Rapid, facile, reagentless, and room-temperature conjugation of monolayer MoS2 nanosheets with dual-fluorophore-labeled flares as nanoprobes for ratiometric sensing of TK1 mRNA in living cells

2020 ◽  
Vol 8 (8) ◽  
pp. 1692-1698 ◽  
Author(s):  
Man-Jyun Wu ◽  
Wei-Lung Tseng
Keyword(s):  
Surface Functionalization ◽  
Room Temperature ◽  
Living Cells ◽  
Monolayer Mos2 ◽  
Mos2 Nanosheets ◽  
Ratiometric Sensing ◽  
Mcf 7

Surface functionalization of MoS2 nanosheets with FRET-based flares was conducted for ratiometric sensing and imaging of TK1 mRNA in HeLa and MCF-7 cells.

Pd Nanocluster/Monolayer MoS2 Heterojunctions for Light-Induced Room-Temperature Hydrogen Sensing

2021 ◽  
Author(s):  
Hien Duy Mai ◽  
Sangmin Jeong ◽  
Tri Khoa Nguyen ◽  
Jong-Sang Youn ◽  
Seungbae Ahn ◽  
...  
Keyword(s):  
Room Temperature ◽  
Monolayer Mos2 ◽  
Hydrogen Sensing

scholarly journals Real-Time Challenging of ERα Y537S Mutant Transcriptional Activity in Living Cells

Endocrines ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 54-64
Author(s):  
Manuela Cipolletti ◽  
Sara Pescatori ◽  
Filippo Acconcia
Keyword(s):  
Cell Line ◽  
Transcriptional Activity ◽  
Estrogen Receptor Α ◽  
Living Cells ◽  
Patient Treatment ◽  
Estrogen Responsive Element ◽  
Specific Proteins ◽  
Responsive Element ◽  
Mcf 7

Metastatic estrogen receptor α (ERα)-expressing breast cancer (BC) occurs after prolonged patient treatment with endocrine therapy (ET) (e.g., aromatase inhibitors—AI; 4OH-tamoxifen—4OH-Tam). Often these metastatic BCs express a mutated ERα variant (e.g., Y537S), which is transcriptionally hyperactive, sustains uncontrolled proliferation, and renders tumor cells insensitive to ET drugs. Therefore, new molecules blocking hyperactive Y537S ERα mutation transcriptional activity are requested. Here we generated an MCF-7 cell line expressing the Y537S ERα mutation stably expressing an estrogen-responsive element (ERE) promoter, which activity can be monitored in living cells. Characterization of this cell line shows both hyperactive basal transcriptional activity with respect to normal MCF-7 cells, which stably express the same ERE-based promoter and a decreased effect of selective ER downregulators (SERDs) in reducing Y537S ERα mutant transcriptional activity with respect to wild type ERα transcriptional activity. Kinetic profiles of Y537S ERα mutant-based transcription produced by both drugs inducing receptor degradation and siRNA-mediated depletion of specific proteins (e.g., FOXA1 and caveolin1) reveals biphasic dynamics of the inhibition of the receptor-regulated transcriptional effects. Overall, we report a new model where to study the behavior of the Y537S ERα mutant that can be used for the identification of new targets and pathways regulating the Y537S ERα transcriptional activity.

scholarly journals Gas Sensors Based on Mechanically Exfoliated MoS2 Nanosheets for Room-Temperature NO2 Detection

Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 2123 ◽  
Author(s):  
Wenli Li ◽  
Yong Zhang ◽  
Xia Long ◽  
Juexian Cao ◽  
Xin Xin ◽  
...  
Keyword(s):  
Gas Sensors ◽  
High Performance ◽  
Density Functional ◽  
Room Temperature ◽  
Mos2 Nanosheets ◽  
Mechanical Exfoliation ◽  
High Responsivity ◽  
Recovery Behavior ◽  
No2 Gas Sensors ◽  
No2 Detection

