Photo-switching of blunt-end stacking between DNA strands immobilized on gold nanoparticles

2020 ◽  
Vol 56 (93) ◽  
pp. 14589-14592
Author(s):  
Naoki Kanayama ◽  
Satomi Kishi ◽  
Tohru Takarada ◽  
Mizuo Maeda
Keyword(s):  
Gold Nanoparticles ◽  
Base Pairing ◽  
Azobenzene Moiety ◽  
Dna Strands ◽  
End To End

End-to-end stacking of DNAs on gold nanoparticles was switched by terminal base pairing/unpairing triggered by the photo-isomerization of an azobenzene moiety nearby the DNA terminal.

Colorimetric Detection of DNA Strands on Cellulose Microparticles Using ZZ–CBM Fusions and Gold Nanoparticles

2019 ◽  
Vol 14 (8) ◽  
pp. 1800590
Author(s):  
Ana M. M. Rosa ◽  
Maria R. Nazaré ◽  
Duarte M. F. Prazeres
Keyword(s):  
Gold Nanoparticles ◽  
Colorimetric Detection ◽  
Dna Strands

scholarly journals Development of Gold-PAGE: towards the electrophoretic analysis of sulphurous biopolymers

2019 ◽  
Vol 7 (34) ◽  
pp. 5156-5160 ◽  
Author(s):  
Emerald R. Taylor ◽  
Silvia Cavuoto ◽  
David M. Beal ◽  
Sophie Caujolle ◽  
Adrian Podoleanu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Electrophoretic Analysis ◽  
Polyacrylamide Electrophoresis ◽  
Dna Strands

Gold nanoparticles, encapsulated within polyacrylamide electrophoresis gels, can discriminate between number of type of sulphur modifications in DNA strands.

Detection of electrical characteristics of DNA strands immobilized on self-assembled multilayer gold nanoparticles

2006 ◽  
Vol 89 (20) ◽  
pp. 203902 ◽  
Author(s):  
Chien-Ying Tsai ◽  
Tien-Li Chang ◽  
Long-Sheng Kuo ◽  
Ping-Hei Chen
Keyword(s):  
Gold Nanoparticles ◽  
Electrical Characteristics ◽  
Dna Strands ◽  
Self Assembled

Bioconjugates Containing Ferritin and Metal Nanoparticles

2012 ◽  
Vol 463-464 ◽  
pp. 833-836
Author(s):  
Bin Zheng ◽  
Mutsunori Uenuma ◽  
Yukiharu Uraoka ◽  
Ichiro Yamashita
Keyword(s):  
Gold Nanoparticles ◽  
Metal Nanoparticles ◽  
Inorganic Nanoparticles ◽  
Base Pairing ◽  
Dna Base

Novel assemblies of gold nanoparticles or gold nanoparticles with other inorganic nanoparticles have received considerable interest due to their fascinating properties desired for various detection applications. Here we present a bioconjugate containing ferritin and gold nanoparticles. In this bioconjugate, there is a central ferritin, and a several gold nanoparticles are located around by DNA base-pairing.

Multiway Investigation of Interaction between Fluorescence Labeled DNA Strands and Unmodified Gold Nanoparticles

2012 ◽  
Vol 84 (15) ◽  
pp. 6603-6610 ◽  
Author(s):  
Yousef Akhlaghi ◽  
Mohsen Kompany-Zareh ◽  
Mohammad Reza Hormozi-Nezhad
Keyword(s):  
Gold Nanoparticles ◽  
Dna Strands

A Molecule Computing Model for Maximum Independent Set Problem Based on DNA/AuNP Conjugation

2013 ◽  
Vol 690-693 ◽  
pp. 445-449
Author(s):  
Jing Yang ◽  
Cheng Zhang ◽  
Hao Wang
Keyword(s):  
Gold Nanoparticles ◽  
Dna Computing ◽  
Independent Set ◽  
Maximum Independent Set ◽  
Independent Set Problem ◽  
Computing Model ◽  
Interdisciplinary Field ◽  
Dna Strands ◽  
Dna Strand ◽  
Maximum Independent Set Problem

