An ROS-sensitive tegafur-PpIX-heterodimer-loaded in situ injectable thermosensitive hydrogel for photodynamic therapy combined with chemotherapy to enhance the tegafur-based treatment of breast cancer

2021 ◽  
Vol 9 (1) ◽  
pp. 221-237
Author(s):  
Zhiqiang Zhang ◽  
Anning Li ◽  
Xingqi Min ◽  
Qunqun Zhang ◽  
Jun Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Protoporphyrin Ix ◽  
Temperature Sensitive ◽  
Thermosensitive Hydrogel ◽  
Temperature Sensitive Hydrogel

A temperature-sensitive hydrogel encapsulating tegafur and protoporphyrin IX dimers could be delivered intratumorally for synergetic chemotherapy and photodynamic therapy.

scholarly journals Biodegradable Silica‐Based Nanoparticles with Improved and Safe Delivery of Protoporphyrin IX for the In Vivo Photodynamic Therapy of Breast Cancer

2020 ◽  
Vol 3 (7) ◽  
pp. 2000022 ◽  
Author(s):  
Zachary K. Lyles ◽  
Mubin Tarannum ◽  
Cayli Mena ◽  
Natalia M. Inada ◽  
Vanderlei S. Bagnato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Protoporphyrin Ix ◽  
Safe Delivery

Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology

Nanomedicine ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. 1019-1036
Author(s):  
Laise R de Andrade ◽  
Antonio C Tedesco ◽  
Fernando L Primo ◽  
Gabriel R Farias ◽  
Jaqueline R da Silva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Tumor Progression ◽  
Intervention Strategy ◽  
Protoporphyrin Ix ◽  
Drug Candidate ◽  
Tumor Control ◽  
Tumor Cell Death ◽  
Long Term Effect ◽  
Primary Mammary Tumor

Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.

UCPs/Zn2GeO4:Mn2+/g-C3N4 heterojunction engineered injectable thermosensitive hydrogel for oxygen independent breast cancer neoadjuvant photodynamic therapy

2021 ◽  
Author(s):  
Linchao Zhang ◽  
Manli Yang ◽  
Yishun Ji ◽  
Kefeng Xiao ◽  
Jinsheng Shi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Breast Conservation ◽  
Thermosensitive Hydrogel ◽  
Large Tumor ◽  
Tumor Mass

Neoadjuvant chemotherapy for the treatment of breast cancer can provide the option of surgery for patients with a large tumor mass or increase the rate of breast conservation.

scholarly journals Fast-responsive temperature-sensitive hydrogels

BioResources ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. 8543-8558
Author(s):  
Xiaohui Wang ◽  
Qingqing Dai ◽  
Haoquan Zhong ◽  
Xinxin Liu ◽  
Junli Ren
Keyword(s):  
Near Infrared ◽  
Reaction Medium ◽  
Solution Temperature ◽  
Temperature Sensitive ◽  
Thermosensitive Hydrogel ◽  
Hydrogel Matrix ◽  
Hydrophilic Monomer ◽  
Responsive Behavior ◽  
Carboxymethyl Xylan

Temperature fast-responsive and magnetic poly(N-isopropylacrylamide-co-acrylamide) (CMX-MNP-PNIPAm/Fe3O4) hydrogels were developed using carboxymethyl xylan (CMX) as a pore-forming agent and a NaCl solution as the reaction medium, followed by fabricating Fe3O4 nanoparticles in situ within the hydrogel matrix. It was found that NaCl played a role in the phase separation and was used as the electrolyte to shield CMX molecular chains. The obtained hydrogels exhibited a fast, temperature-responsive behavior, and the water retention was less than 15% for 1 min under 60 °C. The prepared hydrogels showed enhanced mechanical properties and magnetic properties due to the presence of Fe3O4 particles. The lower critical solution temperature of the hydrogels was in the range of 35 to 39 °C, which was acquired through adjusting the amount of hydrophilic monomer (AM). The magnetic and thermosensitive hydrogel had the attractive photothermal conversion ability and could be heated to 40 °C within 2 min, and to 69 °C within 7 min under near infrared irradiation.

scholarly journals Photodynamic Therapy Induced Cell Death Mechanisms in Breast Cancer

