Nanoparticle-based diagnostic and therapeutic systems for brain tumors

2019 ◽  
Vol 7 (31) ◽  
pp. 4734-4750 ◽  
Author(s):  
Xiaoli Wu ◽  
Han Yang ◽  
Weitao Yang ◽  
Xingmeng Chen ◽  
Junxiao Gao ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
High Efficiency ◽  
Therapeutic Agents ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Theranostic Nanoparticles ◽  
Brain Tumor Diagnosis

Many theranostic nanoparticles have been tailored for high-efficiency diagnostic or therapeutic agents or applied as carriers and might provide new possibilities for brain tumor diagnosis and treatment.

Parental Fears Following Their Child's Brain Tumor Diagnosis and Treatment

2009 ◽  
Vol 26 (2) ◽  
pp. 68-74 ◽  
Author(s):  
M. Anclair ◽  
E. Hovén ◽  
B. Lannering ◽  
K.K. Boman
Keyword(s):  
Brain Tumor ◽  
Tumor Diagnosis ◽  
Diagnosis And Treatment ◽  
Brain Tumor Diagnosis ◽  
Child's Brain

scholarly journals The Many Roles of the Rock: A Qualitative Inquiry into the Roles and Responsibilities of Fathers of Children with Brain Tumors

Children ◽  
2019 ◽  
Vol 6 (10) ◽  
pp. 113 ◽  
Author(s):  
Jacob E. Robinson ◽  
David Huskey ◽  
Jonathan Schwartz ◽  
Meaghann S. Weaver
Keyword(s):  
Palliative Care ◽  
Brain Tumor ◽  
Brain Tumors ◽  
Personal Growth ◽  
Pediatric Brain Tumor ◽  
Qualitative Inquiry ◽  
Tumor Diagnosis ◽  
Support Needs ◽  
Brain Tumor Diagnosis ◽  
Pediatric Brain

A pediatric brain tumor diagnosis impacts an entire family unit, from diagnosis through curative treatment, and into survivorship or bereavement. Paternal caregiver experience has been significantly underexplored in pediatric neuro-oncology research as compared to maternal experience. This case series study explores the paternal roles, responsibilities, strengths, challenges, personal growth, and support needs of fathers of children with brain tumors receiving new palliative care consultations. In the study setting, a neuro-oncology diagnosis results in an automatic referral to the palliative care team, and thus, a convenience sampling model was employed based on consecutive palliative care consults for new childhood brain tumor diagnoses. In this study, four fathers of pediatric brain tumor patients receiving palliative care consultations responded to eight open-ended questions. Individual, voice-recorded interviews were transcribed for semantic content qualitative analysis. Analysis followed Consolidated Criteria for Reporting Qualitative Research (COREQ) guidelines. Participants completed quantitative surveys of their information preferences and support needs. Participants defined their father role as: being a team parent, an adaptable father, supporter, provider, a present father, and protector. Role conflict due to paternal responsibilities were recognized, such as the absence from the hospital to provide financial security for the family, and yet a desire to be physically present for the child. Fathers prioritized their knowledge needs about their child’s diagnosis, prognosis, and treatment above emotional needs. Fathers shared experiences of their personal growth through their child’s brain tumor diagnosis and advised on preferred support formats to include both verbal and written information. Understanding how paternal caregivers of children with cancer define their roles and goals has potential to improve the care and communication delivered to families of pediatric neuro-oncology patients.

Smear technique in the intra-operative brain tumor diagnosis: Its advantages and limitations

1999 ◽  
Vol 21 (1) ◽  
pp. 121-124 ◽  
Author(s):  
J. Slowiński ◽  
M. Harabin-Slowińska ◽  
R. Mrówka
Keyword(s):  
Brain Tumor ◽  
Tumor Diagnosis ◽  
Brain Tumor Diagnosis

scholarly journals Cancer Imaging and Brain Tumor Diagnosis

2017 ◽  
Vol 09 (01) ◽  
Author(s):  
Hamidreza Shirzadfar ◽  
Samin Riahi ◽  
Mahsa Sadat Ghaziasgar
Keyword(s):  
Brain Tumor ◽  
Cancer Imaging ◽  
Tumor Diagnosis ◽  
Brain Tumor Diagnosis

scholarly journals Pharmacodynamic Analysis of Magnetic Resonance Imaging-Monitored Focused Ultrasound-Induced Blood-Brain Barrier Opening for Drug Delivery to Brain Tumors

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Po-Chun Chu ◽  
Wen-Yen Chai ◽  
Han-Yi Hsieh ◽  
Jiun-Jie Wang ◽  
Shiaw-Pyng Wey ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Tumors ◽  
Small Molecule ◽  
Focused Ultrasound ◽  
Therapeutic Agents ◽  
Tumor Treatment ◽  
Target Region ◽  
Pharmacodynamic Analysis ◽  
The Brain ◽  
Bbb Opening

Microbubble-enhanced focused ultrasound (FUS) can enhance the delivery of therapeutic agents into the brain for brain tumor treatment. The purpose of this study was to investigate the influence of brain tumor conditions on the distribution and dynamics of small molecule leakage into targeted regions of the brain after FUS-BBB opening. A total of 34 animals were used, and the process was monitored by 7T-MRI. Evans blue (EB) dye as well as Gd-DTPA served as small molecule substitutes for evaluation of drug behavior. EB was quantified spectrophotometrically. Spin-spin (R1) relaxometry and area under curve (AUC) were measured by MRI to quantify Gd-DTPA. We found that FUS-BBB opening provided a more significant increase in permeability with small tumors. In contrast, accumulation was much higher in large tumors, independent of FUS. The AUC values of Gd-DTPA were well correlated with EB delivery, suggesting that Gd-DTPA was a good indicator of total small-molecule accumulation in the target region. The peripheral regions of large tumors exhibited similar dynamics of small-molecule leakage after FUS-BBB opening as small tumors, suggesting that FUS-BBB opening may have the most significant permeability-enhancing effect on tumor peripheral. This study provides useful information toward designing an optimized FUS-BBB opening strategy to deliver small-molecule therapeutic agents into brain tumors.

Sign in / Sign up

Export Citation Format

Share Document