Construction of a hierarchical micro & nanoporous surface for loading genistein on the composite of polyetheretherketone/tantalum pentoxide possessing antibacterial activity and accelerated osteointegration

2021 ◽  
Vol 9 (1) ◽  
pp. 167-185
Author(s):  
Shiqi Mei ◽  
Fan Wang ◽  
Xinglong Hu ◽  
Kong Yang ◽  
Dong Xie ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Sustained Release ◽  
Tantalum Pentoxide ◽  
Cell Responses ◽  
Nanoporous Surface

SPNG with a micro & nanoporous surface, SO3H groups, and sustained release of GT exhibited antibacterial activity, cell responses, and accelerated osteointegration.

scholarly journals SYNTHESIS AND CHARACTERIZATION OF NOVEL SA-PA-LSA/C-30B/AG NANOCOMPOSITES FOR SWELLING, ANTIBACTERIAL, DRUG DELIVERY, AND ANTICANCER APPLICATIONS

2018 ◽  
Vol 11 (3) ◽  
pp. 229
Author(s):  
Nanjunda Reddy B H ◽  
Prdadipta Ranjan Rauta ◽  
Venkatalakshimi V ◽  
Swamy Sreenivasa
Keyword(s):  
Drug Delivery ◽  
Antibacterial Activity ◽  
Sustained Release ◽  
Polymerization Reaction ◽  
Antibacterial Drug ◽  
Hacat Cells ◽  
Swelling Properties ◽  
Hydrogel Matrix ◽  
Hydrogel Composites ◽  
Lignosulfonic Acid

 Objective: The main objective of this work was to formulate and evaluate Closite-30B/nanoAg filled hydrogel composites which are further intentended to be used for the study of drug delivery,antibacterial, and anticancer activityMethods: In this study, Cloisite-30B (C-30B) clay dispersed biopolymer sodium alginate (SA)-grafted-poly (acrylamide [AAm]-co-lignosulfonic acid) hydrogel composites were synthesized by free radical in situ polymerization reaction technique using SA, AAm, and lignosulfonic acid biopolymers in different proportions in combination. which are subjected to invitro drug delivery and Minimum inhibitory concentration(MIC) method for antibacterial activity study by using Streptococcus faecalis (S.faecalis) and Escherichia coli (E. coli)bacteria. The biocompatibility of the prepared gels were determined by standard protocol HaCaT-cells and MCF-7 cell lines further the prepared hydrogel composites were characterized for particle size,encapsulation efficiency,swelling properties,compatibility studies by FTIR etc.Results: The formulated hydrogels were characterized by X-ray diffraction (XRD) to analyze the particles size and crystallinity. The presence of functional groups and their chemical interaction with the drug, C-30B, and silver nanoparticles (AgNPs) were confirmed by the FTIR spectroscopy. Furthermore, the presence of AgNPs in the matrix was confirmed by ultraviolet/visible spectroscopy. Thermogravimetric analysis was performed to find out the thermal degradation, thermal stability, and the percentage of weight loss at various temperatures. Swelling studies revealed that C-30B and AgNPs induced composites exhibited higher swelling ratio than pure hydrogels. The hydrogels with C-30B/AgNPs displayed excellent antibacterial activity against both Gram-positive and Gram-negative bacteria. Further, these hydrogel composites were loaded with the drug paclitaxel (PT), and drug release study showed that the sustained release of the drug from C-30B/Ag hydrogel matrix compared to rest of other samples. Hydrogel composites were cytocompatible in nature (with HaCaT cells) and the cell viability decreased (with MCF-7cells) with the presence of lignosulfonic acid as well as C-30B and AgNPs in the samples as evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide to its insoluble formazan assay.Conclusion: The synthesized hydrogel composites were successfully characterized and eavaluated for sustained release of paclitaxel drug delivery at different pHs and temperatures and it is found that C30B/Ag filled composites exhibits contolled release of drug with higher rate, especially at lower pH (pH2) and higher temperature (37oC) and the same formulations which exhibits better anitbcterial and anticancer activity compared to the virgin samples So the prepared C30B/AgNPs hydrogels composites used in drug dlivery for the effective treatment of cancer and used against bacterias and cancerous cells.

