Silver-coated zero-valent iron nanoparticles enhance cancer therapy in mice through lysosome-dependent dual programed cell death pathways: triggering simultaneous apoptosis and autophagy only in cancerous cells

2020 ◽  
Vol 8 (18) ◽  
pp. 4122-4131 ◽  
Author(s):  
Li-Xing Yang ◽  
Ya-Na Wu ◽  
Pei-Wen Wang ◽  
Kuang-Jing Huang ◽  
Wu-Chou Su ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Therapy ◽  
Iron Nanoparticles ◽  
Zero Valent Iron ◽  
Anticancer Efficacy ◽  
Cell Death Pathways ◽  
Zero Valent Iron Nanoparticles ◽  
Programed Cell Death ◽  
Cancerous Cells

A schematic illustration of the possible mechanisms governing the selective anticancer efficacy of ZVI NPs.

scholarly journals From Microenvironment Remediation to Novel Anti-Cancer Strategy: The Emergence of Zero Valent Iron Nanoparticles

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 99
Author(s):  
Ya-Na Wu ◽  
Li-Xing Yang ◽  
Pei-Wen Wang ◽  
Filip Braet ◽  
Dar-Bin Shieh
Keyword(s):  
Iron Nanoparticles ◽  
Oxidative Status ◽  
Zero Valent Iron ◽  
Related Gene ◽  
Anti Cancer ◽  
Underlying Mechanisms ◽  
Zero Valent Iron Nanoparticles ◽  
Cancerous Cells

Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in vivo. The anti-cancer activity of ZVI-based nanoparticles was anti-proportional to the oxidative status of the materials, which indicates that the elemental iron is crucial for the observed cancer selectivity. In this thematic article, distinctive endogenous anti-cancer mechanisms of ZVI-related nanomaterials at the cellular and molecular levels are reviewed, including the related gene modulating profile in vitro and in vivo. From a material science perspective, the underlying mechanisms are also analyzed. In summary, ZVI-based nanomaterials demonstrated prominent potential in precision medicine to modulate both programmed cell death of cancer cells, as well as the tumor microenvironment. We believe that this will inspire advanced anti-cancer therapy in the future.

Dopamine‐Modified Zero‐Valent Iron Nanoparticles for Dual‐Modality Photothermal and Photodynamic Breast Cancer Therapy

ChemMedChem ◽  
2020 ◽  
Vol 15 (17) ◽  
pp. 1645-1651
Author(s):  
Hsin Her Yu ◽  
Chia‐Hua Lin ◽  
Yi‐Chun Chen ◽  
Hung‐Hsiang Chen ◽  
Yu‐Jing Lin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Therapy ◽  
Iron Nanoparticles ◽  
Zero Valent Iron ◽  
Breast Cancer Therapy ◽  
Dual Modality ◽  
Zero Valent Iron Nanoparticles

scholarly journals Zero-Valent Iron Nanoparticles for Soil and Groundwater Remediation

2020 ◽  
Vol 17 (16) ◽  
pp. 5817
Author(s):  
Alazne Galdames ◽  
Leire Ruiz-Rubio ◽  
Maider Orueta ◽  
Miguel Sánchez-Arzalluz ◽  
José Luis Vilas-Vilela
Keyword(s):  
Contaminated Soils ◽  
Groundwater Remediation ◽  
Iron Nanoparticles ◽  
Environmental Issues ◽  
High Specific Surface Area ◽  
Zero Valent Iron ◽  
Pilot Studies ◽  
High Effectiveness ◽  
Nanosized Materials ◽  
Zero Valent Iron Nanoparticles

Zero-valent iron has been reported as a successful remediation agent for environmental issues, being extensively used in soil and groundwater remediation. The use of zero-valent nanoparticles have been arisen as a highly effective method due to the high specific surface area of zero-valent nanoparticles. Then, the development of nanosized materials in general, and the improvement of the properties of the nano-iron in particular, has facilitated their application in remediation technologies. As the result, highly efficient and versatile nanomaterials have been obtained. Among the possible nanoparticle systems, the reactivity and availability of zero-valent iron nanoparticles (NZVI) have achieved very interesting and promising results make them particularly attractive for the remediation of subsurface contaminants. In fact, a large number of laboratory and pilot studies have reported the high effectiveness of these NZVI-based technologies for the remediation of groundwater and contaminated soils. Although the results are often based on a limited contaminant target, there is a large gap between the amount of contaminants tested with NZVI at the laboratory level and those remediated at the pilot and field level. In this review, the main zero-valent iron nanoparticles and their remediation capacity are summarized, in addition to the pilot and land scale studies reported until date for each kind of nanomaterials.

Anodic coulometry of zero-valent iron nanoparticles

2021 ◽  
Vol 896 ◽  
pp. 115331
Author(s):  
Annelis O. Sánchez-Álvarez ◽  
Jeffrey E. Dick ◽  
Eduardo Larios ◽  
Carlos R. Cabrera
Keyword(s):  
Iron Nanoparticles ◽  
Zero Valent Iron ◽  
Zero Valent Iron Nanoparticles
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