scholarly journals Sequence-defined vinyl sulfonamide click nucleic acids (VS-CNAs) and their assembly into dynamically responsive materials

2020 ◽  
Vol 56 (76) ◽  
pp. 11263-11266
Author(s):  
Bryan P. Sutherland ◽  
Paige J. LeValley ◽  
Derek J. Bischoff ◽  
April M. Kloxin ◽  
Christopher J. Kloxin
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry ◽  
Polymer Support ◽  
Soluble Polymer ◽  
Responsive Materials ◽  
Synthetic Strategy ◽  
The Creation

A scalable synthetic strategy was developed towards the creation of sequence-defined DNA analogues employing thiol-Michael click chemistry and a soluble polymer support.

scholarly journals A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids

2021 ◽  
Author(s):  
Nicolò Zuin Fantoni ◽  
Afaf H. El-Sagheer ◽  
Tom Brown
Keyword(s):  
Nucleic Acids ◽  
Click Chemistry

scholarly journals Modified Nucleosides, Nucleotides and Nucleic Acids via Click Azide-Alkyne Cycloaddition for Pharmacological Applications

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3100
Author(s):  
Daniela Perrone ◽  
Elena Marchesi ◽  
Lorenzo Preti ◽  
Maria Luisa Navacchia
Keyword(s):  
Cancer Therapy ◽  
Nucleic Acids ◽  
Click Chemistry ◽  
Nucleoside Analogs ◽  
Modified Nucleosides ◽  
Biological Molecules ◽  
Dipolar Cycloaddition ◽  
Virus Diseases ◽  
Reaction Conditions ◽  
Hybrid Compounds

The click azide = alkyne 1,3-dipolar cycloaddition (click chemistry) has become the approach of choice for bioconjugations in medicinal chemistry, providing facile reaction conditions amenable to both small and biological molecules. Many nucleoside analogs are known for their marked impact in cancer therapy and for the treatment of virus diseases and new targeted oligonucleotides have been developed for different purposes. The click chemistry allowing the tolerated union between units with a wide diversity of functional groups represents a robust means of designing new hybrid compounds with an extraordinary diversity of applications. This review provides an overview of the most recent works related to the use of click chemistry methodology in the field of nucleosides, nucleotides and nucleic acids for pharmacological applications.

Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support

2010 ◽  
Vol 15 (2) ◽  
pp. 569-581 ◽  
Author(s):  
Kaushik Chanda ◽  
Cheng-Ting Chou ◽  
Jin-Ji Lai ◽  
Shu-Fen Lin ◽  
Gorakh S. Yellol ◽  
...  
Keyword(s):  
Polymer Support ◽  
Soluble Polymer

Diastereoselective Synthesis of trans β-Lactams on Soluble Polymer Support

Synthesis ◽  
2006 ◽  
Vol 2006 (11) ◽  
pp. 1829-1835
Author(s):  
Yan-Guang Wang ◽  
Shan-Zhong Jian ◽  
Qing Yuan
Keyword(s):  
Polymer Support ◽  
Diastereoselective Synthesis ◽  
Soluble Polymer

Synthesis of Thiophene Derivatives on Soluble Polymer-Support Using Gewald Reaction

Synthesis ◽  
2004 ◽  
pp. 3055-3059 ◽  
Author(s):  
Guichun Yang ◽  
Haiqing Zhang ◽  
Jianian Chen ◽  
Zuxing Chen
Keyword(s):  
Polymer Support ◽  
Soluble Polymer ◽  
Gewald Reaction ◽  
Thiophene Derivatives

scholarly journals Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 432 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
María Vallet-Regí
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Nucleic Acids ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Action ◽  
The Creation

The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very different nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action. Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.

Terminal functionalization of atactic polypropylene: a new soluble polymer support

2013 ◽  
Vol 54 (8) ◽  
pp. 970-974 ◽  
Author(s):  
Binhong Lin ◽  
Devin Lawler ◽  
Gregory P. McGovern ◽  
Christopher A. Bradley ◽  
Christopher E. Hobbs
Keyword(s):  
Polymer Support ◽  
Atactic Polypropylene ◽  
Soluble Polymer
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