A mitochondria-targeted fluorescent probe based on coumarin–pyridine derivatives for hypochlorite imaging in living cells and zebrafish

2019 ◽  
Vol 7 (46) ◽  
pp. 7332-7337 ◽  
Author(s):  
Xiuli Zhong ◽  
Qing Yang ◽  
Yingshuang Chen ◽  
Yuliang Jiang ◽  
Bingxiang Wang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
A549 Cells ◽  
High Sensitivity ◽  
Living Cells ◽  
Pyridine Derivative ◽  
Pyridine Derivatives ◽  
Channel Detection ◽  
Dual Channel ◽  
Stokes Shifts

Herein, a novel coumarin–pyridine derivative (CPD) was prepared and exhibited a rapid response, large Stokes shifts, dual channel detection, high selectivity and high sensitivity toward OCl− in mitochondria of A549 cells and zebrafish.

A simple chemosensor for the dual-channel detection of cyanide in water with high selectivity and sensitivity

RSC Advances ◽  
2016 ◽  
Vol 6 (32) ◽  
pp. 27130-27135 ◽  
Author(s):  
Xiao-Bin Cheng ◽  
Hui Li ◽  
Feng Zheng ◽  
Qi Lin ◽  
Hong Yao ◽  
...  
Keyword(s):  
High Selectivity ◽  
Aqueous Media ◽  
High Sensitivity ◽  
Channel Detection ◽  
Dual Channel ◽  
Sensitivity And Selectivity

By a deprotonated mechanism, the simple chemosensorHYshowed high sensitivity and selectivity for cyanide in aqueous media.

scholarly journals A Novel Fluorescent Probe for Selective Detection of Hydrazine and Its Application in Imaging

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 130
Author(s):  
Ruo-Jun Man ◽  
Meng-Ke Wu ◽  
Bing Yang ◽  
Yu-Shun Yang
Keyword(s):  
Fluorescent Probe ◽  
Water Samples ◽  
High Selectivity ◽  
High Sensitivity ◽  
Living Cells ◽  
Environmental Toxicology ◽  
Future Research ◽  
Selective Detection ◽  
Anti Cancer ◽  
First Time

In this work, a novel fluorescent probe with first-time-selected thiazepine backbone, TZPzine-1, was developed for selective detection of hydrazine in water samples and living cells. Chosen from our recent anti-cancer agents, TZPzine-1 inferred structurally based advantages of the optical adjustability and the hydrazine-trapping approach. It also showed applicable properties including high sensitivity (LOD = 50 nM), wide linear range (0–15 equiv.), high selectivity (especially from competing species), rapid response (within 20 min), and practical steadiness in various pH (6.0–11.0) and temperature (15–50 °C) conditions. To satisfy the interdisciplinary requirements in environmental toxicology, TZPzine-1 was successfully applied in water samples and living cells. We hope that the information in this work, as well as the concept of monitoring the nitrogen cycle, may be referable for future research on systematic management.

scholarly journals A Novel Coumarin-Based Fluorescent Probe With Aggregation Induced Emission for Detecting Cn− and Its Applications in Bioimaging

2021 ◽  
Author(s):  
Sha Deng ◽  
Qiao Lei ◽  
Junzhe Cai ◽  
Yuliang Jiang ◽  
Jian Shen
Keyword(s):  
Optical Properties ◽  
Excited State ◽  
High Selectivity ◽  
High Sensitivity ◽  
Intramolecular Proton Transfer ◽  
Living Cells ◽  
Aggregation Induced Emission ◽  
Channel Response ◽  
Dual Channel ◽  
Low Toxicity

Abstract Although cyanogen ion (CN-) plays important role in industry which also bring acute environmental pollution. More serious, trace CN- enters the human body can cause serious consequences and even death. Therefore, it is of great significance to detect trace CN- with high sensitivity. Herein, a novel aggregation-induced emission (AIE) probe C-BH was synthesized based on coumarin matrix. Probe C-BH showed high selectivity and sensitivity toward CN- by dual channel response due to the excited state intramolecular proton transfer (ESIPT). The low detection limit was calculated to be 0.05 µM. Moreover, probe C-BH was successfully used for imaging CN- in living cells and zebrafish due to its low toxicity and excellent optical properties.

