Regeneration of irradiation-damaged esophagus by local delivery of mesenchymal stem-cell spheroids encapsulated in a hyaluronic-acid-based hydrogel

2021 ◽  
Author(s):  
In Gul Kim ◽  
Hana Cho ◽  
Jisoo Shin ◽  
Jung Ho Cho ◽  
Seung-Woo Cho ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
Mesenchymal Stem Cell ◽  
Local Delivery ◽  
Cell Spheroids ◽  
Radiation Induced

This article presented the efficacy of hyaluronic acid (HA)-gel-encapsulated mesenchymal stem cell spheroids (MSC-SPs) for ultimate treatment of radiation-induced esophageal fibrosis.

scholarly journals Mesenchymal Stem Cell-Derived Exosomes: Biological Function and Their Therapeutic Potential in Radiation Damage

Cells ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Xiaoyu Pu ◽  
Siyang Ma ◽  
Yan Gao ◽  
Tiankai Xu ◽  
Pengyu Chang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Radiation Damage ◽  
Therapeutic Potential ◽  
Damage Model ◽  
Bioactive Substances ◽  
Radiation Induced ◽  
Insight Into

Radiation-induced damage is a common occurrence in cancer patients who undergo radiotherapy. In this setting, radiation-induced damage can be refractory because the regeneration responses of injured tissues or organs are not well stimulated. Mesenchymal stem cells have become ideal candidates for managing radiation-induced damage. Moreover, accumulating evidence suggests that exosomes derived from mesenchymal stem cells have a similar effect on repairing tissue damage mainly because these exosomes carry various bioactive substances, such as miRNAs, proteins and lipids, which can affect immunomodulation, angiogenesis, and cell survival and proliferation. Although the mechanisms by which mesenchymal stem cell-derived exosomes repair radiation damage have not been fully elucidated, we intend to translate their biological features into a radiation damage model and aim to provide new insight into the management of radiation damage.

scholarly journals Repeated Autologous Bone Marrow-Derived Mesenchymal Stem Cell Injections Improve Radiation-Induced Proctitis in Pigs

2013 ◽  
Vol 2 (11) ◽  
pp. 916-927 ◽  
Author(s):  
Christine Linard ◽  
Elodie Busson ◽  
Valerie Holler ◽  
Carine Strup-Perrot ◽  
Jean-Victor Lacave-Lapalun ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Autologous Bone Marrow ◽  
Radiation Induced ◽  
Autologous Bone

Scalable and cost-effective generation of osteogenic micro-tissues through the incorporation of inorganic microparticles within mesenchymal stem cell spheroids

2019 ◽  
Vol 12 (1) ◽  
pp. 015021 ◽  
Author(s):  
Ibrahim Zarkesh ◽  
Majid Halvaei ◽  
Mohammad Hossein Ghanian ◽  
Fatemeh Bagheri ◽  
Forough Azam Sayahpour ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cost Effective ◽  
Cell Spheroids ◽  
Effective Generation

Mesenchymal Stem Cell Spheroids Embedded in an Injectable Thermosensitive Hydrogel: An In Situ Drug Formation Platform for Accelerated Wound Healing

2020 ◽  
Vol 6 (9) ◽  
pp. 5096-5109
Author(s):  
Mohammad Ali Nilforoushzadeh ◽  
Mohsen Khodadadi Yazdi ◽  
Shaghayegh Baradaran Ghavami ◽  
Samila Farokhimanesh ◽  
Leila Mohammadi Amirabad ◽  
...  
Keyword(s):  
Wound Healing ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Thermosensitive Hydrogel ◽  
Cell Spheroids

scholarly journals Donor Variation and Optimization of Human Mesenchymal Stem Cell Chondrogenesis in Hyaluronic Acid

2018 ◽  
Vol 24 (21-22) ◽  
pp. 1693-1703 ◽  
Author(s):  
Minwook Kim ◽  
Isaac E. Erickson ◽  
Alice H. Huang ◽  
Sean T. Garrity ◽  
Robert L. Mauck ◽  
...  
Keyword(s):  
Stem Cell ◽  
Hyaluronic Acid ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Donor Variation
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