Field induced fragmentation spectra from reactive stage-tandem differential mobility spectrometry

The Analyst ◽  
2020 ◽  
Vol 145 (15) ◽  
pp. 5314-5324
Author(s):  
P. E. Fowler ◽  
J. Z. Pilgrim ◽  
G. Lee ◽  
G. A. Eiceman
Keyword(s):  
Differential Mobility Spectrometry ◽  
Differential Mobility ◽  
Fragment Ions ◽  
Differential Mobility Spectrometer

A planar tandem differential mobility spectrometer was integrated with a middle reactive stage to fragment ions which were mobility selected in a first analyzer stage using characteristic compensation and separation fields.

FIELD INDUCED DISPLACEMENT REACTIONS WITH PROTON BOUND DIMERS OF ORGANOPHOSPHORUS COMPOUNDS IN A TANDEM DIFFERENTIAL MOBILITY SPECTROMETER

The Analyst ◽  
2021 ◽  
Author(s):  
Peter E. Fowler ◽  
Jacob Zachary Pilgrim ◽  
Marlen Menlyadiev ◽  
Gary A Eiceman
Keyword(s):  
Organophosphorus Compounds ◽  
Ambient Pressure ◽  
Differential Mobility Spectrometry ◽  
Differential Mobility ◽  
Differential Mobility Spectrometer ◽  
Displacement Reactions

Endothermic displacement reactions between proton bound dimers of organophosphorus compounds (OPCs) and isopropanol (IPA) were enabled in air at ambient pressure with tandem differential mobility spectrometry (DMS). Proton bound dimers...

Differentiation of aspirated nasal air from room air using analysis with a differential mobility spectrometry-based electronic nose: a proof-of-concept study

2021 ◽  
Author(s):  
Jussi Virtanen ◽  
Anna Anttalainen ◽  
Jaakko Ormiskangas ◽  
Markus Karjalainen ◽  
Anton Kontunen ◽  
...  
Keyword(s):  
Electronic Nose ◽  
Point Of Care ◽  
Statistical Significance ◽  
Differential Mobility Spectrometry ◽  
Differential Mobility ◽  
Electronic Noses ◽  
Linear Discriminant ◽  
Differential Mobility Spectrometer ◽  
Kolmogorov Smirnov ◽  
Electronic Nose Technology

Abstract Over the last few decades, breath analysis using electronic nose technology has become a topic of intense research, as it is both non-invasive and painless, and is suitable for point-of-care use. To date, however, only a few studies have examined nasal air. As the air in the oral cavity and the lungs differs from the air in the nasal cavity, it is unknown whether aspirated nasal air could be exploited with electronic nose technology. Compared to traditional electronic noses, differential mobility spectrometry uses an alternating electrical field to discriminate the different molecules of gas mixtures, providing analogous information. This study reports the collection of nasal air by aspiration and the subsequent analysis of the collected air using a differential mobility spectrometer. We collected nasal air from ten volunteers into breath collecting bags and compared them to bags of room air and the air aspirated through the device. Distance and dissimilarity metrics between the sample types were calculated and statistical significance evaluated with Kolmogorov-Smirnov test. After leave-one-day-out cross-validation, a shrinkage linear discriminant classifier was able to correctly classify 100% of the samples. The nasal air differed (p < 0.05) from the other sample types. The results show the feasibility of collecting nasal air by aspiration and subsequent analysis using differential mobility spectrometry, and thus increases the potential of the method to be used in disease detection studies.

Predicting Differential Ion Mobility Behaviour in silico using Machine Learning

The Analyst ◽  
2021 ◽  
Author(s):  
Christian Ieritano ◽  
J. Larry Campbell ◽  
Scott Hopkins
Keyword(s):  
Machine Learning ◽  
Parameter Space ◽  
Ion Mobility ◽  
In Silico ◽  
Differential Mobility Spectrometry ◽  
Differential Mobility ◽  
Mobility Behaviour ◽  
Separation Conditions

Although there has been a surge in popularity of differential mobility spectrometry (DMS) within analytical workflows, determining separation conditions within the DMS parameter space still requires manual optimization. A means...

scholarly journals Possible strategy to use differential mobility spectrometry in real time applications

2019 ◽  
Vol 23 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Osmo Anttalainen ◽  
Jaroslaw Puton ◽  
Anton Kontunen ◽  
Markus Karjalainen ◽  
Pekka Kumpulainen ◽  
...  
Keyword(s):  
Real Time ◽  
Differential Mobility Spectrometry ◽  
Differential Mobility ◽  
Real Time Applications

Rapid pre-filtering of amphetamine and derivatives by direct analysis in real time (DART)-differential mobility spectrometry (DMS)

2017 ◽  
Vol 9 (34) ◽  
pp. 5044-5051 ◽  
Author(s):  
Ifeoluwa Ayodeji ◽  
Timothy Vazquez ◽  
Ronelle Bailey ◽  
Theresa Evans-Nguyen
Keyword(s):  
Real Time ◽  
Direct Analysis ◽  
Differential Mobility Spectrometry ◽  
New Psychoactive Substances ◽  
Psychoactive Substances ◽  
Differential Mobility ◽  
Rapid Separation

Herein, DART ionization was coupled to DMS to demonstrate their combined utility and compatibility for rapid separation and characterization of new psychoactive substances.

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