Molecular engineering to boost the photothermal effect of conjugated oligomer nanoparticles

2021 ◽  
Author(s):  
Hui Zhang ◽  
Lixia Guo ◽  
Yunxia Wang ◽  
Liheng Feng
Keyword(s):  
Antibacterial Therapy ◽  
Molecular Engineering ◽  
Photothermal Effect ◽  
Conjugated Molecules ◽  
Ethynyl Group ◽  
Engineering Strategy

A novel molecular engineering strategy to enhance the photothermal performance of conjugated molecules was developed by introducing the ethynyl group into the structure for effective antibacterial therapy.

Molecular engineering of twisted dipolar chromophores for efficiency boosted BHJ solar cells

2021 ◽  
Author(s):  
Abbasriyaludeen Abdul Raheem ◽  
Chitra Kumar ◽  
Ramasamy Shanmugam ◽  
P. Murugan ◽  
Praveen Chandrasekar
Keyword(s):  
Solar Cells ◽  
Molecular Engineering ◽  
Engineering Strategy

Herein, we disclose the synthesis of new D-π-A push-pull chromophores (10 examples; 2a-2j) by tethering tetracyanoquinodimethane (TCNQ) as auxiliary group instead of previously reported tetracyanoethylene (TCNE). This molecular engineering strategy...

scholarly journals A design strategy for high mobility stretchable polymer semiconductors

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jaewan Mun ◽  
Yuto Ochiai ◽  
Weichen Wang ◽  
Yu Zheng ◽  
Yu-Qing Zheng ◽  
...  
Keyword(s):  
Conjugated Polymers ◽  
Molecular Design ◽  
High Mobility ◽  
Molecular Engineering ◽  
Semiconducting Polymers ◽  
Stretchable Electronics ◽  
General Applicability ◽  
Multi Scale ◽  
Polymer Semiconductors ◽  
Engineering Strategy

AbstractAs a key component in stretchable electronics, semiconducting polymers have been widely studied. However, it remains challenging to achieve stretchable semiconducting polymers with high mobility and mechanical reversibility against repeated mechanical stress. Here, we report a simple and universal strategy to realize intrinsically stretchable semiconducting polymers with controlled multi-scale ordering to address this challenge. Specifically, incorporating two types of randomly distributed co-monomer units reduces overall crystallinity and longer-range orders while maintaining short-range ordered aggregates. The resulting polymers maintain high mobility while having much improved stretchability and mechanical reversibility compared with the regular polymer structure with only one type of co-monomer units. Interestingly, the crystalline microstructures are mostly retained even under strain, which may contribute to the improved robustness of our stretchable semiconductors. The proposed molecular design concept is observed to improve the mechanical properties of various p- and n-type conjugated polymers, thus showing the general applicability of our approach. Finally, fully stretchable transistors fabricated with our newly designed stretchable semiconductors exhibit the highest and most stable mobility retention capability under repeated strains of 1,000 cycles. Our general molecular engineering strategy offers a rapid way to develop high mobility stretchable semiconducting polymers.

scholarly journals Design of a new effector recognition specificity in a plant NLR immune receptor by molecular engineering of its integrated decoy domain

2021 ◽  
Author(s):  
Stella Cesari ◽  
Yuxuan Xi ◽  
Nathalie Declerck ◽  
Véronique Chalvon ◽  
Léa Mammri ◽  
...  
Keyword(s):  
Immune Responses ◽  
Crop Protection ◽  
Molecular Engineering ◽  
Future Research ◽  
Pathogen Effectors ◽  
Recognition Specificity ◽  
Heterologous System ◽  
Binding Surface ◽  
Engineering Strategy ◽  
Effector Recognition

SUMMARYPlant nucleotide-binding and leucine-rich repeat domain proteins (NLRs) are immune sensors that specifically recognize pathogen effectors and induce immune responses. Designing artificial NLRs with new effector recognition specificities is a promising prospect for sustainable, knowledge-driven crop protection. However, such strategies are hampered by the complexity of NLR function. Here, we tested whether molecular engineering of the integrated decoy domain (ID) of an NLR could extend its recognition spectrum to a new effector. To this aim, we relied on the detailed molecular knowledge of the recognition of distinct Magnaporthe oryzae MAX (Magnaporthe AVRs and ToxB-like) effectors by the rice NLRs RGA5 and Pikp-1. For both NLRs, effector recognition involves physical binding to their HMA (Heavy Metal-Associated) IDs. However, AVR-PikD, the effector recognized by Pikp-1, binds to a completely different surface of the HMA domain compared to AVR-Pia and AVR1-CO39, recognized by RGA5. By introducing into the HMA domain of RGA5 the residues of the Pikp-1 HMA domain involved in AVR-PikD binding, we created a high-affinity binding surface for this new effector. In the Nicotiana benthamiana heterologous system, RGA5 variants carrying this engineered binding surface still recognize AVR-Pia and AVR1-CO39, but also perceive the new ligand, AVR-PikD, resulting in the activation of immune responses. Therefore, our study provides a proof of concept for the design of new effector recognition specificities in NLRs through molecular engineering of IDs. However, it pinpoints significant knowledge gaps that limit the full deployment of this NLR-ID engineering strategy and provides hypotheses for future research on this topic.

CsPbBr3 quantum dots photodetectors boosting carrier transport via molecular engineering strategy

Nano Research ◽  
2021 ◽  
Author(s):  
Wei Yan ◽  
Jianhua Shen ◽  
Yihua Zhu ◽  
Yiqing Gong ◽  
Jingrun Zhu ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Carrier Transport ◽  
Molecular Engineering ◽  
Engineering Strategy ◽  
Cspbbr3 Quantum Dots

Fluorescence ratio imaging of dynamic intracellular ionic signals

1988 ◽  
Vol 46 ◽  
pp. 42-43
Author(s):  
R. Y. Tsien ◽  
A. Minta ◽  
M. Poenie ◽  
J.P.Y. Kao ◽  
A. Harootunian
Keyword(s):  
Binding Sites ◽  
Living Cells ◽  
Molecular Engineering ◽  
Ph Indicators ◽  
Highly Sensitive ◽  
Fluorescence Ratio Imaging ◽  
Ratio Imaging ◽  
Technical Advances ◽  
Indicator Dyes ◽  
Fluorescein Dyes

Recent technical advances now enable the continuous imaging of important ionic signals inside individual living cells with micron spatial resolution and subsecond time resolution. This methodology relies on the molecular engineering of indicator dyes whose fluorescence is strong and highly sensitive to ions such as Ca2+, H+, or Na+, or Mg2+. The Ca2+ indicators, exemplified by fura-2 and indo-1, derive their high affinity (Kd near 200 nM) and selectivity for Ca2+ to a versatile tetracarboxylate binding site3 modeled on and isosteric with the well known chelator EGTA. The most commonly used pH indicators are fluorescein dyes (such as BCECF) modified to adjust their pKa's and improve their retention inside cells. Na+ indicators are crown ethers with cavity sizes chosen to select Na+ over K+: Mg2+ indicators use tricarboxylate binding sites truncated from those of the Ca2+ chelators, resulting in a more compact arrangement of carboxylates to suit the smaller ion.

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