scholarly journals DNA-specific selectivity in pairing of model nucleobases in the solid state

2020 ◽  
Vol 56 (88) ◽  
pp. 13524-13527 ◽  
Author(s):  
Tomislav Stolar ◽  
Stipe Lukin ◽  
Martin Etter ◽  
Maša Rajić Linarić ◽  
Krunoslav Užarević ◽  
...  
Keyword(s):  
Solid State ◽  
Reaction Medium ◽  
Selective Recognition ◽  
Specific Selectivity

Solid-state may serve as the reaction medium for selective recognition between model nucleobases.

scholarly journals Preparation of Li3PS4–Li3PO4 Solid Electrolytes by Liquid-Phase Shaking for All-Solid-State Batteries

2021 ◽  
Vol 2 (1) ◽  
pp. 39-48
Author(s):  
Nguyen H. H. Phuc ◽  
Takaki Maeda ◽  
Tokoharu Yamamoto ◽  
Hiroyuki Muto ◽  
Atsunori Matsuda
Keyword(s):  
Solid Solution ◽  
Solid State ◽  
Liquid Phase ◽  
Room Temperature ◽  
Reaction Medium ◽  
Magic Angle Spinning ◽  
Resonance Spectroscopy ◽  
Synthesis Methods ◽  
Magic Angle ◽  
Angle Spinning

A solid solution of a 100Li3PS4·xLi3PO4 solid electrolyte was easily prepared by liquid-phase synthesis. Instead of the conventional solid-state synthesis methods, ethyl propionate was used as the reaction medium. The initial stage of the reaction among Li2S, P2S5 and Li3PO4 was proved by ultraviolet-visible spectroscopy. The powder X-ray diffraction (XRD) results showed that the solid solution was formed up to x = 6. At x = 20, XRD peaks of Li3PO4 were detected in the prepared sample after heat treatment at 170 °C. However, the samples obtained at room temperature showed no evidence of Li3PO4 remaining for x = 20. Solid phosphorus-31 magic angle spinning nuclear magnetic resonance spectroscopy results proved the formation of a POS33− unit in the sample with x = 6. Improvements of ionic conductivity at room temperature and activation energy were obtained with the formation of the solid solution. The sample with x = 6 exhibited a better stability against Li metal than that with x = 0. The all-solid-state half-cell employing the sample with x = 6 at the positive electrode exhibited a better charge–discharge capacity than that employing the sample with x = 0.

Direct Synthesis of Deep Cavity p-Phenylcalix[4]arene in Poly(Ethylene Glycol), and its Self-Association in the Solid State

2006 ◽  
Vol 59 (4) ◽  
pp. 260 ◽  
Author(s):  
Mohamed Makha ◽  
Colin L. Raston ◽  
Alexandre N. Sobolev
Keyword(s):  
Solid State ◽  
Ethylene Glycol ◽  
Direct Synthesis ◽  
Reaction Medium ◽  
State Structure ◽  
Poly Ethylene Glycol ◽  
Solid State Structure ◽  
Deep Cavity ◽  
Self Association ◽  
Poly Ethylene

p-Phenylcalix[4]arene is formed directly from p-phenylphenol in 66% yield (50% isolated yield) using poly(ethylene glycol) as the reaction medium, with crystallization of the pure cavitand from toluene mediated by p-carborane. The solid-state structure comprises interlocking columnar arrays.

Controlling the regioselectivity of the di-π-methane rearrangements of 1,2-naphtho-annelated barrelene derivatives — Solution versus solid-state photochemistry

2009 ◽  
Vol 87 (5) ◽  
pp. 619-626 ◽  
Author(s):  
Jia Luo ◽  
Heiko Ihmels ◽  
Hans-Jörg Deiseroth ◽  
Marc Schlosser
Keyword(s):  
Solid State ◽  
Transition State ◽  
Crystal Lattice ◽  
Reaction Medium ◽  
Product Distribution ◽  
Solution Versus ◽  
Selective Stabilization ◽  
Steric Constraints

The synthesis of 1,2-naphtho-annelated barrelene derivatives, namely dimethyl-7,12-dihydro-7,12-ethenobenzo[a]anthracene-13,14-dicarboxylate (4a) and dimethyl-7,14-dihydro-7,14-ethenodibenzo[a,j]-anthracene-15,16-dicarboxylate (4b), and the investigation of their photoreactivity in solution and in the solid state is reported. The irradiation of 4a and 4b resulted in regioselective di-π-methane rearrangements to give semibullvalene products; however, the product distribution is inverted upon changing the reaction medium from solution to the solid state. In solution, an α-naphtho–vinyl bridging predominates as the initial photochemical step because of the selective stabilization of the corresponding transition state, as discussed on the basis of the structures of the related biradical intermediates, whereas the solid-state photoreaction is significantly influenced by the steric constraints within the crystal lattice that only allow a β-naphtho–vinyl bridging.

scholarly journals Selective Nucleobase Pairing Extends Plausibly Prebiotic Conditions to the Solid State

2019 ◽  
Author(s):  
Tomislav Stolar ◽  
Stipe Lukin ◽  
Maša Rajić Linarić ◽  
Martin Etter ◽  
Krunoslav Užarević ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Solid State ◽  
Supramolecular Chemistry ◽  
Self Assembly ◽  
Reaction Medium ◽  
Component Mixture ◽  
Dry Heating ◽  
Dna Specificity ◽  
Emergence Of Life

