scholarly journals TMT-based quantitative proteome profiles reveal the memory function of whole heart decellularized matrix for neural stem cells trans-differentiation into cardiac lineage

2021 ◽  
Author(s):  
Changyong Wang ◽  
Xiaoning Yang ◽  
Xiao Zhang ◽  
Baijun Liu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Memory Function ◽  
Specific Memory ◽  
Cardiac Lineage ◽  
Whole Heart

Whole organ or tissue decellularized matrix is a promising scaffold for tissue engineering because of maintaining the specific memory of the original organ or tissue. Whole organ or tissue decellularized...

Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in the RCCS system facilitate locomotor functional recovery in spinal cord injury animals

2022 ◽  
Author(s):  
Jianwu Dai ◽  
Yunlong Zou ◽  
Yanyun Yin ◽  
Zhifeng Xiao ◽  
Yannan Zhao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Tissue Engineering ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Three Dimensional ◽  
Collagen Sponge ◽  
Cellular Functions ◽  
Cord Injury ◽  
Cells Cultured

Numerous studies have indicated that microgravity induces various changes in the cellular functions of neural stem cells (NSCs), and the use of microgravity to culture tissue engineering seed cells for...

scholarly journals Effects of Graphene-Based Materials on the Behavior of Neural Stem Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
Yan Zhang ◽  
Shu Wang ◽  
Ping Yang
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Neural Stem Cells ◽  
Transverse Myelitis ◽  
Neural Tissue ◽  
Research Field ◽  
Benign Tumors ◽  
Neural Tissue Engineering ◽  
Coating Materials ◽  
Differentiation And Proliferation

Neural tissue engineering is a research field aimed at rebuilding neurological defects resulting from severe trauma, vascular impairment, syringomyelia, spinal stenosis, malignant and benign tumors, or transverse myelitis. Of particular interest, neural stem cells (NSCs) and the effective differentiation and proliferation thereof are attractive research areas that have yielded widespread utility for implants or neural scaffold materials. Graphene and its derivatives have more effective and efficient physical, chemical, and biological abilities than other nanomaterials, and may act as new coating materials to promote neuronal proliferation and differentiation. Therefore, here, we review the recent progress of studies that examine the effect of graphene-based materials on NSCs. We specifically review how graphene and its derivatives influence NSC adhesion, differentiation, and proliferation. We also discuss the risks of graphene-based materials, including their anti-inflammatory effects, in the realm of neural tissue engineering as well as current challenges facing the field today.

Neural stem cell therapy for neuropsychiatric disorders

2007 ◽  
Vol 19 (1) ◽  
pp. 11-26 ◽  
Author(s):  
Michael Valenzuela ◽  
Kuldip Sidhu ◽  
Sophia Dean ◽  
Perminder Sachdev
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Neural Stem Cells ◽  
Memory Function ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Living Organism ◽  
Neuropsychiatric Disorders

Objective:To conduct a comprehensive literature review of the area of neural stem cells and neuropsychiatry.Methods:‘Neural stem cells’ (NSCs) and ‘neurogenesis’ were used as keywords in Medline (1966 – November 2006) to identify relevant papers in the areas of Alzheimer’s disease (AD), depression, schizophrenia and Parkinson’s disease (PD). This list was supplemented with papers from reference lists of seminal reviews.Results:The concept of a ‘stem cell’ continues to evolve and is currently defined by operational criteria related to symmetrical renewal, multipotency and functional viability. In vivo adult mammalian neurogenesis occurs in discrete niches in the subventricular and subgranular zones – however, functional precursor cells can be generated in vitro from a wide variety of biological sources. Both artificial and physiological microenvironment is therefore critical to the characteristics and behaviour of neural precursors, and it is not straightforward how results from the laboratory can be extrapolated to the living organism. Transplant strategies in PD have shown that it is possible for primitive neural tissue to engraft into neuropathic brain areas, become biologically functional and lead to amelioration of clinical signs and symptoms. However, with long-term follow-up, significant problems related to intractable side-effects and potential neoplastic growth have been reported. These are therefore the potentials and pitfalls for NSC technology in neuropsychiatry. In AD, the physiology of amyloid precursor protein may directly interact with NSCs, and a role in memory function has been speculated. The role of endogenous neurogenesis has also been implicated in the etiology of depression. The significance of NSCs and neurogenesis for schizophrenia is still emerging.Conclusions:There are a number of technical and conceptual challenges ahead before the promise of NSCs can be harnessed for the understanding and treatment of neuropsychiatric disorders. Further research into fundamental NSC biology and how this interacts with the neuropsychiatric disease processes is required.

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