Light-accelerating oxidase-mimicking activity of black phosphorus quantum dots for colorimetric detection of acetylcholinesterase activity and inhibitor screening

The Analyst ◽  
2020 ◽  
Vol 145 (24) ◽  
pp. 8022-8029
Author(s):  
Lei Ren ◽  
Hongdan Li ◽  
Mei Liu ◽  
Jianxiu Du
Keyword(s):  
Quantum Dots ◽  
Colorimetric Assay ◽  
Colorimetric Detection ◽  
Acetylcholinesterase Activity ◽  
Black Phosphorus ◽  
Light Irradiation ◽  
Inhibitor Screening ◽  
Black Phosphorus Quantum Dots

The exposure of 365 nm light irradiation significantly accelerates the oxidase-mimicking activity of black phosphorus quantum dots, allowing sensitive colorimetric assay of acetylcholinesterase activity and evaluation of its inhibitor screening.

Sequentially Triggered Delivery System of Black Phosphorus Quantum Dots with Surface Charge-Switching Ability for Precise Tumor Radiosensitization

ACS Nano ◽  
2018 ◽  
Vol 12 (12) ◽  
pp. 12401-12415 ◽  
Author(s):  
Leung Chan ◽  
Pan Gao ◽  
Wenhua Zhou ◽  
Chaoming Mei ◽  
Yanyu Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Surface Charge ◽  
Delivery System ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

scholarly journals Tea polyphenol modified, photothermal responsive and ROS generative black phosphorus quantum dots as nanoplatforms for promoting MRSA infected wounds healing in diabetic rats

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Shibo Xu ◽  
Linna Chang ◽  
Yanan Hu ◽  
Xingjun Zhao ◽  
Shuocheng Huang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Wound Healing ◽  
Bacterial Infections ◽  
Photocatalytic Property ◽  
Black Phosphorus ◽  
Control Group ◽  
Ros Generation ◽  
Diabetic Patients ◽  
Photocatalytic Ability ◽  
Black Phosphorus Quantum Dots

Abstract Background Healing of MRSA (methicillin-resistant Staphylococcus aureus) infected deep burn wounds (MIDBW) in diabetic patients remains an obstacle but is a cutting-edge research problem in clinical science. Surgical debridement and continuous antibiotic use remain the primary clinical treatment for MIDBW. However, suboptimal pharmacokinetics and high doses of antibiotics often cause serious side effects such as fatal complications of drug-resistant bacterial infections. MRSA, which causes wound infection, is currently a bacterium of concern in diabetic wound healing. In more severe cases, it can even lead to amputation of the patient's limb. The development of bioactive nanomaterials that can promote infected wound healing is significant. Results The present work proposed a strategy of using EGCG (Epigallocatechin gallate) modified black phosphorus quantum dots (BPQDs) as therapeutic nanoplatforms for MIDBW to achieve the synergistic functions of NIR (near-infrared)-response, ROS-generation, sterilization, and promoting wound healing. The electron spin resonance results revealed that EGCG-BPQDs@H had a more vital photocatalytic ability to produce singlet oxygen than BPQDs@H. The inhibition results indicated an effective bactericidal rate of 88.6% against MRSA. Molecular biology analysis demonstrated that EGCG-BPQDs significantly upregulated CD31 nearly fourfold and basic fibroblast growth factor (bFGF) nearly twofold, which were beneficial for promoting the proliferation of vascular endothelial cells and skin epidermal cells. Under NIR irradiation, EGCG-BPQDs hydrogel (EGCG-BPQDs@H) treated MIDBW area could rapidly raise temperature up to 55 °C for sterilization. The MIBDW closure rate of rats after 21 days of treatment was 92.4%, much better than that of 61.1% of the control group. The engineered EGCG-BPQDs@H were found to promote MIDBW healing by triggering the PI3K/AKT and ERK1/2 signaling pathways, which could enhance cell proliferation and differentiation. In addition, intravenous circulation experiment showed good biocompatibility of EGCG-BPQDs@H. No significant damage to major organs was observed in rats. Conclusions The obtained results demonstrated that EGCG-BPQDs@H achieved the synergistic functions of photocatalytic property, photothermal effects and promoted wound healing, and are promising multifunctional nanoplatforms for MIDBW healing in diabetics. Graphical Abstract

Surface charge transfer doping of monolayer molybdenum disulfide by black phosphorus quantum dots

2016 ◽  
Vol 27 (50) ◽  
pp. 505204 ◽  
Author(s):  
Wei Wang ◽  
Xinyue Niu ◽  
Haolei Qian ◽  
Liao Guan ◽  
Ming Zhao ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Charge Transfer ◽  
Surface Charge ◽  
Molybdenum Disulfide ◽  
Black Phosphorus ◽  
Black Phosphorus Quantum Dots

Black phosphorus quantum dots as dual-functional electron-selective materials for efficient plastic perovskite solar cells

2018 ◽  
Vol 6 (19) ◽  
pp. 8886-8894 ◽  
Author(s):  
Nianqing Fu ◽  
Chun Huang ◽  
Peng Lin ◽  
Mingshan Zhu ◽  
Tao Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Solar Cells ◽  
Quantum Dot ◽  
High Efficiency ◽  
Perovskite Solar Cells ◽  
Black Phosphorus ◽  
Selective Layer ◽  
Dual Functional ◽  
Black Phosphorus Quantum Dots ◽  
Electron Extraction

Dual-functional black phosphorus quantum dot electron selective layer was designed for plastic perovskite solar cells. The efficient electron extraction and improved perovskite film quality contributed to the reasonably high efficiency.

Solution processed black phosphorus quantum dots for high performance silicon/organic hybrid solar cells

2018 ◽  
Vol 217 ◽  
pp. 92-95 ◽  
Author(s):  
Qingduan Li ◽  
Jianwei Yang ◽  
Chun Huang ◽  
Shaozhong Zeng ◽  
Jizhao Zou ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Solar Cells ◽  
High Performance ◽  
Black Phosphorus ◽  
Hybrid Solar Cells ◽  
Solution Processed ◽  
Organic Hybrid ◽  
Black Phosphorus Quantum Dots
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