Fragmentation study of tryptophan-derived metabolites induced by electrospray ionization mass spectrometry for highly sensitive analysis

The Analyst ◽  
2021 ◽  
Author(s):  
Daiki Asakawa ◽  
Hajime Mizuno ◽  
Eiji Sugiyama ◽  
Kenichiro Todoroki
Keyword(s):  
Mass Spectrometry ◽  
Detection Limit ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Sensitive Analysis ◽  
Fragment Ions ◽  
Highly Sensitive ◽  
Intense Signal

ESI of tryptophan-derived metabolites produced an intense signal of fragment ion with a spiro[cyclopropane-indolium] backbone. The use of corresponding fragment ions for the precursor of MRM transitions could improve the detection limit.

Separation and sensitive determination of sphingolipids at low femtomole level by using HPLC-PIESI-MS/MS

The Analyst ◽  
2014 ◽  
Vol 139 (17) ◽  
pp. 4169-4175 ◽  
Author(s):  
Chengdong Xu ◽  
Eduardo Costa Pinto ◽  
Daniel W. Armstrong
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Trace Determination ◽  
Highly Sensitive ◽  
Sensitive Determination ◽  
Paired Ion Electrospray Ionization

A highly sensitive paired ion electrospray ionization mass spectrometry (PIESI-MS) approach was developed for the trace determination of sphingolipids.

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