A mitochondria-targeted two-photon fluorogenic probe for the dual-imaging of viscosity and H2O2 levels in Parkinson's disease models

2019 ◽  
Vol 7 (27) ◽  
pp. 4243-4251 ◽  
Author(s):  
Hao Li ◽  
Chenqi Xin ◽  
Gaobin Zhang ◽  
Xisi Han ◽  
Wenjing Qin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Disease Models ◽  
Two Photon ◽  
Fluorogenic Probe ◽  
Dual Imaging

Novel two-photon fluorogenic probe could simultaneously monitor changes in the mitochondrial viscosity and H2O2 levels using two different channels.

A novel pyrimidine based deep-red fluorogenic probe for detecting hydrogen peroxide in Parkinson's disease models

Talanta ◽  
2019 ◽  
Vol 199 ◽  
pp. 628-633 ◽  
Author(s):  
Xinghan Qiu ◽  
Chenqi Xin ◽  
Wenjing Qin ◽  
Zheng Li ◽  
Duoteng Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Hydrogen Peroxide ◽  
Parkinson's Disease ◽  
Disease Models ◽  
Fluorogenic Probe

Deep-red fluorogenic probe for rapid detection of nitric oxide in Parkinson’s disease models

2019 ◽  
Vol 283 ◽  
pp. 769-775 ◽  
Author(s):  
Mingrui Weng ◽  
Xue Yang ◽  
Yun Ni ◽  
Chenchen Xu ◽  
Hang Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rapid Detection ◽  
Disease Models ◽  
Fluorogenic Probe

scholarly journals A sensitive two-photon probe to selectively detect monoamine oxidase B activity in Parkinson’s disease models

2014 ◽  
Vol 5 (1) ◽  
Author(s):  
Lin Li ◽  
Cheng-Wu Zhang ◽  
Grace Y. J. Chen ◽  
Biwei Zhu ◽  
Chou Chai ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Monoamine Oxidase ◽  
Disease Models ◽  
Monoamine Oxidase B ◽  
Two Photon

A fluorogenic probe based on chelation–hydrolysis-enhancement mechanism for visualizing Zn2+ in Parkinson's disease models

2019 ◽  
Vol 7 (14) ◽  
pp. 2252-2260 ◽  
Author(s):  
Gaobin Zhang ◽  
Yanfei Zhao ◽  
Bo Peng ◽  
Zheng Li ◽  
Chenchen Xu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Real Time ◽  
Biological Systems ◽  
Disease Models ◽  
Enhancement Mechanism ◽  
Fluorogenic Probe ◽  
Real Time Detection ◽  
Role Of Zn

Developing efficient methods for real-time detection of Zn2+ level in biological systems is highly relevant to improve our understanding of the role of Zn2+ in the progression of Parkinson's disease (PD).

A two-photon fluorescent probe for visualizing endoplasmic reticulum peroxynitrite in Parkinson's disease models

2021 ◽  
Vol 328 ◽  
pp. 129003 ◽  
Author(s):  
Ming Yan ◽  
Haixiao Fang ◽  
Xiaoqing Wang ◽  
Jiajia Xu ◽  
Chengwu Zhang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Endoplasmic Reticulum ◽  
Fluorescent Probe ◽  
Disease Models ◽  
Two Photon

scholarly journals A novel fluorogenic probe for visualizing the hydrogen peroxide in Parkinson’s disease models

2020 ◽  
Vol 13 (03) ◽  
pp. 2050013
Author(s):  
Gaobin Zhang ◽  
Zheng Li ◽  
Fangjie Chen ◽  
Duoteng Zhang ◽  
Wenhui Ji ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Hydrogen Peroxide ◽  
Parkinson's Disease ◽  
Living Cells ◽  
Emission Peak ◽  
Disease Models ◽  
Fluorogenic Probe ◽  
Highly Sensitive ◽  
Living Organisms

Parkinson’s disease (PD) is closely related to the oxidative stress induced by excess hydrogen peroxide (H2O2) in organisms. Developing an efficient method for noninvasive and real-time H2O2 detection is beneficial to investigate the role played by H2O2 in PD. In this work, a novel fluorogenic probe (CBH) for living organisms H2O2 detection has been designed, synthesized and characterized. The emission of CBH in PBS solution is very weak. However, when H2O2 was added, the fluorescence of CBH solution was sharply increased for 12-fold, accompanied by the emission peak blue-shifted from 600 to 530 nm. Moreover, the response of CBH to H2O2 is highly sensitive and selective and is not affected by various ROS/RNS, anions, cations, and amino acids. Based on the good performance of CBH for H2O2 detection, it has been successfully applied to visualizing the H2O2 concentration in living cells, Zebrafish and [Formula: see text]. elegans PD models.

Sign in / Sign up

Export Citation Format

Share Document