Polyselenonium salts: synthesis through sequential selenium-epoxy ‘click’ chemistry and Se-alkylation

2020 ◽  
Vol 56 (91) ◽  
pp. 14271-14274 ◽  
Author(s):  
Taejun Eom ◽  
Anzar Khan
Keyword(s):  
Antibacterial Activity ◽  
Click Chemistry ◽  
Cationic Polymers ◽  
Amphiphilic Homopolymers

With the help of amphiphilic homopolymers, this work explores the ‘click’ nature of the selenium-epoxy reaction, alkylation of the seleno-ethers as a means to prepare cationic polymers, and the antibacterial activity of polyselenonium salts.

scholarly journals Synthesis, Characterization and Bactericidal Activity of a 4-Ammoniumbuthylstyrene-Based Random Copolymer

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1140
Author(s):  
Silvana Alfei ◽  
Gabriella Piatti ◽  
Debora Caviglia ◽  
Anna Maria Schito
Keyword(s):  
Antibacterial Activity ◽  
Bactericidal Activity ◽  
Antimicrobial Agents ◽  
Water Solubility ◽  
Physicochemical Characterization ◽  
Random Copolymer ◽  
Water Soluble ◽  
Cationic Polymers ◽  
Severe Infections

The growing resistance of bacteria to current chemotherapy is a global concern that urgently requires new and effective antimicrobial agents, aimed at curing untreatable infection, reducing unacceptable healthcare costs and human mortality. Cationic polymers, that mimic antimicrobial cationic peptides, represent promising broad-spectrum agents, being less susceptible to develop resistance than low molecular weight antibiotics. We, thus, designed, and herein report, the synthesis and physicochemical characterization of a water-soluble cationic copolymer (P5), obtained by copolymerizing the laboratory-made monomer 4-ammoniumbuthylstyrene hydrochloride with di-methyl-acrylamide as uncharged diluent. The antibacterial activity of P5 was assessed against several multi-drug-resistant clinical isolates of both Gram-positive and Gram-negative species. Except for strains characterized by modifications of the membrane charge, most of the tested isolates were sensible to the new molecule. P5 showed remarkable antibacterial activity against several isolates of genera Enterococcus, Staphylococcus, Pseudomonas, Klebsiella, and against Escherichia coli, Acinetobacter baumannii and Stenotrophomonas maltophilia, displaying a minimum MIC value of 3.15 µM. In time-killing and turbidimetric studies, P5 displayed a rapid non-lytic bactericidal activity. Due to its water-solubility and wide bactericidal spectrum, P5 could represent a promising novel agent capable of overcoming severe infections sustained by bacteria resistant the presently available antibiotics.

Antibacterial activity of cationic polymers: side-chain or main-chain type?

2018 ◽  
Vol 9 (37) ◽  
pp. 4611-4616 ◽  
Author(s):  
Jiangna Guo ◽  
Jing Qin ◽  
Yongyuan Ren ◽  
Bin Wang ◽  
Hengqing Cui ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Small Molecule ◽  
Quaternary Ammonium ◽  
Main Chain ◽  
Side Chain ◽  
Cationic Polymers ◽  
Cationic Compounds ◽  
Chain Type

Imidazolium (Im), quaternary ammonium (Qa), and 1,4-diazabicyclo[2.2.2]octane-1,4-diium (DABCO-diium) cation-based small molecule cationic compounds and their corresponding side-chain/main-chain cationic polymers were synthesized.

scholarly journals Antibacterial Activity of Tannic Acid and Tannic Acid/Amphiphilic Cationic Polymer Mixtures

2020 ◽  
Vol 32 (6) ◽  
pp. 1491-1496
Author(s):  
Fatimah M. Alzahrani ◽  
Stephen G. Yeates ◽  
Michelle Webb ◽  
Hind Ali Alghamdi
Keyword(s):  
Antibacterial Activity ◽  
Tannic Acid ◽  
Cationic Polymer ◽  
Polymer Mixture ◽  
Klebsiella Pneumonia ◽  
Cationic Polymers ◽  
Polymer Mixtures ◽  
Bacterial Strains ◽  
Gram Positive ◽  
E Coli

In this study, the antibacterial activity of tannic acid/amphiphilic cationic polymer (poly{2-[(methacryloyloxy)ethyl]trimethyl-ammonium chloride}, PMADQUAT) and tannic acid mixtures was examined on the strains of Gram-positive (S. aureus) and Gram-negative (E. coli CI2, E. coli K12, Klebsiella pneumonia and P. aeruginosa) bacteria. Tannic acid exhibited the antibacterial activity against all the studied bacterial strains. The ester linkage between glucose and gallic acid is vital for the antimicrobial activity of tannic acid. Tannic acid inhibited the growth of S. aureus and E. coli K12 (1 wt%) and reduced the growth of P. aeruginosa to 23%. Mixing cationic polymers having different structures (statistical copolymer, homopolymer and diblock polymer) with tannic acid lead to an increase in antibacterial activity of tannic acid and the stability and clarity of mixtures was higher than that of a pure tannic acid solution. Tannic acid/diblock polymer and tannic acid/homopolymer mixtures (0.1 wt%) were excellent for inhibiting the growth of planktonic E. coli K12 bacteria, and a low concentration (0.0001 wt%) of tannic acid/diblock polymer reduced its growth to 19%. By contrast, the tannic acid/statistical polymer mixture (0.0001 wt%) was excellent for inhibiting the growth of Gram-positive S. aureus bacteria.