With the progress of DNA computing and nanotechnology, DNA/AuNP conjugation becomes an emerging interdisciplinary field. In this paper, a novel DNA computing model based on DNA/AuNP conjugation is developed to solve a maximum independent set problem (MIS). Making use of the hybridization between long DNA strands and short strands conjugated with gold nanoparticles, a series of searching process is implemented. After that, based on the number of DNA/AuNP conjugation on one DNA strand, the answer of the MIS is obtained. To verify the proposed algorithm, a simple paradigm is calculated by using the DNA computing model. In this model, there are some significant advantages such as easy detecting, and controllable automation. This work may demonstrate that DNA computing has the great potentiality in huge parallelism computation.

CIRCULAR ARRANGEMENT OF AZOBENZENE CHROMOPHORES IN THE NUCLEOAMPHIPHILE MONOLAYER BY BASE-PAIRING WITH CYCLIC DNA

2002 ◽  
Vol 01 (05n06) ◽  
pp. 677-681 ◽  
Author(s):  
JIN NISHIDA ◽  
JIN MATSUMOTO ◽  
MITSUHIKO MORISUE ◽  
KUNIHARU IJIRO ◽  
MASATSUGU SHIMOMURA
Keyword(s):  
Absorption Spectra ◽  
Absorption Maximum ◽  
Base Pairing ◽  
Parallel Orientation ◽  
Azobenzene Moiety ◽  
Circular Arrangement ◽  
J Aggregates ◽  
Azobenzene Groups ◽  
Adenine Derivative

In order to construct chromophores arrays that precisely controlled their arrangement, monolayers of an azobenzene bearing nucleoamphiphile were prepared on various oligoDNA solutions. Monolayers of the amphiphilic adenine derivative bearing an azobenzene moiety ( C 12 AzoC 5 Ade ) were prepared on thymidylic acid tetramer (dT4) and octamer (dT8) solutions, and UV-vis reflection absorption spectra of the monolayers were measured to investigate aggregation structures of the azobenzene. The absorption maximum of the monolayer was blue-shifted on the dT4 solution and red-shifted on the dT8 solution. It shows that azobenzene groups in the monolayer have parallel orientation (H aggregate) on the dT4 solution. Though, azobenzene groups have head-to-tail orientation (J aggregates) on the dT8 solution. When monolayers of C 12 AzoC 5 Ade were prepared on the synthesized cyclic oligonucleotides, the absorption spectra were totally different from those of the corresponding linear oligonucleotides.

scholarly journals ID: 1044 DNA origami nanobot for sensitive drug delivery chemotherapy

2017 ◽  
Vol 4 (S) ◽  
pp. 124
Author(s):  
Minh Tri Luu ◽  
Shelley Wickham ◽  
Ali Abbas
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Drug Delivery Systems ◽  
Heating Time ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Dna Origami ◽  
Drug Molecules ◽  
Dna Strands

The cutting-edge technology of constructing nanoscale objects using DNA origami has opened new directions for drug delivery in cancer chemotherapy research [1, 2]. This project aims to develop a novel DNA origami nanobot for drug delivery, with high selectivity and specificity for chemotherapy. It is important to be able to control the rate of drug release to maintain the concentration of chemotherapeutic agents at the desirable set-point [3]. This control can be achieved through various activation methods, similar to those used in liposome drug delivery systems, e.g. magnetism, radiation, ultrasound, heating etc. [4]. These stimuli can deliver specific types of energy (e.g. thermal), which can then activate a pre-designed nanobot- topology variation. For example, thermal energy can cause local DNA strands to melt and partially distort some local regions of the DNA topology, releasing drug molecules. One mechanism to activate the drug release is via radio frequency (RF) electromagnetic wave induced heating of gold nanoparticles [6]. A prototype nanobot will be developed and tested for heat-triggered nanobot switching between open and closed configurations. It is hypothesized that upon RF heating, the gold nanoparticles will concentrate the heat and cause the local DNA strands to melt, leading to the open configuration, without melting the rest of the nanobot structure. Heating time and power will be tuned to regulate the drug release rate. This work will develop an effective process control strategy for enhanced performance of nanoscale drug delivery systems.

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