scholarly journals XLVII.—Nitrogen halogen derivatives of the aliphatic diamines

1905 ◽  
Vol 87 (0) ◽  
pp. 381-388 ◽  
Author(s):  
Frederick Daniel Chattaway
Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4266 ◽  
Author(s):  
Mariya I. Meschaninova ◽  
Darya S. Novopashina ◽  
Olga A. Semikolenova ◽  
Vladimir N. Silnikov ◽  
Alya G. Venyaminova

A novel and convenient approach for the solid-phase 5′-functionalization of oligonucleotides is proposed in this article. The approach is based on the activation of free 5′-hydroxyl of polymer support-bound protected oligonucleotides by N,N′-disuccinimidyl carbonate followed by interaction with amino-containing ligands. Novel amino-containing derivatives of closo-dodecaborate, estrone, cholesterol, and α-tocopherol were specially prepared. A wide range of oligonucleotide conjugates bearing closo-dodecaborate, short peptide, pyrene, lipophilic residues (cholesterol, α-tocopherol, folate, estrone), aliphatic diamines, and propargylamine were synthesized and characterized to demonstrate the versatility of the approach. The developed method is suitable for the conjugate synthesis of oligonucleotides of different types (ribo-, deoxyribo-, 2′-O-methylribo-, and others).


1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik

2002 ◽  
Vol 23 (2) ◽  
pp. 125-207 ◽  
Author(s):  
Igor D. Sadekov ◽  
Alexander V. Zakharov ◽  
Alexander A. Maksimenko
Keyword(s):  

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