Regioselective benzannulation of allylic sulfur ylides with ynones: a rapid access to substituted thioanisoles

2020 ◽  
Vol 56 (87) ◽  
pp. 13457-13460
Author(s):  
Matam Parameshwar ◽  
Maneesh Kumar Reddy Singam ◽  
Attunuri Nagireddy ◽  
Jagadeesh Babu Nanubolu ◽  
Maddi Sridhar Reddy
Keyword(s):  
Sulfur Ylides ◽  
Sulphur Source ◽  
Rapid Access

A novel benzannulation of allyl sulfer ylide (ASY) with alkynones is accomplished for highly regioselective formation of multi substituted thioanisoles where ASY was rarely found to be a 3C component as well as a sulphur source.

Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products

2019 ◽  
Author(s):  
De-Wei Gao ◽  
Yang Gao ◽  
Huiling Shao ◽  
Tian-Zhang Qiao ◽  
Xin Wang ◽  
...  
Keyword(s):  
Organic Synthesis ◽  
Medicinal Chemistry ◽  
Proteasome Inhibitors ◽  
Building Blocks ◽  
Unique Role ◽  
Efficient Strategy ◽  
Carbon Centers ◽  
Rapid Access ◽  
Cascade Catalysis ◽  
Privileged Scaffolds

Enantioenriched <i>α</i>-aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks in organic synthesis. Recently, CuH-catalyzed asymmetric alkene hydrofunctionalization has become a powerful tool to construct stereogenic carbon centers. In contrast, applying CuH cascade catalysis to achieve reductive 1,1-difunctionalization of alkynes remains an important, but largely unaddressed, synthetic challenge. Herein, we report an efficient strategy to synthesize <i>α</i>-aminoboronates <i>via </i>CuH-catalyzed hydroboration/hydroamination cascade of readily available alkynes. Notably, this transformation selectively delivers the desired 1,1-heterodifunctionalized product in favor of alternative homodifunctionalized, 1,2-heterodifunctionalized, or reductively monofunctionalized byproducts, thereby offering rapid access to these privileged scaffolds with high chemo-, regio- and enantioselectivity.<br>

Rapid Access of New Pyranocarbazole Derivatives Under Microwave Irradiation

2019 ◽  
Vol 5 (2) ◽  
pp. 104-110
Author(s):  
Pedavenkatagari N. Reddy ◽  
Pannala Padmaja
Keyword(s):  
Microwave Irradiation ◽  
Rapid Access

155 Evaluation of the Rapid Access Chest Pain Clinic Service

Heart ◽  
2015 ◽  
Vol 101 (Suppl 4) ◽  
pp. A89.1-A89
Author(s):  
Ho Tin Wong ◽  
Alexander Daniel Simms ◽  
Mirza Wazir Baig ◽  
Klaus Karl Witte
Keyword(s):  
Chest Pain ◽  
Pain Clinic ◽  
Rapid Access

A brief report on rapid access to medication assisted treatment

2021 ◽  
pp. 1-8
Author(s):  
Daniel Baslock ◽  
Barbara Gramuglia ◽  
Alice Spirito ◽  
Javad Mashkuri ◽  
Victoria Stanhope
Keyword(s):  
Medication Assisted Treatment ◽  
Rapid Access

Diastereoselective [3 + 1] Cyclization Reaction of Oxindolyl Azaoxyallyl Cations with Sulfur Ylides: Assembly of 3,3′-Spiro[β-lactam]-oxindoles

2021 ◽  
Vol 23 (4) ◽  
pp. 1451-1456
Author(s):  
Hai-Jun Leng ◽  
Qing-Zhu Li ◽  
Peng Xiang ◽  
Ting Qi ◽  
Qing-Song Dai ◽  
...  
Keyword(s):  
Cyclization Reaction ◽  
Sulfur Ylides

Visible-light-induced remote C(sp3)-H sulfonylvinylation: assembly of cyanoalkylated vinyl sulfones

2021 ◽  
Author(s):  
Ping Bao ◽  
Feiyan Yu ◽  
Fu-Sheng He ◽  
Zhimei Tang ◽  
Wei-Ping Deng ◽  
...  
Keyword(s):  
Visible Light ◽  
Rapid Access ◽  
Three Component Reaction ◽  
Propargyl Alcohols

A photoinduced sulfonylvinylation of unactivated C(sp3)-H bond through a three-component reaction of propargyl alcohols, potassium metabisulfite and cycloketone oxime esters is developed. This approach enables rapid access to cyanoalkylated vinyl...

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