Fine tuning of pyridinium-functionalized dibenzo[a,c]phenazine near-infrared AIE fluorescent biosensors for the detection of lipopolysaccharide, bacterial imaging and photodynamic antibacterial therapy

2019 ◽  
Vol 7 (40) ◽  
pp. 12509-12517 ◽  
Author(s):  
Xianglong Liu ◽  
Zhicheng Yang ◽  
Weibo Xu ◽  
Yanmeng Chu ◽  
Ji Yang ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Antibacterial Therapy ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Alkyl Chain ◽  
Antibacterial Property ◽  
Fine Tuning ◽  
Fluorescent Biosensors ◽  
Oxygen Yield ◽  
Pyridine Salt

A series of NIR fluorescent probes of dibenzophenazine pyridine salt with different alkyl chain were developed for the detection of LPS. BD2C with ethyl chain exhibited a significant improvement of the singlet oxygen yield and antibacterial property.

scholarly journals New Approach in the Application of Conjugated Polymers: The Light-Activated Source of Versatile Singlet Oxygen Molecule

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1098
Author(s):  
Agata Blacha-Grzechnik
Keyword(s):  
Conjugated Polymers ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Photophysical Properties ◽  
Short Review ◽  
The Novel ◽  
New Approach ◽  
Intermolecular Energy ◽  
Intermolecular Energy Transfer ◽  
High Absorption

For many years, the research on conjugated polymers (CPs) has been mainly focused on their application in organic electronics. Recent works, however, show that due to the unique optical and photophysical properties of CPs, such as high absorption in UV–Vis or even near-infrared (NIR) region and efficient intra-/intermolecular energy transfer, which can be relatively easily optimized, CPs can be considered as an effective light-activated source of versatile and highly reactive singlet oxygen for medical or catalytic use. The aim of this short review is to present the novel possibilities that lie dormant in those exceptional polymers with the extended system of π-conjugated bonds.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

scholarly journals Photoreactivity of Hair Melanin from Different Skin Phototypes—Contribution of Melanin Subunits to the Pigments Photoreactive Properties

2021 ◽  
Vol 22 (9) ◽  
pp. 4465
Author(s):  
Krystian Mokrzynski ◽  
Shosuke Ito ◽  
Kazumasa Wakamatsu ◽  
Theodore G. Camenish ◽  
Tadeusz Sarna ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Paramagnetic Resonance ◽  
Time Resolved ◽  
W Band ◽  
Epr Oximetry ◽  
X Band ◽  
Hair Samples ◽  
Electron Paramagnetic

Photoreactivity of melanin has become a major focus of research due to the postulated involvement of the pigment in UVA-induced melanoma. However, most of the hitherto studies were carried out using synthetic melanin models. Thus, photoreactivity of natural melanins is yet to be systematically analyzed. Here, we examined the photoreactive properties of natural melanins isolated from hair samples obtained from donors of different skin phototypes (I, II, III, and V). X-band and W-band electron paramagnetic resonance (EPR) spectroscopy was used to examine the paramagnetic properties of the pigments. Alkaline hydrogen peroxide degradation and hydroiodic acid hydrolysis were used to determine the chemical composition of the melanins. EPR oximetry and spin trapping were used to examine the oxygen photoconsumption and photo-induced formation of superoxide anion, and time-resolved near infrared phosphorescence was employed to determine the singlet oxygen photogeneration by the melanins. The efficiency of superoxide and singlet oxygen photogeneration was related to the chemical composition of the studied melanins. Melanins from blond and chestnut hair (phototypes II and III) exhibited highest photoreactivity of all examined pigments. Moreover, melanins of these phototypes showed highest quantum efficiency of singlet oxygen photogeneration at 332 nm and 365 nm supporting the postulate of the pigment contribution in UVA-induced melanoma.

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