scholarly journals Access to 1-indolyltetrahydro-β-carbolines via metal-free cross-dehydrogenative coupling: the total synthesis of eudistomin U, isoeudistomin U and 19-bromoisoeudistomin U

2021 ◽  
Author(s):  
Ganapathy Ranjani ◽  
Rajagopal Nagarajan
Keyword(s):  
Total Synthesis ◽  
Metal Free ◽  
Dehydrogenative Coupling

A highly selective metal-free CDC approach for the synthesis of 1-indolyltetrahydro-β-carbolines is developed. The total synthesis of biologically important alkaloids, eudistomin U and isoeudistomin U and the first total synthesis of 19-bromoisoeudistomin U were accomplished.

scholarly journals Synthesis of highly substituted fluorenones via metal-free TBHP-promoted oxidative cyclization of 2-(aminomethyl)biphenyls. Application to the total synthesis of nobilone

2021 ◽  
Vol 17 ◽  
pp. 2668-2679
Author(s):  
Ilya A P Jourjine ◽  
Lukas Zeisel ◽  
Jürgen Krauß ◽  
Franz Bracher
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Functional Groups ◽  
Oxidative Cyclization ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Protective Groups

Highly substituted fluorenones are readily prepared in mostly fair to good yields via metal- and additive-free TBHP-promoted cross-dehydrogenative coupling (CDC) of readily accessible N-methyl-2-(aminomethyl)biphenyls and 2-(aminomethyl)biphenyls. This methodology is compatible with numerous functional groups (methoxy, cyano, nitro, chloro, and SEM and TBS-protective groups for phenols) and was further utilized in the first total synthesis of the natural product nobilone.

Metal-Free Visible-Light-Induced C–H/C–H Cross-Dehydrogenative-Coupling of Quinoxalin-2(H)-ones with Simple Ethers

2018 ◽  
Vol 6 (12) ◽  
pp. 17252-17257 ◽  
Author(s):  
Wei Wei ◽  
Leilei Wang ◽  
Huilan Yue ◽  
Pengli Bao ◽  
Weiwei Liu ◽  
...  
Keyword(s):  
Visible Light ◽  
Metal Free ◽  
Dehydrogenative Coupling

ChemInform Abstract: DIAD-Mediated Metal-Free Cross Dehydrogenative Coupling Between Tertiary Amines and α-Fluorinated Sulfones.

ChemInform ◽  
2013 ◽  
Vol 44 (44) ◽  
pp. no-no
Author(s):  
Weizhou Huang ◽  
Chuanfa Ni ◽  
Yanchuan Zhao ◽  
Jinbo Hu
Keyword(s):  
Tertiary Amines ◽  
Metal Free ◽  
Dehydrogenative Coupling

scholarly journals Application of copper(II)-mediated radical cross-dehydrogenative coupling to prepare spirocyclic oxindoles and to a formal total synthesis of Satavaptan

Tetrahedron ◽  
2018 ◽  
Vol 74 (45) ◽  
pp. 6485-6496 ◽  
Author(s):  
Timothy E. Hurst ◽  
Ryan Gorman ◽  
Pauline Drouhin ◽  
Richard J.K. Taylor
Keyword(s):  
Total Synthesis ◽  
Dehydrogenative Coupling
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