Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity

The Analyst ◽  
2021 ◽  
Author(s):  
Min Wen ◽  
Chen Li ◽  
Mengyuan Zhang ◽  
Yan Sun ◽  
Fengming Liu ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
High Sensitivity ◽  
Molecular Rotors ◽  
Ratiometric Fluorescence ◽  
Fluorescent Molecular Rotors

A series of fluorescent molecular rotors, acridinium benzoates, were designed for ratiometrically monitoring cellular viscosity with high sensitivity.

scholarly journals A Novel TMTP1-modified Theranostic Nanoplatform for Targeted in Vivo NIR-II Fluorescence Imaging-guided Chemotherapy of Cervical Cancer

2021 ◽  
Author(s):  
Alifu Nuernisha ◽  
Rong Ma ◽  
Lijun Zhu ◽  
Zhong Du ◽  
Shuang Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Blood Vessels ◽  
Fluorescence Imaging ◽  
Spatial Resolution ◽  
Self Assembly ◽  
Tumor Targeting ◽  
High Sensitivity ◽  
High Definition ◽  
Targeting Ability

Abstract BackgroundNear-infrared II (NIR-II, 900-1700 nm) fluorescence bioimaging with advantages of good biosafety, excellent spatial resolution, high sensitivity and contrast, has attracted great attentions in biomedical research fields. However, most nanoprobes used for NIR-II fluorescence imaging have poor tumor-targeting ability and therapeutic efficiency. To overcome these limitations, a novel NIR-II-emissive theranostic nanoplatform for imaging and treatment of cervical cancer was designed and prepared. The NIR-II-emissive dye IR-783 and chemotherapy drug doxorubicin (DOX) were encapsulated into liposomes, and the tumor-targeting peptide TMTP1 was conjugated to the surface of the liposomes to form IR-783-DOX-TMTP1 nanoparticles (NPs) via self-assembly methods.ResultsThe IR-783-DOX-TMTP1 NPs showed strong NIR-II emission, excellent biocompatibility, a long lifetime, and low toxicity. Further, high-definition NIR-II fluorescence microscopy images of ear blood vessels and intratumor blood vessels were obtained from IR-783-DOX-TMTP1 NPs-stained mice with high spatial resolution under 808 nm laser excitation. Moreover, IR-783-DOX-TMTP1 NPs showed strong tumor targeting ability and high efficiently chemotherapeutic character towards cervical tumors. ConclusionsThe novel targeting and NIR-II-emissive IR-783-DOX-TMTP1 NPs have potential in diagnosis and therapy for cervical cancer.

Ratiometric Fluorescence Imaging of Cellular Glutathione

2011 ◽  
Vol 13 (11) ◽  
pp. 2799-2801 ◽  
Author(s):  
Gun-Joong Kim ◽  
Kiwon Lee ◽  
Hyockman Kwon ◽  
Hae-Jo Kim
Keyword(s):  
Fluorescence Imaging ◽  
Ratiometric Fluorescence

scholarly journals Point-of-care Ratiometric Fluorescence Imaging of Tissue for the Diagnosis of Ovarian Cancer

Theranostics ◽  
2019 ◽  
Vol 9 (16) ◽  
pp. 4597-4607 ◽  
Author(s):  
Xiaobo Zhou ◽  
Yawei Liu ◽  
Qiyu Liu ◽  
Luzhe Yan ◽  
Meng Xue ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Fluorescence Imaging ◽  
Point Of Care ◽  
Ratiometric Fluorescence
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