽  
Hydrogen Bonding ◽  
Porous Material ◽  
Intermolecular Interactions ◽  
Long Range ◽  
Building Block ◽  
Benzene Molecule ◽  
Methanol Solution ◽  
Solvent Molecules ◽  
Free Material

The trischelate [Cr(H2biim)3](NO3)3 complex of 2,2′-biimidazole (H2biim) was obtained by reacting CrCl3·3THF with [Ag(H2biim)](NO3) in methanol. In the solvent-free material, each ligand forms two N-H···O bonds to a nitrate ion and generates locally neutral [Cr(H2biim)3](NO3)3 units. A methanol solvate was also obtained in which intermolecular interactions involve optimal use of the hydrogen-bonding ability of the [Cr(H2biim)3]3+ cations, NO3– anions, and methanol molecules. In both cases, there is no long-range regular organization of the complex units. Deprotonation of [Cr(H2biim)3](NO3)3 with NaOCH3 yielded neutral Cr(Hbiim)3. Its powder pattern is similar to that of Ru(Hbiim)3, suggesting that it also consists of mutually perpendicular interlocked honeycomb sheets. Recrystallization by slow diffusion of diisopropyl ether into a methanol solution yielded a porous material of composition Cr(Hbiim)3·2.6C6H14O in which superposed honeycomb sheets create infinite channels (~13 Å diameter) filled with disordered solvent molecules. A totally different structure is adopted by the solvate Cr(Hbiim)3·C6H6·2H2O, where the benzene molecule is encapsulated in a cavity created by five complex molecules.Key words: chromium, biimidazole, supramolecular, crystal structure, hydrogen bonding.

scholarly journals CO-CRYSTALS: A REVIEW

2018 ◽  
Vol 8 (6-s) ◽  
pp. 350-358 ◽  
Author(s):  
Shilpa Chaudhari ◽  
Sarika Ankushrao Nikam ◽  
Neetu Khatri ◽  
Shubham Wakde
Keyword(s):  
Melting Point ◽  
Physicochemical Properties ◽  
Spray Drying ◽  
Supercritical Fluid ◽  
Oral Bioavailability ◽  
Aqueous Solubility ◽  
New Product ◽  
Active Pharmaceutical Ingredient ◽  
Pharmacological Properties ◽  
Hot Melt

In development of new product major constraints are poor aqueous solubility and low oral bioavailability. Crystallization is one the approach has been used for enhancement of solubility of poorly aqueous soluble drugs also helps to improve physicochemical properties such as melting point, tabletability, solubility, stability, bioavailability and permeability with preserving the pharmacological properties of the active pharmaceutical ingredient. Different methods have been used for the synthesis of cocrystal such as grinding, slurry, antisolvent, hot melt extrusion, sonocrystallization, supercritical fluid, spray drying etc. The article highlights the co-crystallization, its methods and significance.  

ChemInform Abstract: The (-)-(2S)-Diethyl 2-Hydroxyhexanedioate, a New Chiral Building Block for Enantioselective Synthesis.

ChemInform ◽  
2010 ◽  
Vol 22 (16) ◽  
pp. no-no
Author(s):  
F. BLASER ◽  
P.-F. DESCHENAUX ◽  
T. KALLIMOPOULOS ◽  
A. JACOT-GUILLARMOD
Keyword(s):  
Building Block ◽  
Enantioselective Synthesis ◽  
Chiral Building Block
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