Direct visualization of the protein corona using carbon nanodots as a specific contrasting agent

2020 ◽  
Vol 56 (88) ◽  
pp. 13599-13602
Author(s):  
Chethana Rao ◽  
Aditya Yadav ◽  
Rimanpreet Kaur ◽  
Amit Prasad ◽  
Chayan Kanti Nandi
Keyword(s):  
Carbon Dots ◽  
Protein Corona ◽  
Carbon Nanodots ◽  
Direct Visualization ◽  
Contrasting Agent

A specific labeling strategy using carbon dots helped in the direct visualization of protein corona under TEM.

scholarly journals Novel properties and applications of carbon nanodots

2018 ◽  
Vol 3 (6) ◽  
pp. 565-597 ◽  
Author(s):  
Lian Xiao ◽  
Handong Sun
Keyword(s):  
Optical Properties ◽  
Carbon Dots ◽  
Carbon Nanodots

Overview of the optical properties and versatile applications of carbon dots.

scholarly journals Tuning the photoluminescence property of carbon dots by ultraviolet light irradiation

RSC Advances ◽  
2019 ◽  
Vol 9 (22) ◽  
pp. 12732-12736 ◽  
Author(s):  
Xiaoyu Li ◽  
Lihe Yan ◽  
Jinhai Si ◽  
Huanhuan Xu ◽  
Yanmin Xu
Keyword(s):  
Surface Modification ◽  
Ultraviolet Light ◽  
Carbon Dots ◽  
Photoluminescence Property ◽  
Light Irradiation ◽  
Carbon Nanodots ◽  
Ultraviolet Light Irradiation

Tuning of the photoluminescence property of carbon nanodots is realized by surface modification through ultraviolet light irradiation.

scholarly journals A study on human serum albumin corona formed on photoluminescent carbon dots

2020 ◽  
Vol 44 (7-8) ◽  
pp. 447-452
Author(s):  
Peng Wang ◽  
Ming Yuan ◽  
Na Li ◽  
Feng Zhang
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Carbon Dots ◽  
Resonance Energy ◽  
Binding Constants ◽  
Protein Corona ◽  
Hybrid Nanomaterial ◽  
Corona Formation ◽  
Biomedical Field

Fluorescence nanostructures have been widely applied in the biomedical field as therapeutic agents and as novel tools for labeling, imaging, and sensing. However, the protein corona will dramatically influence the predesigned properties of nanostructures in serum. Therefore, it is important to understand the mechanism of protein corona formation on nanostructures. Photoluminescent carbon dots have been widely applied in the biomedical field since their discovery. Due to the large overlap between the absorption spectra of proteins and the fluorescence spectra of photoluminescent carbon dots, herein we investigate the mechanism of human serum albumin corona formed on photoluminescent carbon dots using fluorescence resonance energy transfer. By employing spectroscopic methods, the binding constants and the number of binding sites between human serum albumin and photoluminescent carbon dots have been determined, and the corresponding thermodynamics are also discussed as well for the interaction between photoluminescent carbon dots and human serum albumin. In addition, we successfully demonstrate the photoluminescent carbon dots in labeling bean sprouts. We believe that the current research cannot shed light on the mechanism of protein corona formation on nanostructures, but also could benefit the design of hybrid nanomaterial which will be applied to serum environments.

Fluorescent nitrogen-rich carbon nanodots with an unexpected β-C3N4nanocrystalline structure

2016 ◽  
Vol 4 (13) ◽  
pp. 2598-2605 ◽  
Author(s):  
F. Messina ◽  
L. Sciortino ◽  
R. Popescu ◽  
A. M. Venezia ◽  
A. Sciortino ◽  
...  
Keyword(s):  
Crystalline Structure ◽  
Carbon Dots ◽  
Carbon Nanodots ◽  
Nitrogen Doped ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

We report on nitrogen-doped carbon dots having a β-C3N4crystalline structure and yielding bright tunable fluorescence.

scholarly journals Selective two-photon absorption in carbon dots: a piece of the photoluminescence emission puzzle

