Vascularization strategies for skin tissue engineering

2020 ◽  
Vol 8 (15) ◽  
pp. 4073-4094 ◽  
Author(s):  
Armin Amirsadeghi ◽  
Arman Jafari ◽  
Loek J. Eggermont ◽  
Seyedeh-Sara Hashemi ◽  
Sidi A. Bencherif ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Skin Tissue ◽  
Delayed Wound Healing ◽  
Skin Tissue Engineering

Lack of proper vascularization after skin trauma causes delayed wound healing. This has sparked the development of various tissue engineering strategies to improve vascularization.

scholarly journals Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Azar Nourian Dehkordi ◽  
Fatemeh Mirahmadi Babaheydari ◽  
Mohammad Chehelgerdi ◽  
Shiva Raeisi Dehkordi
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Stem Cell ◽  
Therapeutic Strategies ◽  
Skin Tissue ◽  
Skin Tissue Engineering

Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway

2020 ◽  
Vol 52 (10) ◽  
pp. 1102-1110
Author(s):  
Zhaodong Wang ◽  
Guangliang Zhang ◽  
Yingying Le ◽  
Jihui Ju ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Proliferation ◽  
Wound Healing ◽  
Estrogen Receptor ◽  
Signaling Pathway ◽  
Skin Wound ◽  
Skin Tissue ◽  
Skin Wound Healing ◽  
Skin Tissue Engineering ◽  
Cyclin A2

Abstract Skin epidermal stem cells (EpSCs) play an important role in wound healing. Quercetin is a phytoestrogen reported to accelerate skin wound healing, but its effect on EpSCs is unknown. In this study, we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms. We found that quercetin at 0.1~1 μM significantly promoted EpSC proliferation and increased the number of cells in S phase. The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue. Mechanistic studies showed that quercetin significantly upregulated the expressions of β-catenin, c-Myc, and cyclins A2 and E1. Inhibitor for β-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation. The β-catenin inhibitor XAV-939 suppressed quercetin-induced expressions of β-catenin, c-Myc, and cyclins A2 and E1. The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin. Pretreatment of EpSCs with estrogen receptor (ER) antagonist ICI182780, but not the G protein-coupled ER1 antagonist G15, reversed quercetin-induced cell proliferation and upregulation of β-catenin, c-Myc, and cyclin A2. Collectively, these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation of β-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation. As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering, quercetin is a useful reagent to expand EpSCs for basic research, skin wound treatment, and skin tissue engineering.

scholarly journals Immunomodulation of Skin Repair: Cell-Based Therapeutic Strategies for Skin Replacement (A Comprehensive Review)

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 118
Author(s):  
Shima Tavakoli ◽  
Marta A. Kisiel ◽  
Thomas Biedermann ◽  
Agnes S. Klar
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Wound Healing ◽  
Skin Wound ◽  
Skin Tissue ◽  
Diabetic Patients ◽  
Specific Cell ◽  
Skin Substitutes ◽  
Skin Wound Healing ◽  
Skin Tissue Engineering

The immune system has a crucial role in skin wound healing and the application of specific cell-laden immunomodulating biomaterials emerged as a possible treatment option to drive skin tissue regeneration. Cell-laden tissue-engineered skin substitutes have the ability to activate immune pathways, even in the absence of other immune-stimulating signals. In particular, mesenchymal stem cells with their immunomodulatory properties can create a specific immune microenvironment to reduce inflammation, scarring, and support skin regeneration. This review presents an overview of current wound care techniques including skin tissue engineering and biomaterials as a novel and promising approach. We highlight the plasticity and different roles of immune cells, in particular macrophages during various stages of skin wound healing. These aspects are pivotal to promote the regeneration of nonhealing wounds such as ulcers in diabetic patients. We believe that a better understanding of the intrinsic immunomodulatory features of stem cells in implantable skin substitutes will lead to new translational opportunities. This, in turn, will improve skin tissue engineering and regenerative medicine applications.

Nanofibrous scaffolds for skin tissue engineering and wound healing applications

2022 ◽  
pp. 645-681
Author(s):  
Guadalupe Rivero ◽  
Matthäus D. Popov Pereira da Cunha ◽  
Pablo C. Caracciolo ◽  
Gustavo A. Abraham
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Nanofibrous Scaffolds

Polydopamine modification of silk fibroin membranes significantly promotes their wound healing effect

2019 ◽  
Vol 7 (12) ◽  
pp. 5232-5237 ◽  
Author(s):  
Ying Zhang ◽  
Leihao Lu ◽  
Yuping Chen ◽  
Jie Wang ◽  
Yuyin Chen ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Silk Fibroin ◽  
Wound Dressings ◽  
Skin Tissue ◽  
Natural Polymer ◽  
Skin Tissue Engineering ◽  
Healing Effect ◽  
Wound Healing Effect

Natural polymer-based wound dressings have gained great attention in skin tissue engineering.

scholarly journals Stem Cells for Skin Tissue Engineering and Wound Healing

2009 ◽  
Vol 37 (4-5) ◽  
pp. 399-421 ◽  
Author(s):  
Ming Chen ◽  
Melissa Przyborowski ◽  
Francois Berthiaume
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Wound Healing ◽  
Skin Tissue ◽  
Skin Tissue Engineering

scholarly journals Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

2020 ◽  
Author(s):  
Lucie Bacakova ◽  
Julia Pajorova ◽  
Marketa Zikmundova ◽  
Elena Filova ◽  
Petr Mikes ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Skin Tissue ◽  
Skin Tissue Engineering ◽  
Nanofibrous Scaffolds

Bioglass Activated Skin Tissue Engineering Constructs for Wound Healing

2015 ◽  
Vol 8 (1) ◽  
pp. 703-715 ◽  
Author(s):  
Hongfei Yu ◽  
Jinliang Peng ◽  
Yuhong Xu ◽  
Jiang Chang ◽  
Haiyan Li
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Skin Tissue ◽  
Skin Tissue Engineering
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