Synthesis of Weinreb amides using diboronic acid anhydride-catalyzed dehydrative amidation of carboxylic acids

2020 ◽  
Vol 56 (86) ◽  
pp. 13145-13148 ◽  
Author(s):  
Naoyuki Shimada ◽  
Naoya Takahashi ◽  
Naoki Ohse ◽  
Masayoshi Koshizuka ◽  
Kazuishi Makino
Keyword(s):  
Carboxylic Acids ◽  
Acid Anhydride ◽  
Weinreb Amides

We have developed a first catalytic methodology for the synthesis of Weinreb amides using dehydrative amidation of carboxylic acids.

scholarly journals Propylphosphonic acid anhydride–mediated amidation of Morita–Baylis–Hillman–derived indolizine-2-carboxylic acids

2021 ◽  
pp. 174751982098715
Author(s):  
Khethobole C Sekgota ◽  
Michelle Isaacs ◽  
Heinrich C Hoppe ◽  
Ronnett Seldon ◽  
Digby F Warner ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Coupling Agent ◽  
Methyl Esters ◽  
Acid Anhydride

Propylphosphonic acid anhydride has been successfully used as a coupling agent in the synthesis of a series of indolizine-2-carboxamido derivatives from indolizine-2-carboxylic acid and its 3-acetylated analogue. The acid substrates were obtained by saponification of the corresponding methyl esters produced, in turn, selectively and efficiently, by time-controlled cyclisation of a single Morita–Baylis–Hillman adduct. Various amino and hydrazino compounds with medicinal potential have been used to prepare indolizine-2-carboxamido and hydrazido derivatives.

A Convenient Method for the Conversion of Hindered Carboxylic Acids toN-Methoxy-N-methyl (Weinreb) Amides

2004 ◽  
Vol 69 (25) ◽  
pp. 8984-8986 ◽  
Author(s):  
Jacqueline C. S. Woo ◽  
Erik Fenster ◽  
Gregory R. Dake
Keyword(s):  
Carboxylic Acids ◽  
Convenient Method ◽  
Weinreb Amides

scholarly journals A Convenient Method of the Conversion of Hindered Carboxylic Acids to N-Methoxy-N-methyl (Weinreb) Amides.

ChemInform ◽  
2005 ◽  
Vol 36 (19) ◽  
Author(s):  
Jacqueline C. S. Woo ◽  
Erik Fenster ◽  
Gregory R. Dake
Keyword(s):  
Carboxylic Acids ◽  
Convenient Method ◽  
Weinreb Amides

One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids

Synthesis ◽  
2013 ◽  
Vol 46 (03) ◽  
pp. 320-330 ◽  
Author(s):  
Danfeng Huang ◽  
Yulai Hu ◽  
Teng Niu ◽  
Ke-Hu Wang ◽  
Changming Xu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free ◽  
Weinreb Amides

scholarly journals Potentiometric Titration and Acid Anhydride Formation of Some Polymeric Carboxylic Acids

1970 ◽  
Vol 27 (303) ◽  
pp. 451-458 ◽  
Author(s):  
Yasuyoshi Sakaguchi ◽  
Katsuyuki Tamaki ◽  
Masayuki Maeda ◽  
Jun Nishino
Keyword(s):  
Carboxylic Acids ◽  
Potentiometric Titration ◽  
Acid Anhydride

ChemInform Abstract: One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids.

ChemInform ◽  
2014 ◽  
Vol 45 (29) ◽  
pp. no-no
Author(s):  
Teng Niu ◽  
Ke-Hu Wang ◽  
Danfeng Huang ◽  
Changming Xu ◽  
Yingpeng Su ◽  
...  
Keyword(s):  
Transition Metal ◽  
Carboxylic Acids ◽  
One Pot ◽  
Metal Free ◽  
Weinreb Amides
Sign in / Sign up

Export Citation Format

Share Document