Highly sensitive detection of DNA methyltransferase activity and its inhibitor screening by coupling fluorescence correlation spectroscopy with polystyrene polymer dots

The Analyst ◽  
2021 ◽  
Author(s):  
Yuyang Huang ◽  
Liyun Deng ◽  
Di Su ◽  
Xiangyi Huang ◽  
Jicun Ren
Keyword(s):  
Dna Methyltransferase ◽  
Cell Function ◽  
Vital Role ◽  
Correlation Spectroscopy ◽  
Methyltransferase Activity ◽  
Fluorescence Correlation ◽  
Genetic Imprinting ◽  
Highly Sensitive ◽  
Polymer Dots ◽  
Highly Sensitive Detection

DNA methylation is a critical part of epigenetics and plays a vital role in maintaining normal cell function, genetic imprinting, and human tumorigenesis. Thus, it is important to develop a...

Viral cDNA-based extension for highly sensitive fluorescence detection of DNA methyltransferase activity

2018 ◽  
Vol 255 ◽  
pp. 3488-3494 ◽  
Author(s):  
Ying Wang ◽  
Binxiao Li ◽  
Ningbo Zhang ◽  
Dongmei Xi ◽  
Jing Liu ◽  
...  
Keyword(s):  
Fluorescence Detection ◽  
Dna Methyltransferase ◽  
Methyltransferase Activity ◽  
Highly Sensitive ◽  
Viral Cdna

Highly Sensitive Method for Assay of Drug-Induced Apoptosis Using Fluorescence Correlation Spectroscopy

2012 ◽  
Vol 84 (17) ◽  
pp. 7350-7358 ◽  
Author(s):  
Lingao Ruan ◽  
Zhancheng Xu ◽  
Tao Lan ◽  
Jinjie Wang ◽  
Heng Liu ◽  
...  
Keyword(s):  
Fluorescence Correlation Spectroscopy ◽  
Correlation Spectroscopy ◽  
Drug Induced ◽  
Fluorescence Correlation ◽  
Highly Sensitive ◽  
Induced Apoptosis ◽  
Sensitive Method
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