The unique properties of MoS2 nanosheets make them a promising candidate for high-performance room temperature gas detection. Herein, few-layer MoS2 nanosheets (FLMN) prepared via mechanical exfoliation are coated on a substrate with interdigital electrodes for room-temperature NO2 detection. Interestingly, compared with other NO2 gas sensors based on MoS2, FLMN gas sensors exhibit high responsivity for room-temperature NO2 detection, and NO2 is easily desorbed from the sensor surface with an ultrafast recovery behavior, with recovery times around 2 s. The high responsivity is related to the fact that the adsorbed NO2 can affect the electron states within the entire material, which is attributed to the very small thickness of the MoS2 nanosheets. First-principles calculations were carried out based on the density functional theory (DFT) to verify that the ultrafast recovery behavior arises from the weak van der Waals binding between NO2 and the MoS2 surface. Our work suggests that FLMN prepared via mechanical exfoliation have a great potential for fabricating high-performance NO2 gas sensors.

scholarly journals Twofold Porosity and Surface Functionalization Effect on Pt–Porous GaN for High-Performance H2-Gas Sensors at Room Temperature

ACS Omega ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 1678-1684 ◽  
Author(s):  
Muhammad Shafa ◽  
Davide Priante ◽  
Rami T. ElAfandy ◽  
Mohamed Nejib Hedhili ◽  
Saleh T. Mahmoud ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Gas Sensors ◽  
High Performance ◽  
Room Temperature

3D-multilayer MoS2 nanosheets vertically grown on highly mesoporous cubic In2O3 for high-performance gas sensing at room temperature

2019 ◽  
Vol 466 ◽  
pp. 1-11 ◽  
Author(s):  
Muhammad Ikram ◽  
Yang Liu ◽  
He Lv ◽  
Lujia Liu ◽  
Afrasiab Ur Rehman ◽  
...  
Keyword(s):  
High Performance ◽  
Room Temperature ◽  
Gas Sensing ◽  
Mos2 Nanosheets

Surface functionalization-induced photoresponse characteristics of monolayer MoS2 for fast flexible photodetectors

Nanoscale ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 4726-4734 ◽  
Author(s):  
Sangyeon Pak ◽  
A-Rang Jang ◽  
Juwon Lee ◽  
John Hong ◽  
Paul Giraud ◽  
...  
Keyword(s):  
Surface Functionalization ◽  
Monolayer Mos2

Effect of a surface-functionalization on the photoresponse of a MoS2 photodetector was studied.

scholarly journals Vanadium doped few-layer ultrathin MoS2 nanosheets on reduced graphene oxide for high-performance hydrogen evolution reaction

RSC Advances ◽  
2019 ◽  
Vol 9 (39) ◽  
pp. 22232-22239 ◽  
Author(s):  
Ashwani Kumar Singh ◽  
Jagdees Prasad ◽  
Uday Pratap Azad ◽  
Ashish Kumar Singh ◽  
Rajiv Prakash ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Hydrogen Evolution ◽  
Hydrogen Evolution Reaction ◽  
Solvothermal Synthesis ◽  
High Performance ◽  
Room Temperature ◽  
Mos2 Nanosheets ◽  
Reduced Graphene ◽  
Ultrathin Mos2 Nanosheets

In this paper, we demonstrate a facile solvothermal synthesis of a vanadium(v) doped MoS2-rGO nanocomposites for highly efficient electrochemical hydrogen evolution reaction (HER) at room temperature.

Mechanically exfoliated MoS2 nanosheets decorated with SnS2 nanoparticles for high-stability gas sensors at room temperature

Rare Metals ◽  
2020 ◽  
Author(s):  
Jia-Bei Liu ◽  
Jin-Yong Hu ◽  
Can Liu ◽  
Yu-Ming Tan ◽  
Xiang Peng ◽  
...  
Keyword(s):  
Gas Sensors ◽  
High Stability ◽  
Room Temperature ◽  
Mos2 Nanosheets

scholarly journals Room-Temperature Electron–Hole Liquid in Monolayer MoS2

ACS Nano ◽  
2019 ◽  
Vol 13 (9) ◽  
pp. 10351-10358 ◽  
Author(s):  
Yiling Yu ◽  
Alexander W. Bataller ◽  
Robert Younts ◽  
Yifei Yu ◽  
Guoqing Li ◽  
...  
Keyword(s):  
Room Temperature ◽  
Monolayer Mos2 ◽  
Electron Hole ◽  
Temperature Electron
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