scholarly journals Engineering extracellular vesicles for cancer therapy: recent advances and challenges in clinical translation

2020 ◽  
Vol 8 (24) ◽  
pp. 6978-6991
Author(s):  
Sha Li ◽  
Jinliang Xu ◽  
Jun Qian ◽  
Xihui Gao
Keyword(s):  
Cancer Therapy ◽  
Clinical Application ◽  
Extracellular Vesicles ◽  
Clinical Translation ◽  
Recent Advances ◽  
Wide Clinical Application

Extracellular vesicles have shown great advantages in cancer therapy, but there are still huge challenges to be overcome to implement their wide clinical application.

scholarly journals The versatile roles and clinical implications of exosomal mRNAs and microRNAs in cancer

2020 ◽  
Vol 35 (2) ◽  
pp. 3-19 ◽  
Author(s):  
Shuli Tang ◽  
Siming Yu ◽  
Jianan Cheng ◽  
Yanqiao Zhang ◽  
Xiaoyi Huang
Keyword(s):  
Drug Resistance ◽  
Cancer Therapy ◽  
Clinical Application ◽  
Extracellular Vesicles ◽  
Intercellular Communication ◽  
Bioactive Molecules ◽  
Clinical Implications ◽  
Multivesicular Bodies ◽  
Apoptotic Bodies ◽  
Application Potential

Extracellular vesicles (EVs), which include exosomes, microvesicles, and apoptotic bodies, are nanosized structures that are secreted by various cells and act as important mediators in intercellular communication. Recent studies have shown that exosomes carrying bioactive molecules are generated from multivesicular bodies and are present in various body fluids. mRNAs and microRNAs (miRNAs) are encapsulated in exosomes and have been found to be involved in multiple pathophysiological processes. Here, we provide a review of tumor-associated exosomal mRNAs and miRNAs and their roles in metastasis and drug resistance. In particular, we emphasize their clinical application potential as diagnostic and prognostic biomarkers of cancer and in cancer therapy.

Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application

2020 ◽  
Vol 63 (20) ◽  
pp. 11368-11396 ◽  
Author(s):  
Xinrui Yuan ◽  
Hong Bu ◽  
Jinpei Zhou ◽  
Chao-Yie Yang ◽  
Huibin Zhang
Keyword(s):  
Cancer Therapy ◽  
Clinical Application ◽  
Current Development ◽  
Recent Advances

scholarly journals Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation

2018 ◽  
Vol 5 ◽  
Author(s):  
Cameron Keighron ◽  
Caomhán J. Lyons ◽  
Michael Creane ◽  
Timothy O'Brien ◽  
Aaron Liew
Keyword(s):  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Clinical Translation ◽  
Endothelial Progenitor ◽  
Recent Advances

scholarly journals Emerging biogenesis technologies of extracellular vesicles for tissue regenerative therapeutics

2021 ◽  
Vol 12 ◽  
pp. 204173142110190
Author(s):  
Jung-Hwan Lee ◽  
Ji-Young Yoon ◽  
Jun Hee Lee ◽  
Hae-Hyoung Lee ◽  
Jonathan C Knowles ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Chemical Treatment ◽  
Mass Production ◽  
Disease Status ◽  
Clinical Translation ◽  
Technological Advances ◽  
Tissue Healing ◽  
Bio Imaging ◽  
Key Issues ◽  
Treatment Application

Extracellular vesicles (EVs), including exosomes, carry the genetic packages of RNA, DNA, and proteins and are heavily involved in cell-cell communications and intracellular signalings. Therefore, EVs are spotlighted as therapeutic mediators for the treatment of injured and dysfunctional tissues as well as biomarkers for the detection of disease status and progress. Several key issues in EVs, including payload content and bioactivity, targeting and bio-imaging ability, and mass-production, need to be improved to enable effective therapeutics and clinical translation. For this, significant efforts have been made recently, including genetic modification, biomolecular and chemical treatment, application of physical/mechanical cues, and 3D cultures. Here we communicate those recent technological advances made mainly in the biogenesis process of EVs or at post-collection stages, which ultimately aimed to improve the therapeutic efficacy in tissue healing and disease curing and the possibility of clinical translation. This communication will help tissue engineers and biomaterial scientists design and produce EVs optimally for tissue regenerative therapeutics.

Recent advances in the development of metal-organic framework-based gas nanoplatforms for synergistic cancer therapy

2021 ◽  
Author(s):  
Yong Yao ◽  
Danni Jing ◽  
Jianan Zhang ◽  
Youyou Huang ◽  
Xiru Qin ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Therapeutic Efficacy ◽  
Metal Organic Framework ◽  
Research Field ◽  
Tumor Site ◽  
Recent Advances ◽  
Metal Organic ◽  
Organic Framework

Featuring high therapeutic efficacy, biocompatibility, and biosafety, gas therapy as a burgeoning and promising research field has attracted considerable attention in biomedicine. However, the lack of the tumor site accumulation...

scholarly journals Intercellular Transmission of Naked Viruses through Extracellular Vesicles: Focus on Polyomaviruses

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1086
Author(s):  
Francois Helle ◽  
Lynda Handala ◽  
Marine Bentz ◽  
Gilles Duverlie ◽  
Etienne Brochot
Keyword(s):  
Immune System ◽  
Extracellular Vesicles ◽  
Rna Viruses ◽  
Viral Transmission ◽  
Viral Fitness ◽  
Host Cells ◽  
Dna Viruses ◽  
Recent Advances ◽  
Viral Particles ◽  
Similar Strategy

Extracellular vesicles have recently emerged as a novel mode of viral transmission exploited by naked viruses to exit host cells through a nonlytic pathway. Extracellular vesicles can allow multiple viral particles to collectively traffic in and out of cells, thus enhancing the viral fitness and diversifying the transmission routes while evading the immune system. This has been shown for several RNA viruses that belong to the Picornaviridae, Hepeviridae, Reoviridae, and Caliciviridae families; however, recent studies also demonstrated that the BK and JC viruses, two DNA viruses that belong to the Polyomaviridae family, use a similar strategy. In this review, we provide an update on recent advances in understanding the mechanisms used by naked viruses to hijack extracellular vesicles, and we discuss the implications for the biology of polyomaviruses.

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