One-pot synthesis of template-free hollow anisotropic CaCO3 structures: towards inorganic shape-mimicking drug delivery systems

2020 ◽  
Vol 56 (80) ◽  
pp. 11969-11972
Author(s):  
Nikita Serov ◽  
Darina Darmoroz ◽  
Alina Lokteva ◽  
Ivan Chernyshov ◽  
Elena Koshel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Release Behavior ◽  
One Pot ◽  
One Pot Synthesis ◽  
Template Free

A template-free approach for the formulation of hollow bacteria-like CaCO3-based pH-sensitive drug delivery systems (DDSs) with controllable anisotropy and click-release behavior is developed to make a step towards shape-mimicking DDSs.

Recent Progress in Stimuli Responsive Intelligent Nano Scale Drug Delivery Systems: A special focus towards pH sensitive systems

2021 ◽  
Vol 22 ◽  
Author(s):  
Vaidevi Sethuraman ◽  
Kumar Janakiraman ◽  
Venkateshwaran Krishnaswami ◽  
Ruckmani Kandasamy
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Disease Diagnosis ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Special Focus ◽  
Stimuli Responsive ◽  
Ph Variation ◽  
Responsive Systems

Abstract: Stimuli responsive nanocarriers are gaining much attention due to its versatile multifunctional activities including disease diagnosis and treatment. Recently, clinical applications of nano drug delivery systems for cancer treatment make a considerable challenge due to its limited cellular uptake, low bioavailability, poor targetability, stability issues, and unfavourable pharmacokinetics. To overcome these issues researchers are focussing on stimuli responsive systems. Nano carriers elicit its role through endogenous (pH, temperature, enzyme and redox) or exogenous (temperature, light, magnetic field, ultrasound) stimulus. These systems were designed to overcome the shortcomings such as non-specificity and toxicity associated with the conventional drug delivery systems. The pH variation between healthy cells and tumor microenvironment creates a platform towards the generation of pH sensitive nano delivery systems. Herein, we propose to present an overview of various internal and external stimuli responsive behavior based drug delivery systems. Herein the present review will focus specifically on the significance of various pH- responsive nanomaterials such as polymeric nanoparticles, nano micelles, inorganic based pH sensitive drug delivery carriers such as calcium phosphate nanoparticles, and carbon dots in cancer treatment. Moreover, this review elaborates the recent findings on pH based stimuli responsive drug delivery system with special emphasis towards our reported stimuli responsive systems for cancer treatment.

pH-sensitive drug delivery systems by radical polymerization of gelatin derivatives

2012 ◽  
Vol 125 (4) ◽  
pp. 3006-3013 ◽  
Author(s):  
I. Altimari ◽  
U. G. Spizzirri ◽  
F. Iemma ◽  
M. Curcio ◽  
F. Puoci ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Radical Polymerization ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Sensitive

Composite microparticle drug delivery systems based on chitosan, alginate and pectin with improved pH-sensitive drug release property

2009 ◽  
Vol 68 (2) ◽  
pp. 245-249 ◽  
Author(s):  
Cui-Yun Yu ◽  
Bo-Cheng Yin ◽  
Wei Zhang ◽  
Si-Xue Cheng ◽  
Xian-Zheng Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Ph Sensitive ◽  
Release Property
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