Nanoscale ◽  
2018 ◽  
Vol 10 (26) ◽  
pp. 12505-12514 ◽  
Author(s):  
Carla I. M. Santos ◽  
Inês F. A. Mariz ◽  
Sandra N. Pinto ◽  
Gil Gonçalves ◽  
Igor Bdikin ◽  
...  
Keyword(s):  
Total Energy ◽  
Carbon Dots ◽  
Emission Spectra ◽  
Photon Absorption ◽  
Carbon Nanodots ◽  
Nonlinear Excitation ◽  
Excitation Mode ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Linear And Nonlinear

Optical spectroscopy of carbon nanodots reveals excitation-mode-dependent emission. Linear and nonlinear excitation at the same total energy results in different emission spectra.

Surface related intrinsic luminescence from carbon nanodots: solvent dependent piezochromism

2019 ◽  
Vol 4 (1) ◽  
pp. 175-181 ◽  
Author(s):  
Pengtao Jing ◽  
Dong Han ◽  
Di Li ◽  
Ding Zhou ◽  
Dezhen Shen ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Diamond Anvil Cell ◽  
Red Shift ◽  
Optical Measurements ◽  
Carbon Nanodots ◽  
Intrinsic Luminescence ◽  
Diamond Anvil

Solvent dependent blue- and red-shift piezochromism of carbon dots were studied by diamond anvil cell with in situ optical measurements.

Quinoline derivative-functionalized carbon dots as a fluorescent nanosensor for sensing and intracellular imaging of Zn2+

2014 ◽  
Vol 2 (31) ◽  
pp. 5020-5027 ◽  
Author(s):  
Zhaomin Zhang ◽  
Yupeng Shi ◽  
Yi Pan ◽  
Xin Cheng ◽  
Lulu Zhang ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Carbon Dots ◽  
Quinoline Derivative ◽  
Carbon Nanodots ◽  
Quinoline Derivatives ◽  
Intracellular Imaging ◽  
Highly Sensitive

Functionalization of carbon nanodots (C-dots) with quinoline derivatives enables a highly sensitive and specific nanosensor for Zn2+ sensing in aqueous solution and Zn2+ imaging in vivo.

Carbon Dots as Nanotherapeutics for Biomedical Application

2020 ◽  
Vol 26 (19) ◽  
pp. 2207-2221 ◽  
Author(s):  
Eemaan N. Cohen ◽  
Pierre P.D. Kondiah ◽  
Yahya E. Choonara ◽  
Lisa C. du Toit ◽  
Viness Pillay
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Carbon Dots ◽  
Water Solubility ◽  
Biomedical Application ◽  
Drug Efficacy ◽  
Cost Effective ◽  
Carbon Nanodots ◽  
Targeted Drug

Carbon nanodots are zero-dimensional spherical allotropes of carbon and are less than 10nm in size (ranging from 2-8nm). Based on their biocompatibility, remarkable water solubility, eco- friendliness, conductivity, desirable optical properties and low toxicity, carbon dots have revolutionized the biomedical field. In addition, they have intrinsic photo-luminesce to facilitate bio-imaging, bio-sensing and theranostics. Carbon dots are also ideal for targeted drug delivery. Through functionalization of their surfaces for attachment of receptor-specific ligands, they ultimately result in improved drug efficacy and a decrease in side-effects. This feature may be ideal for effective chemo-, gene- and antibiotic-therapy. Carbon dots also comply with green chemistry principles with regard to their safe, rapid and eco-friendly synthesis. Carbon dots thus, have significantly enhanced drug delivery and exhibit much promise for future biomedical applications. The purpose of this review is to elucidate the various applications of carbon dots in biomedical fields. In doing so, this review highlights the synthesis, surface functionalization and applicability of biodegradable polymers for the synthesis of carbon dots. It further highlights a myriad of biodegradable, biocompatible and cost-effective polymers that can be utilized for the fabrication of carbon dots. The limitations of these polymers are illustrated as well. Additionally, this review discusses the application of carbon dots in theranostics, chemo-sensing and targeted drug delivery systems. This review also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life.

Sign in / Sign up

Export Citation Format

Share Document