Smart textiles in wound care: functionalization of cotton/PET blends with antimicrobial nanocapsules

2019 ◽  
Vol 7 (42) ◽  
pp. 6592-6603 ◽  
Author(s):  
Felice Quartinello ◽  
Claudia Tallian ◽  
Julia Auer ◽  
Herta Schön ◽  
Robert Vielnascher ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Silk Fibroin ◽  
Wound Care ◽  
Wound Dressings ◽  
Ph Responsive ◽  
Smart Textiles

New antimicrobial pH-responsive wound dressings consisting of immobilized human serum albumin/silk fibroin nanocapsules were developed.

Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules

2018 ◽  
Vol 133 ◽  
pp. 176-187 ◽  
Author(s):  
Claudia Tallian ◽  
Alexandra Herrero-Rollett ◽  
Karina Stadler ◽  
Robert Vielnascher ◽  
Karin Wieland ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Drug Release ◽  
Serum Albumin ◽  
Human Serum ◽  
Silk Fibroin ◽  
Ph Responsive ◽  
Self Assembling ◽  
Structural Insights

pH-responsive Pt-based nanoradiosensitizer for enhanced radiotherapy via oxidative stress amplification

Nanoscale ◽  
2021 ◽  
Author(s):  
Licheng Yu ◽  
Xiaolei Zhang ◽  
Xiaomin Li ◽  
Zhenjie Zhang ◽  
Xiaoyan Niu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Chloroplatinic Acid ◽  
Ph Responsive ◽  
Simple Method ◽  
Stress Amplification

Tumor radioresistance is a major issue in radiotherapy. To address it, a pH-responsive nanoradiosensitizer was synthesized employing a simple method. Initially, chloroplatinic acid was reduced by human serum albumin (HSA)...

Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

2020 ◽  
Vol 8 (17) ◽  
pp. 3939-3948 ◽  
Author(s):  
Boya Zhang ◽  
Shiyu Wan ◽  
Xinyu Peng ◽  
Mingying Zhao ◽  
Sai Li ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Tumor Ph ◽  
Tumor Retention

A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.

Magnetic silk fibroin e-gel scaffolds for bone tissue engineering applications

2017 ◽  
Vol 32 (6) ◽  
pp. 596-614 ◽  
Author(s):  
Zeynep Karahaliloğlu ◽  
Eda Yalçın ◽  
Murat Demirbilek ◽  
Emir Baki Denkbaş
Keyword(s):  
Alkaline Phosphatase ◽  
Growth Factor ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Fibroblast Growth Factor ◽  
Silk Fibroin ◽  
Basic Fibroblast Growth Factor ◽  
Tissue Regeneration ◽  
Fibroblast Growth

Recently, the incorporation of magnetic nanoparticles into standard scaffolds has emerged as a promising approach for tissue engineering applications. This strategy can promote not only tissue regeneration but also reloading of scaffolds through an external supervising center that adsorbs growth factors, preserving their stability and biological activity. In this study, novel magnetic silk fibroin e-gel scaffolds were prepared by the electrogelation process of concentrated Bombyx mori silk fibroin (8 wt%) aqueous solution. In addition, basic fibroblast growth factor was conjugated physically to human serum albumin = Fe3O4 nanoparticles (71.52 ± 2.3 nm in size) with 97.5% binding yield. Scanning electron microscopy images of the prepared human serum albumin = Fe3O4-basic fibroblast growth factor-loaded silk fibroin e-gel scaffolds showed a three-dimensional porous morphology. In terms of water uptake, basic fibroblast growth factor-conjugated scaffolds had the highest water absorbability among all groups. In vitro cell culture studies showed that both the human serum albumin coating of Fe3O4 nanoparticle surface and basic fibroblast growth factor conjugation had an inductive effect on cell viability. One of the most used markers of bone formation and osteoblast differentiation is alkaline phosphatase activity; human serum albumin = Fe3O4-basic fibroblast growth factor-loaded silk fibroin e-gels showed significantly enhanced alkaline phosphatase activity (p < 0.05). SaOS-2 cells cultured on human serum albumin = Fe3O4-basic fibroblast growth factor-loaded silk fibroin e-gels deposited more calcium compared with those cultured on bare silk fibroin e-gels. These results indicated that the proposed e-gel scaffolds are valuable candidates for magnetic guiding in bone tissue regeneration, and they will present new perspectives for magnetic field application in regenerative medicine.

II. Lokalisation der Placenta mit 113Inm- Human-Serum-Albumin

1969 ◽  
Vol 08 (01) ◽  
pp. 15-21 ◽  
Author(s):  
K. E. Scheer ◽  
J. Heep ◽  
W. Maier-Borst ◽  
W. J. Lorenz ◽  
H. Sinn ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Vena Cava ◽  
Placenta Praevia ◽  
Wird Eine

ZusammenfassungNach tierexperimentellen Voruntersuchungen wurde die Placentographie mit trägerfreiem 113Inm -HSA als klinische Methode eingeführt. Vor Amniocentesen und bei Verdacht auf Placenta praevia werden Placentographien geschrieben. Den Schwangeren wird eine Aktivität von 500 μCi in die Cubitalvene injiziert. Die der Aktivität entsprechende Indiummenge ist kleiner als 0,1 ng. Die fetale Strahlenbelastung liegt unter lOmrad. Bei Anwendung von 113Inm-HSA entfällt eine Blockade der mütterlichen und fetalen Schilddrüsen. Die genaue Abgrenzung einer Placenta praevia wird nicht durch eine Blasenaktivität beeinträchtigt.Es wurden bisher 19 Placentalokalisationen durchgeführt. In allen Fällen konnte der Placentasitz eindeutig festgestellt werden. Bedingt durch die lange Liegezeit beim Aufnehmen eines Szintigramms kam es in zwei Fällen zu einem Vena-Cava-Kompressions-Syndrom. Zur Verhinderung dieser klinischen Zwischenfälle werden inzwischen Placentographien mit der Anger-Kamera aufgenommen. Mit Hilfe des divergierenden Kollimators konnte der gesamte Abdominalbereich erfaßt werden. Die Aufnahmezeit konnte auf 7 — 10 Minuten verkürzt werden. Die intravenöse injizierte Aktivität betrug bei dieser Methode ebenfalls 500 μCi. Der diagnostische Aussagewert der Kamerabilder ist szintigraphischen Aufnahmen gleichwertig.

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