cAMP-modulated biomimetic ionic nanochannels based on a smart polymer

2019 ◽  
Vol 7 (23) ◽  
pp. 3710-3715 ◽  
Author(s):  
Zhixiang Chen ◽  
Taolei Sun ◽  
Guangyan Qing
Keyword(s):  
Conformational Transition ◽  
Adenosine Monophosphate ◽  
Specific Adsorption ◽  
Polymer Chains ◽  
Smart Polymer

Dynamic gating behaviour of ionic nanochannel is precisely manipulated by cyclic 3′,5′-adenosine monophosphate (cAMP) by taking advantage of reversible conformational transition of the smart polymer chains in response to cAMP specific adsorption, which provides a new idea for developing smart nanochannels regulated by crucial signal-biomolecules.

cAMP sensitive nanochannels driven by conformational transition of a tripeptide-based smart polymer

2020 ◽  
Vol 56 (23) ◽  
pp. 3425-3428
Author(s):  
Shengyan Ji ◽  
Yuting Xiong ◽  
Wenqi Lu ◽  
Minmin Li ◽  
Xue Wang ◽  
...  
Keyword(s):  
Conformational Transition ◽  
Polymer Chains ◽  
Smart Polymer ◽  
Coil Transition ◽  
Opening And Closing

The opening and closing of nanochannels are precisely manipulated by cAMP through globule to coil transition of smart polymer chains.

scholarly journals Conformational Transitions of Polymer Chains in Solutions Characterized by Fluorescence Resonance Energy Transfer

Polymers ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1007 ◽  
Author(s):  
Linlin Qin ◽  
Linling Li ◽  
Ye Sha ◽  
Ziyu Wang ◽  
Dongshan Zhou ◽  
...  
Keyword(s):  
Energy Transfer ◽  
Fluorescence Resonance Energy Transfer ◽  
Conformational Changes ◽  
Conformational Transition ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
Polymer Chains ◽  
Donor And Acceptor ◽  
Transition Concentration ◽  
Fluorescence Resonance

The critical overlap concentration C* is an important concept in polymer solutions and is defined as the boundary between dilute and semidilute regimes. In this study, the chain conformational changes of polystyrene (PS) with both high (Mn = 200,000 Da) and low (Mn = 13,000 Da) molecular weights in cis-decalin were compared by intrachain fluorescence resonance energy transfer (FRET). The random labeling of donor and acceptor chromophores strategy was employed for long PS chains, whereas chain-end labeling was used for short PS chains. By monitoring the spectroscopic intensity ratio between acceptor and donor, the concentration dependence on chain conformation from dilute to semidilute solutions was determined. Both long and short chains exhibit a conformational transition concentration, above which the polymer chains begin to collapse with concentration significantly. Interestingly, for randomly labeled polymer long chains, such concentration is consistent with C* determined from the viscosity result, below which only slight conformational change of polymer chain takes place. However, for the chain-end labeled short chain, the conformational transition concentration takes place earlier than C*, below which no significant polymer conformation change is observed.

scholarly journals Polymers with pendant ferrocenes

2016 ◽  
Vol 45 (19) ◽  
pp. 5216-5231 ◽  
Author(s):  
Rudolf Pietschnig
Keyword(s):  
Polymer Chains ◽  
Smart Polymer ◽  
The Difference

Charges make the difference in the arrangement of smart polymer chains and networks.

Elucidating cyclic AMP signaling in subcellular domains with optogenetic tools and fluorescent biosensors

2019 ◽  
Vol 47 (6) ◽  
pp. 1733-1747 ◽  
Author(s):  
Christina Klausen ◽  
Fabian Kaiser ◽  
Birthe Stüven ◽  
Jan N. Hansen ◽  
Dagmar Wachten
Keyword(s):  
Cyclic Amp ◽  
Adenosine Monophosphate ◽  
Adenylyl Cyclases ◽  
Temporal Precision ◽  
Fluorescent Biosensors ◽  
Subcellular Domains ◽  
Spatio Temporal ◽  
Hydrolysis Of ◽  
Shed Light ◽  
Cyclic Amp Signaling

The second messenger 3′,5′-cyclic nucleoside adenosine monophosphate (cAMP) plays a key role in signal transduction across prokaryotes and eukaryotes. Cyclic AMP signaling is compartmentalized into microdomains to fulfil specific functions. To define the function of cAMP within these microdomains, signaling needs to be analyzed with spatio-temporal precision. To this end, optogenetic approaches and genetically encoded fluorescent biosensors are particularly well suited. Synthesis and hydrolysis of cAMP can be directly manipulated by photoactivated adenylyl cyclases (PACs) and light-regulated phosphodiesterases (PDEs), respectively. In addition, many biosensors have been designed to spatially and temporarily resolve cAMP dynamics in the cell. This review provides an overview about optogenetic tools and biosensors to shed light on the subcellular organization of cAMP signaling.

Shape of Confined Polymer Chains

1997 ◽  
Vol 7 (3) ◽  
pp. 433-447 ◽  
Author(s):  
C. E. Cordeiro ◽  
M. Molisana ◽  
D. Thirumalai
Keyword(s):  
Polymer Chains ◽  
Confined Polymer ◽  
Confined Polymer Chains

Dynamics of polymer chains trapped in a slit

1977 ◽  
Vol 38 (10) ◽  
pp. 1285-1291 ◽  
Author(s):  
F. Brochard
Keyword(s):  
Polymer Chains
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