scholarly journals Wound healing properties of magnesium mineralized antimicrobial nanofibre dressings containing chondroitin sulphate – a comparison between blend and core–shell nanofibres

2020 ◽  
Vol 8 (12) ◽  
pp. 3454-3471 ◽  
Author(s):  
Chak Ming Leung ◽  
Chetna Dhand ◽  
Venkatesh Mayandi ◽  
Raghavendra Ramalingam ◽  
Fui Ping Lim ◽  
...  
Keyword(s):  
Wound Healing ◽  
Porcine Model ◽  
Chondroitin Sulphate ◽  
Core Shell ◽  
Skin Cells ◽  
Partial Thickness ◽  
Partial Thickness Burns ◽  
Shell Composite ◽  
Chondroitin Sulphate A

Effect of chondroitin sulphate incorporated PCL/gelatin as blends or core–shell composite nanofibres are compared in terms of their biocompatibility for skin cells and wound healing in porcine model of partial thickness burns.

The Role of Autologous PRP on Deep Partial-Thickness Burn Wound Healing in Bama Pigs

2020 ◽  
Vol 41 (3) ◽  
pp. 657-662 ◽  
Author(s):  
Yanwei Sun ◽  
Yongqian Cao ◽  
Ran Zhao ◽  
Famei Xu ◽  
Dan Wu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Growth Factor ◽  
Healing Process ◽  
Control Group ◽  
Therapeutic Effects ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
The Mean ◽  
Partial Thickness Burns

Abstract In this study, we aimed to evaluate the therapeutic effects of autologous platelet-rich plasma (PRP) on deep partial-thickness burns in Bama pigs. Deep partial-thickness burn wounds were created on the back of Bama pigs. The reepithelialization time was compared between the PRP and control groups. The mean score of Ki67 (+) cells and α-SMA (+) vessels, the mean thickness of epidermis and dermis of the healing wounds were determined via H&E staining and immunohistochemical assay. The levels of the growth factors epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF) were examined by ELISA. Our data showed that the time to wound reepithelialization was shorter in the PRP group compared with the control group. The thickness of the epidermis was larger in the PRP group compared with the control group. On the 7th and 14th days after the treatment, the mean score of Ki67 (+) cells and α-SMA (+) vessels were higher in the PRP group compared with the control group. The PRP group showed higher levels of growth factors (EGF, bFGF, and VEGF) compared with the control group by ELISA. The results indicated that PRP could improve wound healing process of deep partial-thickness burns in Bama pigs. The PRP increased the thickness of epidermis of the healed wounds, cell proliferation, and angiogenesis. We demonstrated that applying PRP had a greater potential for the treatment of deep partial-thickness burns.

scholarly journals Early nonsurgical removal of chemically injured tissue enhances wound healing in partial thickness burns

Burns ◽  
1998 ◽  
Vol 24 (2) ◽  
pp. 166-172 ◽  
Author(s):  
A. Eldad ◽  
A. Weinberg ◽  
S. Breiterman ◽  
M. Chaouat ◽  
D. Palanker ◽  
...  
Keyword(s):  
Wound Healing ◽  
Injured Tissue ◽  
Partial Thickness ◽  
Partial Thickness Burns

scholarly journals The wound-healing effects of a next-generation anti-biofilm silver Hydrofiber wound dressing on deep partial-thickness wounds using a porcine model

2018 ◽  
Vol 15 (5) ◽  
pp. 834-839 ◽  
Author(s):  
Stephen C. Davis ◽  
Jie Li ◽  
Joel Gil ◽  
Jose Valdes ◽  
Michael Solis ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Porcine Model ◽  
Next Generation ◽  
Partial Thickness

365 The Effects of Platelet-Rich Plasma on Healing of Partial Thickness Burns in a Porcine Model

2018 ◽  
Vol 39 (suppl_1) ◽  
pp. S153-S153
Author(s):  
A J Singer ◽  
J Toussaint ◽  
W Chung ◽  
S McClain ◽  
N Osman ◽  
...  
Keyword(s):  
Porcine Model ◽  
Platelet Rich Plasma ◽  
Partial Thickness ◽  
Partial Thickness Burns

scholarly journals Evolution of a concept with enzymatic debridement and autologous in situ cell and platelet-rich fibrin therapy (BroKerF)

2022 ◽  
Vol 8 ◽  
pp. 205951312110523
Author(s):  
Matthias Waldner ◽  
Tarek Ismail ◽  
Alexander Lunger ◽  
Holger J Klein ◽  
Riccardo Schweizer ◽  
...  
Keyword(s):  
Fibrin Glue ◽  
Healing Process ◽  
Donor Site ◽  
Total Body Surface Area ◽  
Split Thickness Skin Graft ◽  
Skin Grafts ◽  
Skin Cells ◽  
Partial Thickness ◽  
Partial Thickness Burns ◽  
Enzymatic Debridement

Background Deep partial-thickness burns are traditionally treated by tangential excision and split thickness skin graft (STSG) coverage. STSGs create donor site morbidity and increase the wound surface in burn patients. Herein, we present a novel concept consisting of enzymatic debridement of deep partial-thickness burns followed by co-delivery of autologous keratinocyte suspension and plated-rich fibrin (PRF) or fibrin glue. Material and methods In a retrospective case study, patients with deep partial-thickness burns treated with enzymatic debridement and autologous cell therapy combined with PRF or fibrin glue (BroKerF) between 2017 and 2018 were analysed. BroKerF was applied to up to 15% total body surface area (TBSA); larger injuries were combined with surgical excision and skin grafting. Exclusion criteria were age <18 or >70 years, I°, IIa°-only, III° burns and loss of follow-up. Results A total of 20 patients with burn injuries of 16.8% ± 10.3% TBSA and mean Abbreviated Burn Severity Score 5.45 ± 1.8 were identified. Of the patients, 65% (n = 13) were treated with PRF, while 35% (n = 7) were treated with fibrin glue. The mean area treated with BroKerF was 7.5% ± 0.05% TBSA, mean time to full epithelialization was 21.06 ± 9.2 days and mean hospitalization time was 24.7 ± 14.4 days. Of the patients, 35% (n = 7) needed additional STSG, 43% (n = 3) of whom had biopsy-proven wound infections. Conclusion BroKerF is an innovative treatment strategy, which, in our opinion, will show its efficacy when higher standardization is achieved. The combination of selective debridement and autologous skin cells in a fibrin matrix combines regenerative measures for burn treatment. Lay Summary Patients suffering from large burn wounds often require the use of large skin grafts to bring burned areas to heal. Before the application of skin grafts, the burned skin must be removed either by surgery or using enzymatic agents. In this article, we describe a method where small areas of skin are taken and skin cells are extracted and sprayed on wound areas that were treated with an enzymatic agent. The cells are held in place by a substance extracted from patients’ blood (PRF) that is sprayed on the wound together with the skin cells. We believe this technique can be helpful to reduce the need of skin grafts in burned patients and improve the healing process.

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