Heterodimers made of metal–organic frameworks and upconversion nanoparticles for bioimaging and pH-responsive dual-drug delivery

2020 ◽  
Vol 8 (6) ◽  
pp. 1316-1325 ◽  
Author(s):  
Danping Ling ◽  
Haihong Li ◽  
Wensong Xi ◽  
Zhuo Wang ◽  
Artur Bednarkiewicz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
Upconversion Nanoparticles ◽  
Ph Responsive ◽  
Metal Organic ◽  
Ingenious Method ◽  
Dual Drug

An ingenious method was developed to grow metal–organic frameworks on the surface of UCNPs, resulting in the UCMOFs@D@5 nanosystem for bioimaging and pH-responsive dual-drug delivery.

Magnetic nanoscale metal–organic frameworks for magnetically aided drug delivery and photodynamic therapy

2017 ◽  
Vol 41 (20) ◽  
pp. 11860-11866 ◽  
Author(s):  
Shalini Sharma ◽  
Komal Sethi ◽  
Indrajit Roy
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Metal Organic Frameworks ◽  
Metal Organic ◽  
Dual Drug

Dual drug doping of magnetic nanoscale metal–organic frameworks facilitates magnetically directed chemotherapy and light activated therapy.

scholarly journals Redox-Responsive Tumor Targeted Dual-Drug Loaded Biocompatible Metal-Organic Frameworks for Enhancing Anticancer Cytotoxicity

2020 ◽  
Author(s):  
Chang Liu ◽  
Xiaoyu Xu ◽  
Junnian Zhou ◽  
Jiaqi Yan ◽  
Dongqing Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Cells ◽  
Metal Organic Frameworks ◽  
Drug Carriers ◽  
Laser Scanning Microscopy ◽  
Dichloroacetic Acid ◽  
Redox Responsive ◽  
Metal Organic ◽  
Dual Drug

Abstract Metal-organic frameworks (MOFs) have proven to be a promising class of drug carriers due to their high porosity, crystalline properties with defined structure information, and their potential for further functionalization. However, to date, no extensive research has been conducted on MOF-based drug carriers with stimuli-responsive, dual-drug delivery, and tumor targeting functions. Here, we demonstrate the strategy of constructing a redox responsive and tumor-targeted MOF, as dual-drug carrier, by anchoring functional disulfide anhydride and folic acid (FA) molecules to the organic links of MOFs, respectively. The MOF composites show the controlled release of loaded 5-fluorouracil (5-FU) entrapped within UiO-66-NH2 nanostructures modified by dichloroacetic acid (DCA). Moreover, the MOF building block DCA acts as a synergistical drug to 5-FU in cancer cells inhibition. Through disulfide bonds, the gated MOF has redox-responsive drugs release. The confocal laser scanning microscopy further proved that conjugation of folic acid to the MOF surface can significantly enhance the targeting ability to cancer cells and the cancer cell uptake of FA-MOFs. The synthesis of redox-responsive dual-drug delivery MOF hybrids paves the way to assemble of other MOF hybrids that respond to other triggering factors such as light, temperature, pH, or biomarkers. The properties and functions of such materials are expected to influence the development of sensors, new catalysts, photonic devices, and drug delivery carriers.

Controlled synthesis of up-conversion luminescent Gd/Tm-MOFs for pH-responsive drug delivery and UCL/MRI dual-modal imaging

2018 ◽  
Vol 47 (32) ◽  
pp. 11253-11263 ◽  
Author(s):  
Yana Liu ◽  
Cheng Zhang ◽  
Chen Xu ◽  
Caixue Lin ◽  
Keke Sun ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrothermal Method ◽  
Metal Organic Frameworks ◽  
Controlled Synthesis ◽  
Ph Responsive ◽  
Metal Organic ◽  
One Step

Using a facile one-step hydrothermal method, a series of metal–organic frameworks containing Gd/Tm (Gd/Tm-MOFs) were prepared successfully.

One-pot synthesis of folic acid encapsulated upconversion nanoscale metal organic frameworks for targeting, imaging and pH responsive drug release

2016 ◽  
Vol 45 (45) ◽  
pp. 18120-18132 ◽  
Author(s):  
Angshuman Ray Chowdhuri ◽  
Dipranjan Laha ◽  
Srimanta Pal ◽  
Parimal Karmakar ◽  
Sumanta Kumar Sahu
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Drug Release ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Ph Responsive ◽  
One Pot ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
One Step

A folic acid conjugated upconversion nanoscale metal organic framework is developed as a smart material in one step for targeted anticancer drug delivery.

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

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