Boosting the abscopal effect of radiotherapy: a smart antigen-capturing radiosensitizer to eradicate metastatic breast tumors

2020 ◽  
Vol 56 (71) ◽  
pp. 10353-10356
Author(s):  
Yuanyuan Chen ◽  
Wei Pan ◽  
Peng Gao ◽  
Mingwan Shi ◽  
Tong Wu ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Breast Tumors ◽  
Abscopal Effect ◽  
Tumor Treatment ◽  
Mesoporous Titanium Dioxide ◽  
Metastatic Breast Tumor

A smart antigen-capturing radiosensitizer based on hollow mesoporous titanium dioxide (HTiO2) has been developed for metastatic breast tumor treatment.

scholarly journals Biochemical and Anti-Triple Negative Metastatic Breast Tumor Cell Properties of Psammaplins

Marine Drugs ◽  
2018 ◽  
Vol 16 (11) ◽  
pp. 442 ◽  
Author(s):  
Yu-Dong Zhou ◽  
Jun Li ◽  
Lin Du ◽  
Fakhri Mahdi ◽  
Thuy Le ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Breast Tumor ◽  
Triple Negative ◽  
Hdac Inhibitors ◽  
Metastatic Breast ◽  
Dependent Manner ◽  
Breast Tumor Cells ◽  
Metastatic Breast Tumor

Breast tumors reprogram their cellular metabolism, nutrient uptake, and utilization-associated biochemical processes. These processes become further transformed as genetically predisposed metastatic breast tumor cells colonize specific organs. Breast tumor cells often metastasize to the brain, bone, lung and liver. Massagué and colleagues isolated organotropic subclones and established organ-specific gene signatures associated with lung-, bone-, and brain-specific metastatic triple-negative breast cancer (TNBC) MDA-MB-231 cells. Using these genetically characterized metastatic subclones specific to lung (LM4175), bone (BoM1833), and brain (BrM-2a), we evaluated marine natural products for the ability to differentially suppress metastatic breast cancer cells in a target organ-dependent manner. Psammaplin-based histone deacetylase (HDAC) inhibitors were found to differentially inhibit HDAC activity, induce activation of hypoxia-inducible factor-1 (HIF-1), and disrupt organotropic metastatic TNBC subclone growth. Further, psammaplins distinctly suppressed the outgrowth of BoM1833 tumor spheroids in 3D-culture systems. Similar results were observed with the prototypical HDAC inhibitor trichostatin A (TSA). These organotropic tumor cell-based studies suggest the potential application of HDAC inhibitors that may yield new directions for anti-metastatic breast tumor research and drug discovery.

scholarly journals A Case of Metastatic Breast Tumor from Ovarian Cancer with Suspicious Breast Calcification

2017 ◽  
Vol 78 (9) ◽  
pp. 1999-2004 ◽  
Author(s):  
Ayana IKARI ◽  
Satoru TANAKA ◽  
Toshikatsu NITTA ◽  
Hiroyuki TANISHIMA ◽  
Tetsuya HORIUCHI ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Breast Calcification ◽  
Metastatic Breast Tumor

scholarly journals Monocytes mediate metastatic breast tumor cell adhesion to endothelium under flow

2013 ◽  
Vol 27 (8) ◽  
pp. 3017-3029 ◽  
Author(s):  
Shankar J. Evani ◽  
Rajesh G. Prabhu ◽  
V. Gnanaruban ◽  
Ender A. Finol ◽  
Anand K. Ramasubramanian
Keyword(s):  
Cell Adhesion ◽  
Tumor Cell ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Breast Tumor Cell ◽  
Tumor Cell Adhesion ◽  
Metastatic Breast Tumor

scholarly journals The diagnosis of a metastatic breast tumor from ovarian cancer by the succession of a p53 mutation: a case report

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Ryutaro Mori ◽  
Manabu Futamura ◽  
Kasumi Morimitsu ◽  
Chiemi Saigo ◽  
Tatsuhiko Miyazaki ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Case Report ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
P53 Mutation ◽  
Metastatic Breast Tumor

Medullary compression secondary to a metastatic breast tumor

The Breast ◽  
2017 ◽  
Vol 32 ◽  
pp. S68
Author(s):  
H. Ouahbi ◽  
F.Z. El’emrabet ◽  
L. Amaadour ◽  
M. Benhami ◽  
Z. Benbrahim ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Metastatic Breast ◽  
Metastatic Breast Tumor

Protective effects of dendrosomal curcumin on an animal metastatic breast tumor

2015 ◽  
Vol 758 ◽  
pp. 188-196 ◽  
Author(s):  
Baharak Farhangi ◽  
Ali Mohammad Alizadeh ◽  
Hamid Khodayari ◽  
Saeed Khodayari ◽  
Mohammad Javad Dehghan ◽  
...  
Keyword(s):  
Breast Tumor ◽  
Metastatic Breast ◽  
Protective Effects ◽  
Metastatic Breast Tumor

Lack of Telopeptides in Fibrillar Collagen I Promotes the Invasion of a Metastatic Breast Tumor Cell Line

2005 ◽  
Vol 65 (13) ◽  
pp. 5674-5682 ◽  
Author(s):  
Zoe N. Demou ◽  
Michael Awad ◽  
Trevor McKee ◽  
Jean Yannis Perentes ◽  
Xiaoye Wang ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Line ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Tumor Cell Line ◽  
Collagen I ◽  
Fibrillar Collagen ◽  
Breast Tumor Cell ◽  
Breast Tumor Cell Line ◽  
Metastatic Breast Tumor
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