2021 ◽  
Vol 22 (19) ◽  
pp. 10506
Author(s):  
Dimakatso R. Mokoena ◽  
Blassan P. George ◽  
Heidi Abrahamse
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Cell ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Normal Cells ◽  
Cell Death Mechanisms

Breast cancer is the second most common cancer globally and the pioneering cause of mortality among women. It usually begins from the ducts or lobules, referred to as ductal carcinoma in situ, or lobular carcinoma in situ. Age, mutations in Breast Cancer Gene 1 or 2 (BRCA1 or BRCA2) genes, and dense breast tissue are the highest risk factors. Current treatments are associated with various side effects, relapse, and a low quality of life. Although conventional treatments, such as surgery and chemotherapy, have been used for decades, their adverse side effects on normal cells and tissues pose a major weakness, which calls for a non-invasive treatment option. Photodynamic therapy (PDT) has proven to be a promising form of cancer therapy. It is less invasive, target-specific, and with reduced cytotoxicity to normal cells and tissues. It involves the use of a photosensitizer (PS) and light at a specific wavelength to produce reactive oxygen species. One of the reasons for the target specificity is associated with the dense vascularization of cancer tissues, which tends to increase the surface area for the PS uptake. Photosensitizers are light-sensitive molecules, which result in cancer cell destruction followed by light irradiation. Depending on the localization of the PS within the cancer cell, its destruction may be via apoptosis, necrosis, or autophagy. This review focuses on the breast cancer etiopathology and PDT-induced cell death mechanisms in breast cancer cells.

Intra-articular injection of indomethacin–methotrexate in situ hydrogel for the synergistic treatment of rheumatoid arthritis

2020 ◽  
Vol 8 (5) ◽  
pp. 993-1007 ◽  
Author(s):  
Na Yin ◽  
Xueting Guo ◽  
Rong Sun ◽  
Hongbing Liu ◽  
Lihua Tang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Temperature Sensitive ◽  
In Situ Hydrogel ◽  
Temperature Sensitive Hydrogel

Intra-articular injection of a temperature-sensitive hydrogel containing D-NPs formed by PEI-SS and IND and MTX.

scholarly journals Targeted Photodynamic Therapy Using Alloyed Nanoparticle-Conjugated 5-Aminolevulinic Acid for Breast Cancer

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1375
Author(s):  
Hanieh Montaseri ◽  
Cherie Ann Kruger ◽  
Heidi Abrahamse
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Electrostatic Interactions ◽  
Breast Cancer Cells ◽  
Bimetallic Nanoparticles ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Mcf 7

Photodynamic therapy (PDT) has been investigated as an effective, non-invasive, and alternative tumor-ablative therapy that uses photosensitizers (PSs) and safe irradiation light in the presence of oxygen to generate reactive oxygen species (ROS) to kill malignant cancer cells. However, the off-target activation of the PSs can hinder effective PDT. Therefore, an advanced drug delivery system is required to selectively deliver the PS to the therapeutic region only and reduce off-target side effects in cancer treatment. The integration of laser-initiated PDT with nanotechnology has provided new opportunities in cancer therapy. In this study, plasmonic bimetallic nanoparticles (NPs) were prepared for the targeted PDT (TPDT) of in vitro cultured MCF-7 breast cancer cells. The NPs were functionalized with PEG through Au–thiol linkage to enhance their biocompatibility and subsequently attached to the PS precursor 5-aminolevulinic acid via electrostatic interactions. In order to enhance specific targeting, anti-HER-2 antibodies (Ab) were decorated onto the surface of the nanoconjugate (NC) to fabricate a 5-ALA/Au–Ag-PEG-Ab NC. In vitro studies showed that the synthesized NC can enter MCF-7 cells and localize in the cytoplasm to metabolize 5-ALA to protoporphyrin IX (PpIX). Upon light irradiation, PpIX can efficiently produce ROS for the PDT treatment of MCF-7. Cellular viability studies showed a decrease from 49.8% ± 5.6 ** to 13.8% ± 2.0 *** for free 5-ALA versus the NC, respectively, under equivalent concentrations of the PS (0.5 mM, IC50). These results suggest that the active targeted NC platform has an improved PDT effect on MCF-7 breast cancer cells.

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