A polymer scaffold with drug-sustained release and antibacterial activity

2019 ◽  
Vol 69 (6) ◽  
pp. 398-405 ◽  
Author(s):  
Ping Wu ◽  
Shi Hu ◽  
Qin Liang ◽  
Wang Guo ◽  
Yang Xia ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Sustained Release ◽  
Polymer Scaffold ◽  
Drug Sustained Release

Preparation and antibacterial activity of chitosan derivative membrane complexation with iodine

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 79820-79828 ◽  
Author(s):  
Ningning Xu ◽  
Derun Ding
Keyword(s):  
Antibacterial Activity ◽  
Sustained Release ◽  
Chitosan Derivative ◽  
E Coli ◽  
Resultant Material

A chitosan based material with a polyvinylpyrrolidone membrane was prepared and used to adsorb iodine. The resultant material exhibited the sustained-release of iodine, and significant antibacterial activity against E. coli and S. aureus.

An amorphous calcium phosphate nanocomposite for storing and sustained release of IgY protein with antibacterial activity

RSC Advances ◽  
2015 ◽  
Vol 5 (122) ◽  
pp. 100682-100688 ◽  
Author(s):  
Feng Chen ◽  
Bin Yang ◽  
Chao Qi ◽  
Tuan-Wei Sun ◽  
Ying-Ying Jiang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Calcium Phosphate ◽  
Sustained Release ◽  
Amorphous Calcium Phosphate ◽  
Antibacterial Study ◽  
La Doping

Amorphous calcium phosphate nanospheres with/without La doping are prepared and used for IgY storing, sustained release and antibacterial study.

scholarly journals Synthesis, antibacterial activities, and sustained perfume release properties of optically active5-hydroxy- and 5-acetoxyalkanethioamide analogues

2020 ◽  
Vol 26 (1) ◽  
pp. 84-98
Author(s):  
Yasutaka Shimotori ◽  
Masayuki Hoshi ◽  
Narihito Ogawa ◽  
Tetsuo Miyakoshi ◽  
Taisei Kanamoto
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Sustained Release ◽  
Antibacterial Properties ◽  
Antibacterial Activities ◽  
Optically Active ◽  
High Antibacterial Activity ◽  
Subsequent Deacetylation

Abstract5-Acetoxy- and 5-hydroxyalkanethioamide analogues showed high antibacterial activity against Staphylococcus aureus. Antibacterial thioamides were prepared from 5-alkyl-δ-lactones by amidation, thionation, and subsequent deacetylation. Optically active thioamides with 99% diastereomeric excesses were prepared by diastereomeric resolution using Cbz-L-proline as the resolving agent. Antibacterial thioamides were slowly lactonized by a lipase catalyst. Therefore, these thioamides are potential sustained-release perfume compounds having antibacterial properties.

Supramolecular Hydrogels Sustained Release Triclosan with Controlled Antibacterial Activity and Limited Cytotoxicity

2013 ◽  
Vol 5 (10) ◽  
pp. 1400-1409 ◽  
Author(s):  
Dong Ma ◽  
Ting Wu ◽  
Jinglin Zhang ◽  
Minsong Lin ◽  
Wenjie Mai ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Sustained Release

scholarly journals Sulfonated porous surface of tantalum pentoxide/polyimide composite with micro-submicro structures displaying antibacterial performances and stimulating cell responses

2020 ◽  
Vol 190 ◽  
pp. 108510 ◽  
Author(s):  
Syed Asadullah ◽  
Shiqi Mei ◽  
Deqiang Wang ◽  
Yuan Yao ◽  
Yongkang Pan ◽  
...  
Keyword(s):  
Tantalum Pentoxide ◽  
Porous Surface ◽  
Cell Responses

Enhanced curcumin solubility and antibacterial activity by encapsulation in PLGA oily core nanocapsules

2020 ◽  
Vol 11 (1) ◽  
pp. 448-455 ◽  
Author(s):  
Mengqian Gao ◽  
Xue Long ◽  
Jing Du ◽  
Mengting Teng ◽  
Weichen Zhang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Sustained Release

PLGA oily core CUR NCs show higher solubility, sustained release and enhanced antibacterial activity.

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