Despite its immense relevance in the context of the emergence of life, the pairing of nucleobases has only been observed for regioselectively methylated adenine and thymine. This is surprising as it raises the question why would nucleobases be incorporated into DNA if they were unable to self-assemble beforehand. Here, we have discovered that elusive pairing of methylated guanine and cytosine is readily available in the solid state by heating, where the two nucleobases self-assemble via Watson-Crick hydrogen-bonding. Dry heating preserves DNA-specificity as a four-component mixture of nucleobases provides self-assembly only of complementary pairs. We thus emphasize the importance of the solid state as the reaction medium, even for the supramolecular chemistry of life, which was thus far underexplored in the prebiotic context.<br>

Selective recognition of “solvent” molecules in solution and the solid state by 1,4-dimethoxypillar[5]arene driven by attractive forces

2014 ◽  
Vol 38 (2) ◽  
pp. 845 ◽  
Author(s):  
Li-Li Tan ◽  
Yumo Zhang ◽  
Bao Li ◽  
Kai Wang ◽  
Sean Xiao-An Zhang ◽  
...  
Keyword(s):  
Solid State ◽  
Selective Recognition ◽  
Solvent Molecules

Development of Highly Specific and Selectively Recognizing Caffeine Imprinted Polymer nanomaterials with EGDMA Crosslinker

2021 ◽  
Vol 06 ◽  
Author(s):  
Renuka Suravajhala ◽  
Harshavardhan Reddy Burri ◽  
Babita Malik
Keyword(s):  
Spectral Analysis ◽  
Ethylene Glycol ◽  
Molecularly Imprinted Polymer ◽  
Selective Recognition ◽  
Cross Linking ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Specific Selectivity

Aims: The present study focused on selective recognition of caffeine-specific cavities in the molecularly imprinted polymer (MIP) networks. Background: The degree of crosslinking was optimized based on the template to study the rebinding capacity. Objective: The objective of the study was to selectively recognize the caffeine-specific cavities in the molecularly imprinted polymer (MIP) networks. Methods: A self-assembled co-polymerization with functional monomers (FM) as methyl acrylamide (MAA), ethylene glycol dimethyl acrylate (EDMA), cross-linking in 1:20, 40:60 ratio of FM: crosslinker, leads to caffeine with/without networks in imprinted polymers. Furthermore, the synthesized imprinted nano polymers were characterized by UV-VIS, FTIR, GC-MS, and SEM spectral analysis. The specific selective binding of caffeine and its analogues as hydrazone, naphthalene, and hypoxanthine were investigated. Results and Conclusion: It was proved from rebinding studies that imprinted nanomaterials polymers with 1:10:20, 40, and 60 (template:FM: crosslinker) had 62-70% maximum specific selectivity with particle 30-50 nm and 60-92 nm for synthesized MIPs/NIPs, respectively.

scholarly journals Selective Nucleobase Pairing Extends Plausibly Prebiotic Conditions to the Solid State

2019 ◽  
Author(s):  
Tomislav Stolar ◽  
Stipe Lukin ◽  
Maša Rajić Linarić ◽  
Martin Etter ◽  
Krunoslav Užarević ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Solid State ◽  
Supramolecular Chemistry ◽  
Self Assembly ◽  
Reaction Medium ◽  
Component Mixture ◽  
Dry Heating ◽  
Dna Specificity ◽  
Emergence Of Life

Despite its immense relevance in the context of the emergence of life, the pairing of nucleobases has only been observed for regioselectively methylated adenine and thymine. This is surprising as it raises the question why would nucleobases be incorporated into DNA if they were unable to self-assemble beforehand. Here, we have discovered that elusive pairing of methylated guanine and cytosine is readily available in the solid state by heating, where the two nucleobases self-assemble via Watson-Crick hydrogen-bonding. Dry heating preserves DNA-specificity as a four-component mixture of nucleobases provides self-assembly only of complementary pairs. We thus emphasize the importance of the solid state as the reaction medium, even for the supramolecular chemistry of life, which was thus far underexplored in the prebiotic context.<br>

Selective Nucleobase Pairing Extends Plausible Prebiotic Conditions to the Solid State

2019 ◽  
Author(s):  
Tomislav Stolar ◽  
Stipe Lukin ◽  
Maša Rajić Linarić ◽  
Martin Etter ◽  
Krunoslav Užarević ◽  
...  
Keyword(s):  
Solid State ◽  
Molecular Recognition ◽  
Ternary Mixture ◽  
Reaction Medium ◽  
X Ray Diffraction ◽  
Base Pairs ◽  
X Ray ◽  
Quaternary Mixture ◽  
Molecular Selection ◽  
Self Assembled

<div>Pairing of complementary nucleobases is the most famous example of molecular recognition. However, it has long been known that except 9-methyladenine (9-mA) and 1-methylthymine (1-mT), all other binary combinations of nucleobases do not form base pairs under plausible prebiotic conditions, e.g., in water or in the solid state. It is surprising that nucleobases would have been incorporated into DNA if they were unable to self-assemble prior to their attachment. Here we show how the formation of an elusive base pair between 9-methylguanine (9-mG) and 1-methylcytosine (1-mC) is possible in the solid state via Watson-Crick hydrogen bonding. Molecular recognition of 9-mG:1-mC as well as 9-mA:1-mT base pairs was observed by X-ray diffraction monitoring during heating their 1:1 solid mixtures, while all other binary mixtures failed to give base pairs. To demonstrate the selectivity of complementary nucleobase pairing, we showed how 9-mA and 1-mT self-assembled in ternary mixture containing also 1-methyluracil (1-mU), and both 9-mA:1-mT and 9-mG:1-mC pairs self-assembled in quaternary mixture. The results presented here indicate the importance that the solid state as a reaction medium might have had as a prebiotic molecular selection tool towards compatibility as found in the DNA.</div>

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