Ir-catalyzed selective dehydrogenative cross-coupling of aryls with o-carboranes via a mixed directing-group strategy

2020 ◽  
Vol 56 (51) ◽  
pp. 7001-7004 ◽  
Author(s):  
Yu Chen ◽  
Yangjian Quan ◽  
Zuowei Xie
Keyword(s):  
Cross Coupling ◽  
Group Strategy ◽  
Dehydrogenative Coupling ◽  
Directing Group

Ir-catalyzed highly selective B–H/C–H cross dehydrogenative coupling between o-carboranes and (hetero)aryls has been achieved using a mixed directing-group strategy.

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

2019 ◽  
Author(s):  
Ming Shang ◽  
Karla S. Feu ◽  
Julien C. Vantourout ◽  
Lisa M. Barton ◽  
Heather L. Osswald ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Heterocyclic Compounds ◽  
Cross Coupling ◽  
Building Blocks ◽  
Enantioselective Synthesis ◽  
Carbon Centers ◽  
Drug Candidates ◽  
Rapid Diversification ◽  
Directing Group ◽  
Compound Series

<div> <div> <div> <p>The union of two powerful transformations, directed C–H activation and decarboxylative cross-coupling, for the enantioselective synthesis of vicinally functionalized alkyl, carbocyclic, and heterocyclic compounds is described. Starting from simple carboxylic acid building blocks, this modular sequence exploits the residual directing group to access more than 50 scaffolds that would be otherwise extremely difficult to prepare. The tactical use of these two transformations accomplishes a formal vicinal difunctionalization of carbon centers in a way that is modular and thus amenable to rapid diversity incorporation. A simplification of routes to known preclinical drug candidates is presented along with the rapid diversification of an antimalarial compound series. </p> </div> </div> </div>

Transition-Metal-Free Synthetic Strategies for the Cross-Coupling Reactions in Water: A Green Approach

2020 ◽  
Vol 07 ◽  
Author(s):  
Tanmay Chatterjee ◽  
Nilanjana Mukherjee
Keyword(s):  
Transition Metal ◽  
Organic Solvents ◽  
Aqueous Media ◽  
Cross Coupling ◽  
Transition Metal Catalysts ◽  
Synthetic Methods ◽  
Coupling Reactions ◽  
Organic Transformations ◽  
Green Approach ◽  
Dehydrogenative Coupling

Abstract: A natural driving force is always working behind the synthetic organic chemists towards the development of ‘green’ synthetic methodologies for the synthesis of useful classes of organic molecules having potential applications. The majority of the essential classes of organic transformations, including C-C and C-X (X = heteroatom) bond-forming crosscoupling reactions, cross dehydrogenative-coupling (CDC) mostly rely on the requirement of transition-metal catalysts and hazardous organic solvents. Hence, the scope in developing green synthetic strategies by avoiding the use of transitionmetal catalysts and hazardous organic solvents for those important and useful classes of organic transformations is very high. Hence, several attempts are made so far. Water being the most abundant, cheap, and green solvent in the world; numerous synthetic methods have been developed in an aqueous medium. In this review, the development of transitionmetal- free green synthetic strategies for various important classes of organic transformations such as C-C and C-X bondforming cross-coupling, cross dehydrogenative-coupling, and oxidative-coupling in an aqueous media is discussed.

scholarly journals Manganese-catalyzed selective C–H activation and deuteration by means of a catalytic transient directing group strategy

2021 ◽  
Author(s):  
Sara Kopf ◽  
Helfried Neumann ◽  
Matthias Beller
Keyword(s):  
Group Strategy ◽  
One Step ◽  
Directing Group

A shortcut to ortho-deuterated aldehydes: a catalytic directing group enables the manganese-catalyzed C–H activation and deuteration of benzaldehydes in one step.

A Transient Directing Group Strategy Enables Enantioselective Multicomponent Organofluorine Synthesis

2021 ◽  
Author(s):  
Zhonglin Liu ◽  
Lucas J. Oxtoby ◽  
Mingyu Liu ◽  
Zi-Qi Li ◽  
Van T. Tran ◽  
...  
Keyword(s):  
Group Strategy ◽  
Directing Group

Directing Group Participated Benzylic C(sp3)–H/C(sp2)–H Cross-Dehydrogenative Coupling (CDC): Synthesis of Azapolycycles

2018 ◽  
Vol 20 (3) ◽  
pp. 652-655 ◽  
Author(s):  
Yaojia Jiang ◽  
Gongtao Deng ◽  
Shuaishuai Zhang ◽  
Teck-Peng Loh
Keyword(s):  
Dehydrogenative Coupling ◽  
Directing Group

Synthesis of Functionalized Triphenylenes via a Traceless Directing Group Strategy

2018 ◽  
Vol 20 (6) ◽  
pp. 1491-1495 ◽  
Author(s):  
Shuai Yang ◽  
Feng Wang ◽  
Yanqi Wu ◽  
Wenkai Hua ◽  
Fengzhi Zhang
Keyword(s):  
Group Strategy ◽  
Directing Group

scholarly journals A Transient‐Directing‐Group Strategy Enables Enantioselective Reductive Heck Hydroarylation of Alkenes

2020 ◽  
Vol 59 (23) ◽  
pp. 8885-8890 ◽  
Author(s):  
Lucas J. Oxtoby ◽  
Zi‐Qi Li ◽  
Van T. Tran ◽  
Tuğçe G. Erbay ◽  
Ruohan Deng ◽  
...  
Keyword(s):  
Group Strategy ◽  
Directing Group
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