scholarly journals Development of wound healing scaffolds with precisely-triggered sequential release of therapeutic nanoparticles

2021 ◽  
Author(s):  
Tauseef Ahmad ◽  
Sean McGrath ◽  
Catherine Sirafim ◽  
Ronaldo J. F. C. do Amaral ◽  
Shin-Loong Soong ◽  
...  
Keyword(s):  
Wound Healing ◽  
On Demand ◽  
Sequential Release

Collagen-glycosaminoglycan scaffolds are functionalized with alginate that responds to ultrasound by releasing nanoparticles on-demand for coordinated wound healing.

Near infrared light-triggered on-demand Cur release from Gel-PDA@Cur composite hydrogel for antibacterial wound healing

2021 ◽  
Vol 403 ◽  
pp. 126182 ◽  
Author(s):  
Bailong Tao ◽  
Chuanchuan Lin ◽  
Zhang Yuan ◽  
Ye He ◽  
Maowen Chen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Near Infrared ◽  
Composite Hydrogel ◽  
Infrared Light ◽  
Near Infrared Light ◽  
On Demand

scholarly journals Imination of Microporous Chitosan Fibers—A Route to Biomaterials with “On Demand” Antimicrobial Activity and Biodegradation for Wound Dressings

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 117
Author(s):  
Alexandru Anisiei ◽  
Irina Rosca ◽  
Andreea-Isabela Sandu ◽  
Adrian Bele ◽  
Xinjian Cheng ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Wound Healing ◽  
Antimicrobial Agents ◽  
Dermal Fibroblast ◽  
Intermolecular Forces ◽  
Wound Dressings ◽  
Conversion Degree ◽  
Fiber Morphology ◽  
On Demand ◽  
Vis Spectroscopy

Microporous chitosan nanofibers functionalized with different amounts of an antimicrobial agent via imine linkage were prepared by a three-step procedure including the electrospinning of a chitosan/PEO blend, PEO removal and acid condensation reaction in a heterogeneous system with 2-formylphenylboronic acid. The fibers’ characterization was undertaken keeping in mind their application to wound healing. Thus, by FTIR and 1H-NMR spectroscopy, it was confirmed the successful imination of the fibers and the conversion degree of the amine groups of chitosan into imine units. The fiber morphology in terms of fiber diameter, crystallinity, inter- and intra-fiber porosity and strength of intermolecular forces was investigated using scanning electron microscopy, polarized light microscopy, water vapor sorption and thermogravimetric analysis. The swelling ability was estimated in water and phosphate buffer by calculating the mass equilibrium swelling. The fiber biodegradation was explored in five media of different pH, corresponding to different stages of wound healing and the antimicrobial activity against the opportunistic pathogens inflicting wound infection was investigated according to standard tests. The biocompatibility and bioadhesivity were studied on normal human dermal fibroblast cells by direct contact procedure. The dynamic character of the imine linkage of the functionalized fibers was monitored by UV-vis spectroscopy. The results showed that the functionalization of the chitosan microporous nanofibers with antimicrobial agents via imine linkage is a great route towards bio-absorbable wound dressings with “on demand” antimicrobial properties and biodegradation rate matching the healing stages.

Multifunctional Dynamic Enamine‐Based Hydrogels with On‐Demand Removability for Wound Healing

2021 ◽  
pp. 2101855
Author(s):  
Fanwei Zeng ◽  
Xueyu Jiang ◽  
Hao Zhang ◽  
Minzhang Chen ◽  
Ang Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
On Demand
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