scholarly journals Mapping at the nanometer scale the effects of sea-salt derived chlorine on cinnabar and lead white by using delayed image extraction in ToF-SIMS

The Analyst ◽  
2021 ◽  
Author(s):  
M. Iorio ◽  
A. Sodo ◽  
V. Graziani ◽  
P. Branchini ◽  
A. Casanova Municchia ◽  
...  
Keyword(s):  
Analytical Approach ◽  
Imaging Techniques ◽  
Sea Salt ◽  
Nanometer Scale ◽  
Chemical Mapping ◽  
Lead White ◽  
Advanced Imaging ◽  
Tof Sims ◽  
Delayed Image

In this work, an innovative analytical approach focused on the use of advanced imaging techniques for the chemical mapping of degradation and/or restoration products is proposed.

scholarly journals Assessment and Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer: A Comparison of Imaging Modalities and Future Perspectives

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3521
Author(s):  
Valeria Romeo ◽  
Giuseppe Accardo ◽  
Teresa Perillo ◽  
Luca Basso ◽  
Nunzia Garbino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Tumor Response ◽  
Imaging Techniques ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Complete Response ◽  
Mri Imaging ◽  
Future Perspectives ◽  
Advanced Imaging

Neoadjuvant chemotherapy (NAC) is becoming the standard of care for locally advanced breast cancer, aiming to reduce tumor size before surgery. Unfortunately, less than 30% of patients generally achieve a pathological complete response and approximately 5% of patients show disease progression while receiving NAC. Accurate assessment of the response to NAC is crucial for subsequent surgical planning. Furthermore, early prediction of tumor response could avoid patients being overtreated with useless chemotherapy sections, which are not free from side effects and psychological implications. In this review, we first analyze and compare the accuracy of conventional and advanced imaging techniques as well as discuss the application of artificial intelligence tools in the assessment of tumor response after NAC. Thereafter, the role of advanced imaging techniques, such as MRI, nuclear medicine, and new hybrid PET/MRI imaging in the prediction of the response to NAC is described in the second part of the review. Finally, future perspectives in NAC response prediction, represented by AI applications, are discussed.

scholarly journals On imaging, speed, and the future of lymphocyte signaling

2005 ◽  
Vol 201 (4) ◽  
pp. 505-508 ◽  
Author(s):  
Alexander Tarakhovsky
Keyword(s):  
Imaging Techniques ◽  
Roundtable Discussion ◽  
Advanced Imaging ◽  
The Future ◽  
Personal Perspectives ◽  
Imaging Speed

During a recent roundtable discussion, we captured some personal perspectives on the new insight that advanced imaging techniques promise to bring to the study of lymphocyte signaling. The experts present their views on the power of imaging, the problems that need to be overcome, and the potential of the technology.

scholarly journals Advanced Imaging Techniques for Multiphase Flows Analysis

2017 ◽  
Vol 882 ◽  
pp. 012004 ◽  
Author(s):  
A. Amoresano ◽  
G. Langella ◽  
M. Di Santo ◽  
P. Iodice
Keyword(s):  
Multiphase Flows ◽  
Imaging Techniques ◽  
Advanced Imaging

scholarly journals The Complementary Role of ToF-SIMS in the Assessment of Imiquimod Permeated into the Skin from a Microemulsion Dosage Form

2019 ◽  
pp. 196-210
Keyword(s):  
Dosage Form ◽  
Secondary Ion Mass Spectrometry ◽  
Imaging Techniques ◽  
Skin Permeation ◽  
High Sensitivity ◽  
Tof Sims ◽  
Complementary Role ◽  
Nodular Lesions ◽  
Superficial Basal Cell Carcinoma ◽  
Fluorescent Tags

The assessment of drug permeation into/across the skin is traditionally accomplished using Franz diffusion cells with subsequent analysis by conventional chromatographic methods such as HPLC and more recently using advanced imaging techniques. In this context, time of flight-secondary ion mass spectrometry (ToF-SIMS) offers distinctive advantages in mapping drugs within skin with high sensitivity and chemical specificity without the need for fluorescent tags or radiolabels. The work in this paper uses the combination of conventional and advanced methods to evaluate imiquimod permeation into the skin. This approach provides complementary and detailed information regarding the permeated mass, the permeation depth and the spatial distribution and localisation of drugs within skin. Imiquimod is an immune modulator drug approved by the FDA for the treatment of superficial basal cell carcinoma (BCC) but not the nodular lesions. As other studies have reported that Aldara™ cream (imiquimod 5% w/w) has some limitations in the treatment of nodular BCC lesions due to the cream’s inability to deliver imiquimod into the deeper more invasive nodular lesions, an enhancement of imiquimod permeation is thought to be useful to overcome these limitations. Therefore, an attempt to improve delivery of imiquimod into the deeper skin layers using microemulsions was investigated. Imiquimod microemulsions were formulated and characterised in our previous work are now tested for skin permeation enhancement. However, the assessment of imiquimod permeation from the formulated microemulsions using HPLC and ToF-SIMS demonstrated a limited ability of the microemulsions to improve delivery of imiquimod over Aldara™ cream. This was attributed to the poor release of imiquimod from the microemulsion formulas due to the high affinity of imiquimod for the oil phase and the encapsulation of the oil droplets by the S/Co-S mixture. This is thought to be, the first time that ToF-SIMS has been used to assess permeation of imiquimod from a microemulsion dosage form.

scholarly journals Review of advanced imaging techniques

2012 ◽  
Vol 3 (1) ◽  
pp. 22 ◽  
Author(s):  
Liron Pantanowitz ◽  
Yu Chen ◽  
Chia-Pin Liang ◽  
Yang Liu ◽  
AndrewH Fischer ◽  
...  
Keyword(s):  
Imaging Techniques ◽  
Advanced Imaging
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