Dual acid-responsive bola-type supramolecular vesicles for efficient intracellular anticancer drug delivery

2019 ◽  
Vol 7 (25) ◽  
pp. 3944-3949 ◽  
Author(s):  
Guangping Sun ◽  
Zhimei He ◽  
Min Hao ◽  
Minzan Zuo ◽  
Zuqiang Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery

Dual acid-responsive bola-type supramolecular vesicles have been successfully constructed for efficient intracellular anticancer drug delivery and controlled release.

scholarly journals pH controlled release anticancer drug delivery based on poly(A)/SiO<sub>2</sub> nanoparticles

2014 ◽  
Vol 59 (2) ◽  
pp. 181-187
Author(s):  
Zhen ZOU ◽  
KeMin WANG ◽  
SuYe CHEN ◽  
XiaoXiao HE ◽  
YuShuang WANG ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Ph Controlled

scholarly journals Dual pH/Redox-Responsive Mixed Polymeric Micelles for Anticancer Drug Delivery and Controlled Release

Pharmaceutics ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 176 ◽  
Author(s):  
Yongle Luo ◽  
Xujun Yin ◽  
Xi Yin ◽  
Anqi Chen ◽  
Lili Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Anticancer Drug ◽  
Diblock Copolymers ◽  
Polymeric Micelles ◽  
Stimuli Responsive ◽  
Anticancer Drug Delivery ◽  
Amino Esters ◽  
Redox Responsive ◽  
Poly Ethylene

Stimuli-responsive polymeric micelles (PMs) have shown great potential in drug delivery and controlled release in cancer chemotherapy. Herein, inspired by the features of the tumor microenvironment, we developed dual pH/redox-responsive mixed PMs which are self-assembled from two kinds of amphiphilic diblock copolymers (poly(ethylene glycol) methyl ether-b-poly(β-amino esters) (mPEG-b-PAE) and poly(ethylene glycol) methyl ether-grafted disulfide-poly(β-amino esters) (PAE-ss-mPEG)) for anticancer drug delivery and controlled release. The co-micellization of two copolymers is evaluated by measurement of critical micelle concentration (CMC) values at different ratios of the two copolymers. The pH/redox-responsiveness of PMs is thoroughly investigated by measurement of base dissociation constant (pKb) value, particle size, and zeta-potential in different conditions. The PMs can encapsulate doxorubicin (DOX) efficiently, with high drug-loading efficacy. The DOX was released due to the swelling and disassembly of nanoparticles triggered by low pH and high glutathione (GSH) concentrations in tumor cells. The in vitro results demonstrated that drug release rate and cumulative release are obviously dependent on pH values and reducing agents. Furthermore, the cytotoxicity test showed that the mixed PMs have negligible toxicity, whereas the DOX-loaded mixed PMs exhibit high cytotoxicity for HepG2 cells. Therefore, the results demonstrate that the dual pH/redox-responsive PMs self-assembled from PAE-based diblock copolymers could be potential anticancer drug delivery carriers with pH/redox-triggered drug release, and the fabrication of stimuli-responsive mixed PMs could be an efficient strategy for preparation of intelligent drug delivery platform for disease therapy.

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies
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