Strategy of differentiation therapy: effect of dual-frequency ultrasound on the induction of liver cancer stem-like cells on a HA-based multilayer film system

2019 ◽  
Vol 7 (35) ◽  
pp. 5401-5411 ◽  
Author(s):  
I-Chi Lee ◽  
Siaka Fadera ◽  
Hao-Li Liu
Keyword(s):  
Drug Resistance ◽  
Liver Cancer ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Film System ◽  
Dual Frequency ◽  
Differentiation Therapy ◽  
System P ◽  
Therapy Effect ◽  
Frequency Ultrasound

HA-based multilayer films were used to select CSCs, and LIUS induces CSC differentiation and reduces drug resistance and invasion ability.

scholarly journals Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1715
Author(s):  
Macus Hao-Ran Bao ◽  
Carmen Chak-Lui Wong
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Resistance ◽  
Liver Cancer ◽  
Effective Treatment ◽  
Molecular Mechanisms ◽  
Hypoxia Inducible Factor ◽  
Metabolic Reprogramming ◽  
Combination Therapies ◽  
Low Oxygen ◽  
Treatment Regimens

Hypoxia, low oxygen (O2) level, is a hallmark of solid cancers, especially hepatocellular carcinoma (HCC), one of the most common and fatal cancers worldwide. Hypoxia contributes to drug resistance in cancer through various molecular mechanisms. In this review, we particularly focus on the roles of hypoxia-inducible factor (HIF)-mediated metabolic reprogramming in drug resistance in HCC. Combination therapies targeting hypoxia-induced metabolic enzymes to overcome drug resistance will also be summarized. Acquisition of drug resistance is the major cause of unsatisfactory clinical outcomes of existing HCC treatments. Extra efforts to identify novel mechanisms to combat refractory hypoxic HCC are warranted for the development of more effective treatment regimens for HCC patients.

Treatment of Murine Tumors Using Dual-Frequency Ultrasound in an Experimental in Vivo Model

2009 ◽  
Vol 35 (5) ◽  
pp. 756-763 ◽  
Author(s):  
Amir H. Barati ◽  
Manijhe Mokhtari-Dizaji ◽  
Hossein Mozdarani ◽  
S. Zahra Bathaie ◽  
Zuhair M. Hassan
Keyword(s):  
In Vivo Model ◽  
Dual Frequency ◽  
Murine Tumors ◽  
Frequency Ultrasound

scholarly journals The Efficacy and Safety of Dual-Frequency Ultrasound for Improving Skin Hydration and Erythema in Patients with Rosacea and Acne

2021 ◽  
Vol 10 (4) ◽  
pp. 834
Author(s):  
Young Jae Kim ◽  
Ik Jun Moon ◽  
Hae Woong Lee ◽  
Chong Hyun Won ◽  
Sung Eun Chang ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Skin Barrier ◽  
Skin Hydration ◽  
Efficacy And Safety ◽  
Dual Frequency ◽  
Barrier Dysfunction ◽  
Inflammatory Skin Diseases ◽  
Facial Erythema ◽  
Frequency Ultrasound

Inflammatory skin diseases, such as rosacea and acne, are major causes of facial erythema and accompanying skin barrier dysfunction. Several methods to restore the impaired skin barrier and improve facial erythema, such as medication, radiofrequency, laser, and ultrasound therapy were attempted. This study evaluated the efficacy and safety of dual-frequency ultrasound with impulse mode, for improving skin hydration and erythema in Asian subjects with rosacea and acne. Twenty-six subjects with facial erythema received an ultrasound treatment once per week, for 4 weeks, over both cheeks. The erythema index and transepidermal water loss (TEWL) were measured at each visit. Clinicians assessed the erythema improvement and patients evaluated their satisfaction level. The average decrease in TEWL and erythema index at 6 weeks was 5.37 ± 13.22 g·h−1·m−2 (p = 0.020) and 39.73 ± 44.21 (p = 0.010), respectively. The clinician’s erythema assessment and the subject satisfaction questionnaire score significantly improved at final follow-up (p < 0.001; p = 0.003, respectively). No serious adverse effects were observed during the treatment and follow-up periods. The dual-frequency ultrasound with impulse mode appears to be effective and safe for improving skin hydration and erythema in patients with rosacea and acne.

scholarly journals Controlled delivery of a protein tyrosine phosphatase inhibitor, SHP099, using cyclodextrin-mediated host–guest interactions in polyelectrolyte multilayer films for cancer therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (34) ◽  
pp. 20073-20082 ◽  
Author(s):  
Soobin Wang ◽  
Alessia Battigelli ◽  
Dahlia Alkekhia ◽  
Alexis Fairman ◽  
Valentin Antoci ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Anticancer Drug ◽  
Protein Tyrosine Phosphatase ◽  
Multilayer Film ◽  
Tyrosine Phosphatase ◽  
Multilayer Films ◽  
Controlled Delivery ◽  
Polyelectrolyte Multilayer ◽  
Supramolecular Complexation ◽  
Protein Tyrosine Phosphatase Inhibitor

Controlled delivery of a potent anticancer drug, SHP099, after supramolecular complexation into a versatile multilayer film.

scholarly journals Recycling of multilayer plastic packaging materials by solvent-targeted recovery and precipitation

2020 ◽  
Vol 6 (47) ◽  
pp. eaba7599
Author(s):  
Theodore W. Walker ◽  
Nathan Frelka ◽  
Zhizhang Shen ◽  
Alex K. Chew ◽  
Jesse Banick ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Multilayer Film ◽  
Multilayer Films ◽  
Packaging Materials ◽  
Constant Composition ◽  
Waste Streams ◽  
Ethylene Vinyl Alcohol ◽  
Plastic Packaging ◽  
Material Efficiency ◽  
Polymer Solubility

Many plastic packaging materials manufactured today are composites made of distinct polymer layers (i.e., multilayer films). Billions of pounds of these multilayer films are produced annually, but manufacturing inefficiencies result in large, corresponding postindustrial waste streams. Although relatively clean (as opposed to municipal wastes) and of near-constant composition, no commercially practiced technologies exist to fully deconstruct postindustrial multilayer film wastes into pure, recyclable polymers. Here, we demonstrate a unique strategy we call solvent-targeted recovery and precipitation (STRAP) to deconstruct multilayer films into their constituent resins using a series of solvent washes that are guided by thermodynamic calculations of polymer solubility. We show that the STRAP process is able to separate three representative polymers (polyethylene, ethylene vinyl alcohol, and polyethylene terephthalate) from a commercially available multilayer film with nearly 100% material efficiency, affording recyclable resins that are cost-competitive with the corresponding virgin materials.

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