Colorimetric and Fluorescent Probe for Hypochlorite with High Selectivity

2013 ◽  
Vol 295-298 ◽  
pp. 475-478 ◽  
Author(s):  
Zhi Xiang Han ◽  
Ming Hui Du ◽  
Guo Xi Liang ◽  
Xiang Yang Wu
Keyword(s):  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Rhodamine B ◽  
High Selectivity ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Turn On

Rhodamine B thiohydrazide (RBS) was firstly employed as turn-on fluorescent probe for hypochlorite in aqueous solution and living cells. It exhibits a stable response to hypochlorite from 1.0×10-6to 1.0×10-5M with a detection limit of 3.3×10-7M. The response of this probe to hypochlorite is fast and highly selective compared with other reactive oxygen species (such as.OH,1O2, H2O2) and other common anions (such as X-, ClO2-, ClO4-, NO3-, NO2-, OH-, Ac-, CO32-, SO42-).

A ratiometric fluorescence sensor for HOCl based on a FRET platform and application in living cells

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17059-17063 ◽  
Author(s):  
Yan-Ru Zhang ◽  
Zhi-Min Zhao ◽  
Le Su ◽  
Jun-Ying Miao ◽  
Bao-Xiang Zhao
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Fast Response ◽  
Living Cells ◽  
Fluorescence Sensor ◽  
Ratiometric Fluorescence ◽  
Ratiometric Fluorescent Probe

A ratiometric fluorescent probe CRSH based on a FRET platform for detecting HOCl. CRSH showed high selectivity, excellent sensitivity and a fast response toward HOCl.

A new ratiometric fluorescent probe for detecting endogenous HClO in living cells

2018 ◽  
Vol 42 (4) ◽  
pp. 2989-2993 ◽  
Author(s):  
Li-Jie Zhang ◽  
Jun-Ya Ning ◽  
Jun-Ying Miao ◽  
Jin-Ting Liu ◽  
Bao-Xiang Zhao
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Living Cells ◽  
Ratiometric Fluorescent Probe

A new benzimidazole-hemicyanine-based ratiometric fluorescent probe (ZBM-H) was developed, which showed high selectivity and sensitivity for detecting HClO.

scholarly journals A highly selective fluorescent probe for the sensing of Cu2+ based on the hydrolysis of a quinoline-2-carboxylate and its application in cell imaging

2020 ◽  
pp. 174751982097392
Author(s):  
Qihua You ◽  
Yihua Zhuo ◽  
Yadong Feng ◽  
Yujuan Xiao ◽  
Yanyu Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Cell Imaging ◽  
High Selectivity ◽  
Living Cells ◽  
World Health ◽  
Strong Fluorescence ◽  
The World ◽  
Phenolic Group ◽  
Health Organization ◽  
Hydrolysis Of

A highly selective OFF–ON fluorescent probe is developed for the sensing of Cu2+ based on the hydrolysis of a quinoline-2-carboxylate moiety. The probe is weakly fluorescent due to esterification of the phenolic group. Upon treatment with 1 equiv. of Cu2+, the probe exhibits strong fluorescence at 570 nm. The probe also exhibits high selectivity for Cu2+ over other cations with a low detection limit of 0.2 μM, which is sensitive enough to meet the standard of the World Health Organization for Cu2+ in drinking water (30 μM). Moreover, the probe shows a very low cell cytotoxicity, and imaging experiments demonstrate that the probe can be used for the sensing of Cu2+ in living cells.

A fast response and high sensitivity thiol fluorescent probe in living cells

2016 ◽  
Vol 232 ◽  
pp. 619-624 ◽  
Author(s):  
Tao Liu ◽  
Fangjun Huo ◽  
Jianfang Li ◽  
Jianbin Chao ◽  
Yongbin Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
High Sensitivity ◽  
Fast Response ◽  
Living Cells

Rhodamine-based “turn-on” fluorescent probe with high selectivity for Fe2+ imaging in living cells

2013 ◽  
Vol 439 (4) ◽  
pp. 459-463 ◽  
Author(s):  
Gui-Ge Hou ◽  
Chun-Hua Wang ◽  
Ju-Feng Sun ◽  
Mei-Zi Yang ◽  
Dong Lin ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
High Selectivity ◽  
Living Cells ◽  
Turn On
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