Enantioselective formal synthesis of the marine macrolide (−)-callyspongiolide

2020 ◽  
Vol 56 (41) ◽  
pp. 5536-5539
Author(s):  
Aina Urbina ◽  
Núria Llor ◽  
Maria Vittoria Barbieri ◽  
Joan Bosch ◽  
Mercedes Amat
Keyword(s):  
Formal Synthesis ◽  
Cytotoxic Macrolide

An enantioselective formal synthesis of the cytotoxic macrolide (−)-callyspongiolide, in eight steps from aldehyde 4, is reported.

Microwave-assisted Iodine-catalyzed Rapid Synthesis of 6H-indolo[2,3-b] quinolines: Formal Synthesis of Cryptotackieine

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Prakash T. Parvatkar ◽  
Perunninakulath S. Parameswaran ◽  
Debasish Bandyopadhyay ◽  
Sanghamitra Mukherjee ◽  
Bimal K. Banik
Keyword(s):  
Rapid Synthesis ◽  
Formal Synthesis ◽  
Microwave Assisted

Diastereoselective Formal Synthesis of Polycyclic Meroterpenoid (±)-Cochlearol A

2021 ◽  
Author(s):  
Telugu Venkatesh ◽  
Prathama S. Mainkar ◽  
Srivari Chandrasekhar
Keyword(s):  
Formal Synthesis

A Formal Synthesis of a Muscarinic M1 Receptor Antagonist, (-)-TAN1251A

Heterocycles ◽  
2004 ◽  
Vol 62 (1) ◽  
pp. 343 ◽  
Author(s):  
Toshio Honda ◽  
Hirotake Mizutani ◽  
Jun Takayama ◽  
Yukio Soeda
Keyword(s):  
Receptor Antagonist ◽  
Formal Synthesis ◽  
M1 Receptor

Scope of Stereoselective Mn-Mediated Radical Addition to Chiral Hydrazones and Application in a Formal Synthesis of Quinine

2012 ◽  
Vol 77 (7) ◽  
pp. 3159-3180 ◽  
Author(s):  
Gregory K. Friestad ◽  
An Ji ◽  
Jonas Baltrusaitis ◽  
Chandra Sekhar Korapala ◽  
Jun Qin
Keyword(s):  
Radical Addition ◽  
Formal Synthesis

Optimization of Protoplast Formation, Regeneration, and Viability in Sorangium cellulosum

2020 ◽  
Vol 861 ◽  
pp. 303-308
Author(s):  
Guo Li Gong ◽  
Zhi Qiang Liu
Keyword(s):  
Secondary Metabolites ◽  
Drug Development ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Genome Shuffling ◽  
Protoplast Formation ◽  
Sorangium Cellulosum ◽  
Factors Affecting ◽  
Microtubule Stabilization ◽  
Cytotoxic Macrolide

Sorangium cellulosum can product many secondary metabolites that is unique structural and makes these microorganisms highly attractive for drug development, especially epothilone, on cancer cells a cytotoxic macrolide which is naturally produced by Soxhlet cellulose that have the action of microtubule stabilization, is a promising anticancer drug. In this research, the factors affecting the regeneration and preparation of the protoplast of Sorangium cellulosum were discussed, those were regeneration media, enzymes and osmotic stabilizers. This study provide the distruction for improving the production of epothilone through genome shuffling, mutation, fusion and transformation.

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