Synthesis of amphiphilic aminated inulin via ‘click chemistry’ and evaluation for its antibacterial activity

2014 ◽  
Vol 24 (18) ◽  
pp. 4590-4593 ◽  
Author(s):  
Fang Dong ◽  
Jun Zhang ◽  
Chunwei Yu ◽  
Qing Li ◽  
Jianming Ren ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Click Chemistry

A Click Chemistry Approach to Pleuromutilin Derivatives, Part 2: Conjugates with Acyclic Nucleosides and Their Ribosomal Binding and Antibacterial Activity

2012 ◽  
Vol 55 (5) ◽  
pp. 2067-2077 ◽  
Author(s):  
Ida Dreier ◽  
Surender Kumar ◽  
Helle Søndergaard ◽  
Maria Louise Rasmussen ◽  
Lykke Haastrup Hansen ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Click Chemistry ◽  
Acyclic Nucleosides

scholarly journals Antibacterial low molecular weight cationic polymers: dissecting the contribution of hydrophobicity, chain length and charge to activity

RSC Advances ◽  
2016 ◽  
Vol 6 (19) ◽  
pp. 15469-15477 ◽  
Author(s):  
James L. Grace ◽  
Johnny X. Huang ◽  
Soon-Ee Cheah ◽  
Nghia P. Truong ◽  
Matthew A. Cooper ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Antibacterial Activity ◽  
Chain Length ◽  
Low Molecular Weight ◽  
Cationic Polymers

We report the antibacterial activity of a novel class of low molecular weight cationic polymers synthesised using Cu(0) mediated polymerisation.

Synthesis, photophysical, antibacterial and molecular docking studies on aromatic ring core-containing rhodamine B decorated triazole bridged dendrimers

2018 ◽  
Vol 42 (24) ◽  
pp. 19390-19399 ◽  
Author(s):  
Jothinathan Sathiya Savithri ◽  
Perumal Rajakumar
Keyword(s):  
Antibacterial Activity ◽  
Molecular Docking ◽  
Click Chemistry ◽  
Aromatic Ring ◽  
Rhodamine B ◽  
First Generation ◽  
Docking Studies ◽  
The Other ◽  
Convergent Approach ◽  
Ring Core

Rhodamine B decorated dendrimers 1–6 were synthesized by a convergent approach using click chemistry. The zeroth generation dendrimer 1 (G0) and the first generation dendrimer 4 (G1) showed better antibacterial activity than the other dendrimers.

scholarly journals Click-based porous cationic polymers for enhanced carbon dioxide capture

2017 ◽  
Vol 5 (1) ◽  
pp. 372-383 ◽  
Author(s):  
Alessandro Dani ◽  
Valentina Crocellà ◽  
Claudio Magistris ◽  
Valentina Santoro ◽  
Jiayin Yuan ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Click Chemistry ◽  
Carbon Dioxide Capture ◽  
Cationic Polymers ◽  
Microporous Polymers

Imidazolium-based porous cationic polymers were synthesized using an innovative and facile approach, which takes advantage of the Debus–Radziszewski reaction to obtain meso-/microporous polymers following click-chemistry principles.

ChemInform Abstract: Synthesis of Novel Heteroarenes Based [1,2,3]-Triazoles via Click Chemistry and Their Evaluation for Antibacterial Activity.

ChemInform ◽  
2012 ◽  
Vol 43 (38) ◽  
pp. no-no
Author(s):  
Davinder Prasad ◽  
Nisha Aggarwal ◽  
Rajesh Kumar ◽  
Mahendra Nath
Keyword(s):  
Antibacterial Activity ◽  
Click Chemistry

scholarly journals Covalent attachment of chitosan to graphene via click chemistry for superior antibacterial activity

2020 ◽  
Vol 1 (4) ◽  
pp. 579-583 ◽  
Author(s):  
Jing Huang ◽  
Zhenyao Yin ◽  
Jinggao Wu
Keyword(s):  
Antibacterial Activity ◽  
Click Chemistry ◽  
Covalent Attachment ◽  
Diazonium Salts ◽  
Graphene Sheets ◽  
Chemically Converted Graphene

Chemically converted graphene sheets are functionalized by treatment with aryl diazonium salts via click chemistry.

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