Inhibition of 3D colon cancer stem cell spheroids by cytotoxic RuII-p-cymene complexes of mesalazine derivatives

2020 ◽  
Vol 56 (40) ◽  
pp. 5421-5424
Author(s):  
Sourav Acharya ◽  
Subhashis Ghosh ◽  
Moumita Maji ◽  
Ajmal Roshan Unniram Parambil ◽  
Sandeep Singh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Cell Spheroids ◽  
Colon Cancer Stem Cell

RuII-p-cymene complexes of imidazole–mesalazine based ligands kill bulk and stem colon cancer cells with tight regulation over stemness markers.

Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture

2018 ◽  
Vol 375 (3) ◽  
pp. 697-707 ◽  
Author(s):  
Kanji Hirashima ◽  
Fengming Yue ◽  
Mikiko Kobayashi ◽  
Yuriko Uchida ◽  
Shunsuke Nakamura ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals Induction of Cancer Stem Cell Properties in Colon Cancer Cells by Defined Factors

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e101735 ◽  
Author(s):  
Nobu Oshima ◽  
Yasuhiro Yamada ◽  
Satoshi Nagayama ◽  
Kenji Kawada ◽  
Suguru Hasegawa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Colon Cancer Cells

CXCL2/CXCR2 axis induces cancer stem cell characteristics in CPT‐11‐resistant LoVo colon cancer cells via Gαi‐2 and Gαq/11

2018 ◽  
Vol 234 (7) ◽  
pp. 11822-11834 ◽  
Author(s):  
Ming‐Cheng Chen ◽  
Rathinasamy Baskaran ◽  
Nien‐Hung Lee ◽  
Hsi‐Hsien Hsu ◽  
Tsung‐Jung Ho ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Colon Cancer Cells

scholarly journals MicroRNA-377 Counteracts With Cancer Stem Cell Phenotypes and Epithelial Mesenchymal Transformation by Targeting ZEB2 in Colon Cancer

2020 ◽  
Vol 19 ◽  
pp. 153303382096747
Author(s):  
Paerhati Shayimu ◽  
Aikeremu Yusufu ◽  
Aizimaiti Rehemutula ◽  
Darebai Redati ◽  
Rexida Jiapaer ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Mesenchymal Transition ◽  
Over Expression ◽  
Mesenchymal Transformation ◽  
Cell Phenotypes ◽  
Sphere Formation

Dysregulated microRNAs (miRNAs) have been implicated in the pathogenic processes of colon cancer. Epithelial mesenchymal transition (EMT) promotes metastatic progression and cancer stem cells are closely involved in colon cancer proliferation and metastasis. Functional effects of miR-377 on colon cancer stem cell phenotypes and EMT were then determined in the present study. Firstly, reduced miR-377 was found in colon cancer tissues and cell lines. Results from flow cytometry, sphere formation and western blot assays showed that miR-377 knockdown increased number of ALDH+ cells and promoted sphere formation ability. Moreover, cell migration/invasion and EMT of colon cancer cells were suppressed by miR-377 over-expression. On the contrary, miR-377 mimics caused the reversed results. ZEB2 (zinc finger E box-binding homeobox 2) was then validated as a binding target of miR-377. ZEB2 over-expression reversed the inhibitory abilities of miR-377 on cancer stem cell phenotypes, EMT, migration and invasion. In conclusion, miR-377 regulates cancer stem cell phenotypes and EMT in colon cancer cells via regulation of ZEB2, suggesting a new therapeutic strategy for colon cancer treatment.

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