Utilization of click chemistry to study the effect of poly(ethylene)glycol molecular weight on the self-assembly of PEGylated gambogic acid nanoparticles for the treatment of rheumatoid arthritis

2020 ◽  
Vol 8 (16) ◽  
pp. 4626-4637 ◽  
Author(s):  
Anne Nguyen ◽  
Hidenori Ando ◽  
Roland Böttger ◽  
K. K. DurgaRao Viswanadham ◽  
Elham Rouhollahi ◽  
...  

Click chemistry was used to study the effect of varied PEG molecular weights on the self-assembly of PEG-gambogic acid (GA) conjugates into nanoparticles.

RSC Advances ◽  
2015 ◽  
Vol 5 (91) ◽  
pp. 74744-74752 ◽  
Author(s):  
J. Dey ◽  
N. Sultana ◽  
S. Kumar ◽  
V. K. Aswal ◽  
S. Choudhury ◽  
...  

The role of PEG's of different molecular weights on the self-assembly of SDS and the role of added NaCl has been addressed opening new scopes for further studies.


2015 ◽  
Vol 3 (34) ◽  
pp. 6945-6952 ◽  
Author(s):  
Carmen Stoffelen ◽  
Eugenio Staltari-Ferraro ◽  
Jurriaan Huskens

The length and valency of PEG-based stopper molecules have a pronounced effect on the self-assembly, size, stability and dynamics of supramolecular nanoparticles.


2003 ◽  
Vol 18 (3) ◽  
pp. 737-741 ◽  
Author(s):  
Shuhui Yu ◽  
Kui Yao ◽  
Santiranjan Shannigrahi ◽  
Francis Tay Eng Hock

Poly(ethylene glycol) (PEG) additives with different molecular weights were used to modify sol-gel precursor solutions for preparing lead zirconate titanate (PZT) thin films. The morphology, crystalline structure, and mechanical and electrical properties of the films were characterized. The relationship between the characteristics of the films and the molecular weight of PEG was investigated. It was observed that the PEG eliminated cracking of the films during multiple pyrolysis treatments. However, with the increase of the PEG molecular weight, the films became less dense, which led to decreased Young's modulus and dielectric constant and increased coercive field. Our experiments showed that films prepared from sols modified by PEG with a molecular weight of 200 exhibited a dense morphology and excellent mechanical and electric properties without cracking.


2020 ◽  
Vol 82 (12) ◽  
pp. 2847-2856
Author(s):  
Qi Wang ◽  
Fengna Dai ◽  
Shangying Zhang ◽  
Chunhai Chen ◽  
Youhai Yu

Abstract A new kind of flat sheet ultrafiltration membrane was prepared by a promising membrane material, poly (aryl ether nitrile) (PEN), via non-solvent induced phase separation. The effect of solvents, N-methyl-2-pyrrolidone (NMP) and dimethyl acetamide (DMAc), as well as additive of poly (ethylene glycol) (PEG) with different molecular weights on the structure and permeation performance of synthesized membranes were investigated. Comparing with NMP, DMAc is more suitable for the casting solution preparation due to better solubility. A gradually changing pore from sponge-like to finger-like can be observed when PEG was added with DMAc as solvent, while a finger-like pore structure always appears in the NMP system with or without PEG. In both systems, the formation of macrovoids is effectively promoted by the addition of PEG, and higher porosity membranes can be obtained by PEG with higher molecular weight. With the increase of PEG molecular weight from 400 to 10,000 Da, the permeate flux increases from 74.5 to 114.3 L·m−2·h−1 and from 102.0 to 130.8 L·m−2·h−1 under a 100 kPa pressure-driven when NMP and DMAc were used as solvents, respectively. The membranes prepared by DMAc exhibit outstanding rejection of BSA with rejections all above 96.5%.


2020 ◽  
Vol 11 (2) ◽  
pp. 275-280 ◽  
Author(s):  
Imke A. B. Pijpers ◽  
Fenghua Meng ◽  
Jan C. M. van Hest ◽  
Loai K. E. A. Abdelmohsen

Different ratios between THF and dioxane were used to study the effect of organic solvent composition on the self-assembly and subsequent shape-change of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes.


RSC Advances ◽  
2016 ◽  
Vol 6 (63) ◽  
pp. 58160-58172 ◽  
Author(s):  
Y. Chen ◽  
Y. X. Zhang ◽  
Z. F. Wu ◽  
X. Y. Peng ◽  
T. Su ◽  
...  

The self-assembly and drug release of the three PEG–PCL copolymers with different topologies but identical molar ratio between PEG to PCL.


2015 ◽  
Vol 3 (8) ◽  
pp. 1218-1227 ◽  
Author(s):  
Feng Liu ◽  
Yufei Ma ◽  
Lei Xu ◽  
Lichao Liu ◽  
Weian Zhang

A supramolecular photosensitizer delivery system has been established through the self-assembly of supramolecular amphiphiles constructed by the host–guest interaction between poly(ethylene glycol)-β-cyclodextrin (PEG-β-CD) and adamantane-terminated porphyrin derivatives bearing a disulfide bond (TPPC6-SS-Ada).


2007 ◽  
Vol 21 (28n29) ◽  
pp. 4961-4966
Author(s):  
HUI-RU MA ◽  
JIAN-GUO GUAN ◽  
RUN-ZHANG YUAN

The self-assembly properties and ER effects of the Polyaniline-Poly(ethylene glycol)-Polyaniline (PAn-PEG-PAn) triblock copolymers were studied in this paper. The results indicate that with the increase of solubility parameter of the solvent, PAn-PEG-PAn copolymers form into different morphologies of spheriods, vesicles and rods. PAn-PEG-PAn copolymers with vesicles morphology show the highest polarization strength, while those with rods have the most rapid polarization rate. Among the PAn-PEG-PAn copolymers of different morphologies, the PAn-PEG-PAn copolymer vesicles show the strongest ER effect.


Langmuir ◽  
2019 ◽  
Vol 36 (1) ◽  
pp. 311-317 ◽  
Author(s):  
Wenjie Wang ◽  
Hyeong Jin Kim ◽  
Wei Bu ◽  
Surya Mallapragada ◽  
David Vaknin

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