Using changes in speciation in a dynamic combinatorial library as a fingerprint to differentiate the methylation states of arginine

2020 ◽  
Vol 56 (28) ◽  
pp. 3947-3950
Author(s):  
Alexandria G. Mullins ◽  
Lauren E. St. Louis ◽  
Marcey L. Waters
Keyword(s):  
Combinatorial Library ◽  
Sensor Array ◽  
Direct Method ◽  
Dynamic Combinatorial Library ◽  
A Direct Method

A dynamic combinatorial library was shown to provide a direct method of sensing methylated arginine and lysine due to differences in speciation. This provides the first sensor array for all the methylation states of arginine.

scholarly journals Plastic waste to fuels by hydrocracking at mild conditions

2021 ◽  
Vol 7 (17) ◽  
pp. eabf8283
Author(s):  
Sibao Liu ◽  
Pavel A. Kots ◽  
Brandon C. Vance ◽  
Andrew Danielson ◽  
Dionisios G. Vlachos
Keyword(s):  
Direct Method ◽  
Acid Sites ◽  
Liquid Fuels ◽  
High Yield ◽  
Tandem Catalysis ◽  
Hy Zeolite ◽  
Environmental Threat ◽  
Single Use ◽  
Initial Activation ◽  
A Direct Method

Single-use plastics impose an enormous environmental threat, but their recycling, especially of polyolefins, has been proven challenging. We report a direct method to selectively convert polyolefins to branched, liquid fuels including diesel, jet, and gasoline-range hydrocarbons, with high yield up to 85% over Pt/WO3/ZrO2 and HY zeolite in hydrogen at temperatures as low as 225°C. The process proceeds via tandem catalysis with initial activation of the polymer primarily over Pt, with subsequent cracking over the acid sites of WO3/ZrO2 and HY zeolite, isomerization over WO3/ZrO2 sites, and hydrogenation of olefin intermediates over Pt. The process can be tuned to convert different common plastic wastes, including low- and high-density polyethylene, polypropylene, polystyrene, everyday polyethylene bottles and bags, and composite plastics to desirable fuels and light lubricants.

scholarly journals π-Stacking Stopper-Macrocycle Stabilized Dynamically Interlocked [2]Rotaxanes

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4704
Author(s):  
Sing-Ming Chan ◽  
Fung-Kit Tang ◽  
Ching-Yau Lam ◽  
Chak-Shing Kwan ◽  
Sam C. K. Hau ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Thermodynamic Stability ◽  
Combinatorial Library ◽  
Aromatic Rings ◽  
Interlocked Molecules ◽  
X Ray ◽  
Π Stacking ◽  
Dynamic Combinatorial Library

The synthesis of mechanically interlocked molecules is valuable due to their unique topologies. With π-stacking intercomponent interaction, e.g., phenanthroline and anthracene, novel [2]rotaxanes have been synthesized by dynamic imine clipping reaction. Their X-ray crystal structures indicate the π-stackings between the anthracene moiety (stopper) on the thread and the (hetero)aromatic rings at the macrocycle of the rotaxanes. Moreover, the length of glycol chains affects the extra π-stacking intercomponent interactions between the phenyl groups and the dimethoxy phenyl groups on the thread. Dynamic combinatorial library has shown at best 84% distribution of anthracene-threaded phenanthroline-based rotaxane, coinciding with the crystallography in that the additional π-stacking intercomponent interactions could increase the thermodynamic stability and selectivity of the rotaxanes.

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